Genetics of the thrombomodulin-endothelial cell protein C receptor system and the risk of early-onset ischemic stroke.

Autor: John W Cole, Huichun Xu, Kathleen Ryan, Thomas Jaworek, Nicole Dueker, Patrick McArdle, Brady Gaynor, Yu-Ching Cheng, Jeffrey O'Connell, Steve Bevan, Rainer Malik, Naveed Uddin Ahmed, Philippe Amouyel, Sheraz Anjum, Joshua C Bis, David Crosslin, John Danesh, Stefan T Engelter, Myriam Fornage, Philippe Frossard, Christian Gieger, Anne-Katrin Giese, Caspar Grond-Ginsbach, Weang Kee Ho, Elizabeth Holliday, Jemma Hopewell, M Hussain, W Iqbal, S Jabeen, Jim Jannes, Ayeesha Kamal, Yoichiro Kamatani, Sandip Kanse, Manja Kloss, Mark Lathrop, Didier Leys, Arne Lindgren, W T Longstreth, Khalid Mahmood, Christa Meisinger, Tiina M Metso, Thomas Mosley, Martina Müller-Nurasyid, Bo Norrving, Eugenio Parati, Annette Peters, Alessandro Pezzini, I Quereshi, Asif Rasheed, A Rauf, T Salam, Jess Shen, Agnieszka Słowik, Tara Stanne, Konstantin Strauch, Turgut Tatlisumak, Vincent N Thijs, Steffen Tiedt, Matthew Traylor, Melanie Waldenberger, Matthew Walters, Wei Zhao, Giorgio Boncoraglio, Stéphanie Debette, Christina Jern, Christopher Levi, Hugh Markus, James Meschia, Arndt Rolfs, Peter Rothwell, Danish Saleheen, Sudha Seshadri, Pankaj Sharma, Cathie Sudlow, Bradford Worrall, METASTROKE Consortium of the ISGC, WTCCC-2 Consortium, O Colin Stine, Steven J Kittner, Braxton D Mitchell

Publikováno v: PLoS ONE, Vol 13, Iss 11, p e0206554 (2018)

Background and purposePolymorphisms in coagulation genes have been associated with early-onset ischemic stroke. Here we pursue an a priori hypothesis that genetic variation in the endothelial-based receptors of the thrombomodulin-protein C system (TH

Externí odkaz: https://doaj.org/article/d7e9695d35ae48c8af23ab47b2c3c8b2

Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations.

Autor: Melanie Kolz, Toby Johnson, Serena Sanna, Alexander Teumer, Veronique Vitart, Markus Perola, Massimo Mangino, Eva Albrecht, Chris Wallace, Martin Farrall, Asa Johansson, Dale R Nyholt, Yurii Aulchenko, Jacques S Beckmann, Sven Bergmann, Murielle Bochud, Morris Brown, Harry Campbell, EUROSPAN Consortium, John Connell, Anna Dominiczak, Georg Homuth, Claudia Lamina, Mark I McCarthy, ENGAGE Consortium, Thomas Meitinger, Vincent Mooser, Patricia Munroe, Matthias Nauck, John Peden, Holger Prokisch, Perttu Salo, Veikko Salomaa, Nilesh J Samani, David Schlessinger, Manuela Uda, Uwe Völker, Gérard Waeber, Dawn Waterworth, Rui Wang-Sattler, Alan F Wright, Jerzy Adamski, John B Whitfield, Ulf Gyllensten, James F Wilson, Igor Rudan, Peter Pramstaller, Hugh Watkins, PROCARDIS Consortium, Angela Doering, H-Erich Wichmann, KORA Study, Tim D Spector, Leena Peltonen, Henry Völzke, Ramaiah Nagaraja, Peter Vollenweider, Mark Caulfield, WTCCC, Thomas Illig, Christian Gieger

Publikováno v: PLoS Genetics, Vol 5, Iss 6, p e1000504 (2009)

Elevated serum uric acid levels cause gout and are a risk factor for cardiovascular disease and diabetes. To investigate the polygenetic basis of serum uric acid levels, we conducted a meta-analysis of genome-wide association scans from 14 studies to

Externí odkaz: https://doaj.org/article/ff4cc331981e449292132db7bb00d13e

Replication of Genome-Wide Association Signals in UK Samples Reveals Risk Loci for Type 2 Diabetes

Autor: The Wellcome Trust Case Control Consortium (WTCCC), Zeggini, Eleftheria, Weedon, Michael N., Lindgren, Cecilia M., Frayling, Timothy M., Elliott, Katherine S., Lango, Hana, Timpson, Nicholas J., Perry, John R. B., Rayner, Nigel W., Freathy, Rachel M., Barrett, Jeffrey C., Shields, Beverley, Morris, Andrew P., Ellard, Sian, Groves, Christopher J., Harries, Lorna W., Marchini, Jonathan L., Owen, Katharine R., Knight, Beatrice, Cardon, Lon R., Walker, Mark, Hitman, Graham A., Morris, Andrew D., Doney, Alex S. F., McCarthy, Mark I., Hattersley, Andrew T.

Publikováno v: Science, 2007 Jun 01. 316(5829), 1336-1341.

Externí odkaz: https://www.jstor.org/stable/20036395

Significant enrichment of Herpesvirus interactors in GWAS data suggests causal inferences for the association between Epstein Barr virus and multiple sclerosis

Autor: Rosella Mechelli, Imsgc, Arianna Fornasiero, Cinthia Farina, Diego Centonze, Renato Umeton, Giovanni Ristori, Michela Ferraldeschi, Marco Salvetti, Wtccc, Sundararajan Srinivasan

SUMMARYWe exploited genetic information to assess the role of non-genetic factors in multifactorial diseases. To this aim we isolated candidate “interactomes” (i.e. groups of genes whose products are known to physically interact with environmenta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adc50ba5a9b18c3f577343c94e6603ef
https://doi.org/10.1101/624049

Large-scale replication typing of modest signals from genome-wide association studies identifies additional type 2 diabetes susceptibility variants in the IGF2BP2 and VEGFA genes

Autor: Zeggini, E, Weedon, M, Lindgren, C, Frayling, T, Elliott, K, Lango, H, Timpson, N, Perry, J, Rayner, N, Freathy, R, Barrett, J, Groves, C, Morris, A, Hattersley, A, McCarthy, M, Consort, U, WTCCC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1064::755de1b4fa57550a4cab7ea68db44494
https://ora.ox.ac.uk/objects/uuid:e52eab56-6752-41d9-b7fc-60493e62a2c4