One-pot synthesis and covalent conjugation of methylene blue in mesoporous silica nanoparticles – A platform for enhanced photodynamic therapy

Autor: Kirla, Haritha, Wu, Jiansha, Hamzah, Juliana, Henry, David J.

Publikováno v: In Colloids and Surfaces B: Biointerfaces January 2025 245

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Immune-mediated ECM depletion improves tumour perfusion and payload delivery

Autor: Yeow, Yen Ling, Kotamraju, Venkata Ramana, Wang, Xiao, Chopra, Meenu, Azme, Nasibah, Wu, Jiansha, Schoep, Tobias D, Delaney, Derek S, Feindel, Kirk, Li, Ji, Kennedy, Kelsey M, Allen, Wes M, Kennedy, Brendan F, Larma, Irma, Sampson, David D, Mahakian, Lisa M, Fite, Brett Z, Zhang, Hua, Friman, Tomas, Mann, Aman P, Aziz, Farah A, Kumarasinghe, M Priyanthi, Johansson, Mikael, Ee, Hooi C, Yeoh, George, Mou, Lingjun, Ferrara, Katherine W, Billiran, Hector, Ganss, Ruth, Ruoslahti, Erkki, Hamzah, Juliana

Publikováno v: EMBO molecular medicine, vol 11, iss 12

High extracellular matrix (ECM) content in solid cancers impairs tumour perfusion and thus access of imaging and therapeutic agents. We have devised a new approach to degrade tumour ECM, which improves uptake of circulating compounds. We target the i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::2bfca2b5e00628583a568b0128cb96cd
https://escholarship.org/uc/item/38d5q96s

Immune-mediated ECM depletion improves tumour perfusion and payload delivery.

Autor: Yeow YL; Harry Perkins Institute of Medical Research, Centre for Medical Research, QEII Medical Centre, The University of Western Australia, Perth, WA, Australia., Kotamraju VR; Cancer Research Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA., Wang X; Harry Perkins Institute of Medical Research, Centre for Medical Research, QEII Medical Centre, The University of Western Australia, Perth, WA, Australia., Chopra M; Harry Perkins Institute of Medical Research, Centre for Medical Research, QEII Medical Centre, The University of Western Australia, Perth, WA, Australia., Azme N; Harry Perkins Institute of Medical Research, Centre for Medical Research, QEII Medical Centre, The University of Western Australia, Perth, WA, Australia., Wu J; Harry Perkins Institute of Medical Research, Centre for Medical Research, QEII Medical Centre, The University of Western Australia, Perth, WA, Australia., Schoep TD; Telethon Kids Institute, Subiaco, WA, Australia., Delaney DS; Harry Perkins Institute of Medical Research, Centre for Medical Research, QEII Medical Centre, The University of Western Australia, Perth, WA, Australia., Feindel K; Centre for Microscopy, Characterisation & Analysis, The University of Western Australia, Perth, WA, Australia., Li J; Harry Perkins Institute of Medical Research, Centre for Medical Research, QEII Medical Centre, The University of Western Australia, Perth, WA, Australia., Kennedy KM; Department of Electrical, Electronic & Computer Engineering, School of Engineering, The University of Western Australia, Perth, WA, Australia., Allen WM; Harry Perkins Institute of Medical Research, Centre for Medical Research, QEII Medical Centre, The University of Western Australia, Perth, WA, Australia.; Department of Electrical, Electronic & Computer Engineering, School of Engineering, The University of Western Australia, Perth, WA, Australia., Kennedy BF; Harry Perkins Institute of Medical Research, Centre for Medical Research, QEII Medical Centre, The University of Western Australia, Perth, WA, Australia.; Department of Electrical, Electronic & Computer Engineering, School of Engineering, The University of Western Australia, Perth, WA, Australia., Larma I; Centre for Microscopy, Characterisation & Analysis, The University of Western Australia, Perth, WA, Australia., Sampson DD; Centre for Microscopy, Characterisation & Analysis, The University of Western Australia, Perth, WA, Australia.; Department of Electrical, Electronic & Computer Engineering, School of Engineering, The University of Western Australia, Perth, WA, Australia., Mahakian LM; Department of Biomedical Engineering, University of California Davis, Davis, CA, USA., Fite BZ; Department of Biomedical Engineering, University of California Davis, Davis, CA, USA., Zhang H; Department of Biomedical Engineering, University of California Davis, Davis, CA, USA., Friman T; Cancer Research Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA., Mann AP; Cancer Research Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA., Aziz FA; Sir Charles Gairdner Hospital, Perth, WA, Australia., Kumarasinghe MP; PathWest Laboratory Medicine, QE2 Medical Centre, Perth, WA, Australia., Johansson M; Sir Charles Gairdner Hospital, Perth, WA, Australia., Ee HC; Sir Charles Gairdner Hospital, Perth, WA, Australia., Yeoh G; Harry Perkins Institute of Medical Research, Centre for Medical Research, QEII Medical Centre, The University of Western Australia, Perth, WA, Australia., Mou L; Sir Charles Gairdner Hospital, Perth, WA, Australia., Ferrara KW; Department of Biomedical Engineering, University of California Davis, Davis, CA, USA., Billiran H; Cancer Research Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA., Ganss R; Harry Perkins Institute of Medical Research, Centre for Medical Research, QEII Medical Centre, The University of Western Australia, Perth, WA, Australia., Ruoslahti E; Cancer Research Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA., Hamzah J; Harry Perkins Institute of Medical Research, Centre for Medical Research, QEII Medical Centre, The University of Western Australia, Perth, WA, Australia.

Publikováno v: EMBO molecular medicine [EMBO Mol Med] 2019 Dec; Vol. 11 (12), pp. e10923. Date of Electronic Publication: 2019 Nov 11.