Product Studies and Mechanistic Analysis of the Reaction of Methylglyoxal with Deoxyguanosine.

Autor: Shuck SC; Department of Molecular Medicine, City of Hope and Beckman Research Institute , Duarte, California 91010, United States., Wuenschell GE; Department of Molecular Medicine, City of Hope and Beckman Research Institute , Duarte, California 91010, United States., Termini JS; Department of Molecular Medicine, City of Hope and Beckman Research Institute , Duarte, California 91010, United States.

Publikováno v: Chemical research in toxicology [Chem Res Toxicol] 2018 Feb 19; Vol. 31 (2), pp. 105-115. Date of Electronic Publication: 2018 Jan 31.

Inhibition of GLO1 in Glioblastoma Multiforme Increases DNA-AGEs, Stimulates RAGE Expression, and Inhibits Brain Tumor Growth in Orthotopic Mouse Models.

Autor: Jandial R; Division of Neurosurgery, City of Hope & Beckman Research Institute, 1500 East Duarte Road, Duarte, CA 91010, USA. rjandial@coh.org., Neman J; Division of Neurosurgery, City of Hope & Beckman Research Institute, 1500 East Duarte Road, Duarte, CA 91010, USA. yebrahim@usc.edu.; Department of Neurosurgery, Keck School Medicine, University of Southern California, 1975 Zonal Ave., Los Angeles, CA 90033, USA. yebrahim@usc.edu., Lim PP; Department of Molecular Medicine, City of Hope & Beckman Research Institute, 1500 East Duarte Road, Duarte, CA 91010, USA. plim@coh.org., Tamae D; Department of Molecular Medicine, City of Hope & Beckman Research Institute, 1500 East Duarte Road, Duarte, CA 91010, USA. daniel.tamae@csun.edu.; Irell and Manella Graduate School of Biological Sciences, City of Hope & Beckman Research Institute, 1500 East Duarte Road, Duarte, CA 91010, USA. daniel.tamae@csun.edu.; Department of Chemistry and Biochemistry, California State University, Northridge, 18111 Nordhoff Street, Northridge, CA 91330, USA. daniel.tamae@csun.edu., Kowolik CM; Department of Molecular Medicine, City of Hope & Beckman Research Institute, 1500 East Duarte Road, Duarte, CA 91010, USA. ckowolik@coh.org., Wuenschell GE; Department of Molecular Medicine, City of Hope & Beckman Research Institute, 1500 East Duarte Road, Duarte, CA 91010, USA. gwuenschell@coh.org., Shuck SC; Department of Molecular Medicine, City of Hope & Beckman Research Institute, 1500 East Duarte Road, Duarte, CA 91010, USA. sshuck@coh.org., Ciminera AK; Department of Molecular Medicine, City of Hope & Beckman Research Institute, 1500 East Duarte Road, Duarte, CA 91010, USA. aciminera@coh.org.; Irell and Manella Graduate School of Biological Sciences, City of Hope & Beckman Research Institute, 1500 East Duarte Road, Duarte, CA 91010, USA. aciminera@coh.org., De Jesus LR; Department of Molecular Medicine, City of Hope & Beckman Research Institute, 1500 East Duarte Road, Duarte, CA 91010, USA. luis.dejesus@chem.tamu.edu.; Department of Chemistry, Texas A&M University, PO Box 30012, College Station, TX 77842, USA. luis.dejesus@chem.tamu.edu., Ouyang C; Center for Informatics, City of Hope & Beckman Research Institute, 1500 East Duarte Road, Duarte, CA 91010, USA. couyang@coh.org., Chen MY; Division of Neurosurgery, City of Hope & Beckman Research Institute, 1500 East Duarte Road, Duarte, CA 91010, USA. mchen@coh.org., Termini J; Department of Molecular Medicine, City of Hope & Beckman Research Institute, 1500 East Duarte Road, Duarte, CA 91010, USA. jtermini@coh.org.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2018 Jan 30; Vol. 19 (2). Date of Electronic Publication: 2018 Jan 30.

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Methylglyoxal, a highly reactive dicarbonyl compound, as a threat for blood brain barrier integrity.

Autor: Berends, Eline^1,2 (AUTHOR), van Oostenbrugge, Robert J^2,3,4 (AUTHOR), Foulquier, Sébastien^2,4,5 (AUTHOR) s.foulquier@maastrichtuniversity.nl, Schalkwijk, Casper G^1,2 (AUTHOR) c.schalkwijk@maastrichtuniversity.nl

Publikováno v: Fluids & Barriers of the CNS. 10/24/2023, Vol. 20 Issue 1, p1-15. 15p.

Glyoxalase 1 increases anxiety by reducing GABAA receptor agonist methylglyoxal.

Autor: Distler MG; Department of Pathology, University of Chicago, Chicago, Illinois 60637, USA., Plant LD, Sokoloff G, Hawk AJ, Aneas I, Wuenschell GE, Termini J, Meredith SC, Nobrega MA, Palmer AA

Publikováno v: The Journal of clinical investigation [J Clin Invest] 2012 Jun; Vol. 122 (6), pp. 2306-15. Date of Electronic Publication: 2012 May 15.