Zobrazeno 1 - 10
of 126
pro vyhledávání: '"Wufu Zhu"'
Autor:
Linxiao Wang, Xiaoling Huang, Shidi Xu, Yufeng An, Xinya Lv, Wufu Zhu, Shan Xu, Yuanbiao Tu, Shuhui Chen, Qiaoli Lv, Pengwu Zheng
Publikováno v:
BMC Chemistry, Vol 18, Iss 1, Pp 1-14 (2024)
Abstract Background Facing the significant challenge of overcoming drug resistance in cancer treatment, particularly resistance caused by mutations in epidermal growth factor receptor (EGFR), the aim of our study was to identify potent EGFR inhibitor
Externí odkaz:
https://doaj.org/article/dc1948ba5a58471095b3f8bb7ecc4a8e
Autor:
Zhiqin Lu, Yali Yi, Linxiao Wang, Yuxi Luo, Daya Luo, Le Xiong, Yun Shu, Hui Luo, Jing Li, Wufu Zhu, Zhimin Zeng, Anwen Liu
Publikováno v:
Translational Oncology, Vol 39, Iss , Pp 101834- (2024)
Background: This study compared the clinical efficacy of first-, second-, and third-generation tyrosine kinase inhibitors (TKIs) in previously untreated non-small cell lung cancer (NSCLC) patients harboring uncommon epidermal growth factor receptor (
Externí odkaz:
https://doaj.org/article/9d9ce6fbad8b48ddbab602bd7b4b158e
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/a3db8d432ad74d798b5aac16dd95b24d
Autor:
Leixuan Luo, Xin Sun, Yang Yang, Lulu Xia, Shiyu Wang, Yuxing Fu, Yuxuan Zhu, Shan Xu, Wufu Zhu
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 19, p 14821 (2023)
An imbalance in PI3K/AKT/mTOR pathway signaling in humans often leads to cancer. Therefore, the investigation of anti-cancer medications that inhibit PI3K and mTOR has emerged as a significant area of research. The aim of this study was to explore th
Externí odkaz:
https://doaj.org/article/7fe74ef4246c41449c350ed1b1839125
Autor:
Shan Xu, Xin Sun, Leixuan Luo, Yang Yang, Qiuyan Guo, Sheng Tang, Zhiyan Jiang, Yuzhen Li, Jiaqian Han, Wenhui Gan, Feiyi Yang, Xuan Zhang, Yijun Liu, Chuanchuan Sun, Jie He, Meng Liu, Daiying Zuo, Wufu Zhu, Yingliang Wu
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 155, Iss , Pp 113537- (2022)
Breast cancer has become the most commonly diagnosed cancer, surpassing lung cancer, with 2.26 million new breast cancers worldwide in 2020. Hence, there is an urgent need to develop effective molecularly targeted therapeutic drugs to treat breast ca
Externí odkaz:
https://doaj.org/article/fefec4ccb42946699ef2c27b7c718346
Autor:
Xiaobo Liu, Yuzhen Li, Qian Zhang, Qingshan Pan, Pengwu Zheng, Xinyang Dai, Zhaoshi Bai, Wufu Zhu
Publikováno v:
Frontiers in Chemistry, Vol 10 (2022)
In this study, we designed and synthesized a series of novel [1,2,4]triazolo [4,3-a]pyrazine derivatives, and evaluated them for their inhibitory activities toward c-Met/VEGFR-2 kinases and antiproliferative activities against tested three cell lines
Externí odkaz:
https://doaj.org/article/910ccfd3cff647398a4d6ac448940e3b
Autor:
Qian Zhang, Xiaobo Liu, Wenhui Gan, Jinjin Wu, Hualan Zhou, Zunhua Yang, Yiling Zhang, Min Liao, Ping Yuan, Shan Xu, Pengwu Zheng, Wufu Zhu
Publikováno v:
ACS Omega, Vol 5, Iss 27, Pp 16482-16490 (2020)
Externí odkaz:
https://doaj.org/article/d491cecffc82411f89ec6ad04e48b7f6
Publikováno v:
Biosensors, Vol 12, Iss 12, p 1070 (2022)
Diagnostic blood cell counting is of limited use in monitoring a minimal number of leukaemia cells, warranting further research to develop more sensitive and reliable techniques to identify leukaemia cells in circulation. In this work, a hemin–grap
Externí odkaz:
https://doaj.org/article/3a60c0aba8cc4515a589be1b389b26a9
Autor:
Caolin Wang, Shan Xu, Liang Peng, Bingliang Zhang, Hong Zhang, Yingying Hu, Pengwu Zheng, Wufu Zhu
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 203-217 (2019)
A series of quinazoline derivatives with benzylidene hydrazine carboxamide were designed and synthesised as EGFR inhibitors. Most compounds exhibited exceptional anti-proliferative activity against A549, HepG2, MCF-7 and H1975 cells. Furthermore, six
Externí odkaz:
https://doaj.org/article/b6667df4acdd496db8d0f8b03a20c120
Publikováno v:
Molecules, Vol 27, Iss 5, p 1587 (2022)
Tubulin inhibitors can interfere with normal cell mitosis and inhibit cell proliferation through interfering with the normal structure and function of microtubules, forming spindle filaments. Indole, as a privileged pharmacological skeleton, has been
Externí odkaz:
https://doaj.org/article/3e940da433a64e588d3a745b2109c836