The association of upper airway anatomy with cognitive test performance: the Multi-Ethnic Study of Atherosclerosis

Autor: Robin M. Nance, Alison E. Fohner, Robyn L. McClelland, Susan Redline, R. Nick Bryan, Annette Fitzpatrick, Mohamad Habes, WT Longstreth, Jr., Richard J. Schwab, Andrew S. Wiemken, Susan R. Heckbert

Publikováno v: BMC Neurology, Vol 23, Iss 1, Pp 1-9 (2023)

Abstract Background Numerous upper airway anatomy characteristics are risk factors for sleep apnea, which affects 26% of older Americans, and more severe sleep apnea is associated with cognitive impairment. This study explores the pathophysiology and

Externí odkaz: https://doaj.org/article/ab99c0dc106049c690ae450645d44d2c

Genomic analysis of intracranial and subcortical brain volumes yields polygenic scores accounting for variation across ancestries.

Autor: García-Marín LM; Brain and Mental Health Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.; School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia., Campos AI; Brain and Mental Health Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.; Institute for Molecular Biosciences, The University of Queensland, Brisbane, Queensland, Australia., Diaz-Torres S; School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.; Population Health Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Rabinowitz JA; Department of Psychiatry, Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ, USA., Ceja Z; Brain and Mental Health Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.; School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia., Mitchell BL; Brain and Mental Health Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.; School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia., Grasby KL; Brain and Mental Health Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.; School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia., Thorp JG; Brain and Mental Health Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Agartz I; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.; Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway.; Department of Clinical Neuroscience, Karolinska Institutet and Stockholm Health Care Services, Stockholm, Sweden., Alhusaini S; Department of Neurology, Alpert Medical School of Brown University, Providence, RI, USA.; Molecular and Cellular Therapeutics Department, Royal College of Surgeons in Ireland, Dublin, Ireland., Ames D; Academic Unit Psychiatry of Old Age, University of Melbourne, Melbourne, Victoria, Australia.; National Ageing Research Institute, Parkville, Victoria, Australia., Amouyel P; Universite Lille, U1167-RID-AGE-LabEx DISTALZ-Risk Factors and Molecular Determinants of Aging Diseases, Lille, France.; Institut National de la Santé et de la Recherche Médicale, Lille, France.; Centre Hospitalier Universitaire de Lille Department of Public Health, Lille, France.; Institut Pasteur de Lille UMR1167, Lille, France., Andreassen OA; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.; Centre for Precision Psychiatry, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; KG Jebsen Centre for Neurodevelopmental Disorders, University of Oslo, Oslo, Norway., Arfanakis K; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.; Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, USA., Arias-Vasquez A; Departments of Psychiatry and Human Genetics, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands., Armstrong NJ; Department of Mathematics and Statistics, Curtin University, Perth, Western Australia, Australia., Athanasiu L; Centre for Precision Psychiatry, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; CoE NORMENT, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway., Bastin ME; Centre for Clinical Brain Sciences and Edinburgh Imaging, University of Edinburgh, Edinburgh, UK., Beiser AS; Department of Biostatistics, School of Public Health, Boston University, Boston, MA, USA.; Framingham Heart Study, Chobanian and Avedisian Boston University School of Medicine, Boston, MA, USA., Bennett DA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA., Bis JC; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Boks MPM; Brain Center University Medical Center Utrecht, Utrecht, The Netherlands., Boomsma DI; Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU Amsterdam, Amsterdam, The Netherlands., Brodaty H; Centre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales, Sydney, New South Wales, Australia., Brouwer RM; Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU Amsterdam, Amsterdam, The Netherlands., Buitelaar JK; Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands., Burkhardt R; Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, Regensburg University, Regensburg, Germany.; LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany., Cahn W; Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands.; Altrecht Mental Health Institute, Utrecht, The Netherlands., Calhoun VD; Tri-institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS)-Georgia State, Georgia Tech and Emory University, Atlanta, GA, USA., Carmichael OT; Pennington Biomedical Research Center, Baton Rouge, LA, USA., Chakravarty M; Cerebral Imaging Centre, Douglas Research Centre, Montreal, Quebec, Canada.; Department of Psychiatry, McGill University, Montreal, Quebec, Canada., Chen Q; Lieber Institute for Brain Development, Baltimore, MD, USA., Ching CRK; Laboratory of Neuro Imaging, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA., Cichon S; Institute of Neuroscience and Medicine (INM-1), Research Center Jülich, Jülich, Germany.; Department of Biomedicine, University of Basel, Basel, Switzerland.; Medical Genetics, Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland., Crespo-Facorro B; HU Virgen del Rocio, Instituto de Investigacion Biomedica IBIS-CSIC, Universidad de Sevilla, CIBERSAM, Sevilla, Spain., Crivello F; CNRS, IMN, UMR 5293, University of Bordeaux, Bordeaux, France., Dale AM; Center for Multimodal Imaging and Genetics, La Jolla, CA, USA., Smith GD; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Population Health Sciences, University of Bristol, Bristol, UK., de Geus EJC; Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., De Jager PL; Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York City, NY, USA., de Zubicaray GI; School of Psychology and Counselling, Queensland University of Technology, Brisbane, Queensland, Australia., Debette S; INSERM U1219, Bordeaux Population Health Research Center, University of Bordeaux, Bordeaux, France.; Department of Neurology, Institute of Neurodegenerative Diseases, Bordeaux University Hospital, Bordeaux, France., DeCarli C; Imaging of Dementia and Aging Laboratory, Department of Neurology, University of California, Davis, Sacramento, CA, USA., Depondt C; Department of Neurology, Hôpital Universitaire de Bruxelles, Université Libre de Bruxelles, Brussels, Belgium., Desrivières S; Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Djurovic S; Department of Medical Genetics, Oslo University Hospital, Oslo, Norway.; Department of Clinical Science, University of Bergen, Bergen, Norway., Ehrlich S; Translational Developmental Neuroscience Section, Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, TU Dresden, Dresden, Germany., Erk S; German Center of Mental Health (DZPG), Partner Site Berlin/Potsdam, Berlin, Germany.; Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Espeseth T; Department of Psychology, University of Oslo, Oslo, Norway.; Department of Psychology, Oslo New University College, Oslo, Norway., Fernández G; Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands., Filippi I; INSERM U1299, Paris Saclay University, Gif-sur-Yvette, France., Fisher SE; Language and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands.; Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands., Fleischman DA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.; Department of Psychiatry and Behavioral Sciences, Rush University Medical Center, Chicago, IL, USA., Fletcher E; Department of Neurology, University of California, Davis, Davis, CA, USA., Fornage M; Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA., Forstner AJ; Institute of Neuroscience and Medicine (INM-1), Research Center Jülich, Jülich, Germany.; Institute of Human Genetics, University of Bonn, School of Medicine and University Hospital Bonn, Bonn, Germany., Francks C; Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.; Language and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands.; Department of Cognitive Neuroscience, Radboud University Medical Center, Nijmegen, The Netherlands., Franke B; Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.; Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands., Ge T; Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA., Goldman AL; Lieber Institute for Brain Development, Baltimore, MD, USA., Grabe HJ; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany., Green RC; Department of Medicine (Genetics), Mass General Brigham and Harvard Medical School, Boston, MA, USA., Grimm O; Central Institute of Mental Health, Mannheim, Germany.; Goethe-University Frankfurt, Frankfurt, Germany., Groenewold NA; Department of Psychiatry and Mental Health, Neuroscience Institute, University of Cape Town, Cape Town, South Africa., Gruber O; Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University, Heidelberg, Germany., Gudnason V; Icelandic Heart Association, Kopavogur, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Håberg AK; Department of Neuromedicine and Movement, NTNU Science, Trondheim, Norway.; MiDT National Research Center, Department of Research, St Olavs Hospital, Trondheim, Norway., Haukvik UK; Norwegian Centre for Mental Health Research (NORMENT), Department of Mental Health and Addiction, University of Oslo, Oslo, Norway.; Centre for Forensic Psychiatry Research, Oslo University Hospital, Oslo, Norway., Heinz A; German Center of Mental Health (DZPG), Partner Site Berlin/Potsdam, Berlin, Germany.; Centre for Forensic Psychiatry Research, Oslo University Hospital, Oslo, Norway., Hibar DP; Product Development, Genentech, Inc., South San Francisco, CA, USA., Hilal S; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore City, Singapore., Himali JJ; Department of Biostatistics, School of Public Health, Boston University, Boston, MA, USA.; Framingham Heart Study, Chobanian and Avedisian Boston University School of Medicine, Boston, MA, USA.; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX, USA.; Department of Population Health Sciences, UT Health Science Center San Antonio, San Antonio, TX, USA.; Department of Neurology, Boston University School of Medicine, Boston, MA, USA., Ho BC; Department of Psychiatry, Carver College of Medicine, University of Iowa, Iowa City, IA, USA., Hoehn DF; Max Planck Institute of Psychiatry, Munich, Germany., Hoekstra PJ; Department of Child and Adolescent Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.; Accare Child Study Center, Groningen, The Netherlands., Hofer E; Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, Austria.; Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, Austria., Hoffmann W; German Centre for Neurodegenerative Diseases (DZNE)-Site Rostock/Greifswald, Greifswald, Germany.; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany., Holmes AJ; Department of Psychiatry, Brain Health Institute, Rutgers University, Piscataway, NJ, USA., Homuth G; Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany., Hosten N; Department of Radiology, University Clinic Greifswald, Greifswald, Germany., Ikram MK; Departments of Epidemiology and Neurology, Erasmus MC, Rotterdam, The Netherlands., Ipser JC; Department of Psychiatry and Mental Health, Neuroscience Institute, Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa., Jack CR Jr; Department of Radiology, Mayo Clinic, Rochester, MN, USA., Jahanshad N; Laboratory of Neuro Imaging, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA., Jönsson EG; Centre for Precision Psychiatry, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet and Stockholm Health Care Sciences, Stockholm Region, Stockholm, Sweden., Kahn RS; Altrecht Mental Health Institute, Utrecht, The Netherlands., Kanai R; Araya, Inc, Tokyo, Japan., Klein M; Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.; Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands., Knol MJ; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands., Launer LJ; Intramural Research Program, National Institute on Aging, Baltimore, MD, USA., Lawrie SM; Division of Psychiatry, University of Edinburgh, Edinburgh, UK., Hellard SL; Department of Clinical Science, University of Bergen, Bergen, Norway., Lee PH; Center for Genomic Medicine, Mass General Brigham, Boston, MA, USA.; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.; Stanley Center for Psychiatry, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Lemaître H; Groupe d'Imagerie Neurofonctionnelle, Institut des Maladies Neurodégénératives, UMR 5293, CNRS, Université de Bordeaux, Bordeaux, France., Li S; Department of Biostatistics, School of Public Health, Boston University, Boston, MA, USA.; Framingham Heart Study, Chobanian and Avedisian Boston University School of Medicine, Boston, MA, USA., Liewald DCM; PPLS, University of Edinburgh, Edinburgh, UK., Lin H; Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA., Longstreth WT Jr; Department of Neurology, University of Washington, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA., Lopez OL; Departments of Neurology and Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Luciano M; Department of Psychology, University of Edinburgh, Edinburgh, UK., Maillard P; Department of Neurology, University of California, Davis, Davis, CA, USA., Marquand AF; Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands., Martin NG; Brain and Mental Health Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Martinot JL; Université Paris-Saclay, Institut National de la Santé et de la Recherche Médicale, INSERM U1299 'Trajectoires développementales Psychiatrie', Ecole Normale Supérieure Paris-Saclay, CNRS UMR 9010, Université Paris Cité, Centre Borelli, Gif sur Yvette, France., Mather KA; Centre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales, Sydney, New South Wales, Australia., Mattay VS; Lieber Institute for Brain Development, Baltimore, MD, USA., McMahon KL; School of Clinical Sciences, Queensland University of Technology, Brisbane, Queensland, Australia., Mecocci P; Institute of Gerontology and Geriatrics, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.; Clinical Geriatrics, NVS Department, Karolinska Institute, Huddinge, Sweden., Melle I; Centre for Precision Psychiatry, Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Meyer-Lindenberg A; Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Mirza-Schreiber N; Institute of Neurogenomics, Helmholtz Munich, Neuherberg, Germany.; Neurogenetic Systems Analysis Group, Institute of Neurogenomics, Helmholtz Munich, Neuherberg, Germany., Milaneschi Y; Department of Psychiatry, Amsterdam UMC location Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Amsterdam Public Health, Mental Health Program, Amsterdam, The Netherlands.; Amsterdam Neuroscience, Mood, Anxiety, Psychosis, Sleep and Stress Program, Amsterdam, The Netherlands.; Amsterdam Neuroscience, Complex Trait Genetics Program, Amsterdam, The Netherlands., Mosley TH; MIND Center, Jackson, MS, USA., Mühleisen TW; Institute of Neuroscience and Medicine (INM-1), Research Center Jülich, Jülich, Germany.; Cécile and Oskar Vogt Institute for Brain Research, Medical Faculty, University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.; Department of Biomedicine, University Hospital Basel and University of Basel, Basel, Switzerland., Müller-Myhsok B; Statistics Genetics Group, Max Planck Institute of Psychiatry, Munich, Germany., Maniega SM; Centre for Clinical Brain Sciences and Edinburgh Imaging, University of Edinburgh, Edinburgh, UK., Nauck M; Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany.; German Centre for Cardiovascular Research (DZHK), Partner Site Greifswald, Greifswald, Germany., Nho K; Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA.; Indiana Alzheimer's Disease Research Center, Indiana University School of Medicine, Indianapolis, IN, USA., Niessen WJ; University Medical Center Groningen, Groningen, The Netherlands., Nöthen MM; Institute of Human Genetics, University of Bonn, School of Medicine and University Hospital Bonn, Bonn, Germany., Nyquist PA; Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, USA.; General Internal Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA., Oosterlaan J; Clinical Neuropsychology Section, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Emma Children's Hospital, University Medical Centers Amsterdam, Amsterdam, The Netherlands.; Amsterdam Reproduction and Development Research Institute, Amsterdam, The Netherlands., Pandolfo M; Université Libre de Bruxelles, Brussels, Belgium.; Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada., Paus T; Departments of Psychiatry and Neuroscience, Faculty of Medicine, University of Montreal, Montreal, Quebec, Canada.; Centre Hospitalier Universitaire Sainte-Justine, University of Montreal, Montreal, Quebec, Canada., Pausova Z; Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Physiology, University of Toronto, Toronto, Ontario, Canada., Penninx BWJH; Department of Psychiatry, Amsterdam UMC location Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Pike GB; Departments of Radiology and Clinical Neurosciences, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada., Psaty BM; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Department of Health Systems and Population Health, Seattle, WA, USA., Pütz B; Translational Psychiatry, Munich, Germany., Reppermund S; Centre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales, Sydney, New South Wales, Australia.; Department of Developmental Disability Neuropsychiatry, Discipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales, Sydney, New South Wales, Australia., Rietschel MD; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Faculty of Medicine Mannheim, University of Heidelberg, Mannheim, Germany., Risacher SL; Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA.; Indiana Alzheimer's Disease Research Center, Indiana University School of Medicine, Indianapolis, IN, USA., Romanczuk-Seiferth N; Department of Psychiatry and Neuroscience, Charité-Universitätsmedizin Berlin, Berlin, Germany.; Department of Psychology, Clinical Psychology and Psychotherapy, MSB Medical School Berlin, Berlin, Germany., Romero-Garcia R; Departamento de Fisiología Médica y Biofísica, Instituto de Biomedicina de Sevilla (IBiS) HUVR/CSIC/Universidad de Sevilla/CIBERSAM, ISCIII, Sevilla, Spain.; Department of Psychiatry, University of Cambridge, Cambridge, UK., Roshchupkin GV; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.; Department of Radiology and Nuclear Medicine, Erasmus MC University Medical Center, Rotterdam, The Netherlands., Rotter JI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Sachdev PS; Centre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales, Sydney, New South Wales, Australia.; Neuropsychiatric Institute, The Prince of Wales Hospital, Randwick, New South Wales, Australia., Sämann PG; Max Planck Institute of Psychiatry, Munich, Germany., Saremi A; Laboratory of Neuro Imaging, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA., Sargurupremraj M; INSERM U1219, Bordeaux Population Health Research Center, University of Bordeaux, Bordeaux, France.; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX, USA., Saykin AJ; Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA.; Indiana Alzheimer's Disease Research Center, Indiana University School of Medicine, Indianapolis, IN, USA., Schmaal L; Centre for Youth Mental Health, The University of Melbourne, Parkville, Victoria, Australia.; Orygen, Parkville, Victoria, Australia., Schmidt H; Institute of Molecular Biology and Biochemistry, Gottfried Schatz Center for Signaling, Metabolism and Aging, Medical University Graz, Graz, Austria., Schmidt R; Department of Neurology, Medical University Graz Austria, Graz, Austria., Schofield PR; Neuroscience Research Australia, Sydney, New South Wales, Australia.; School of Biomedical Sciences, University of New South Wales, Sydney, New South Wales, Australia., Scholz M; LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany.; Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany., Schumann G; German Center of Mental Health (DZPG), Partner Site Berlin/Potsdam, Berlin, Germany.; Department of Psychiatry, University of Cambridge, Cambridge, UK.; Centre for Population Neuroscience and Stratified Medicine (PONS), ISTBI, Fudan University, Shanghai, PR China.; PONS Centre, Department of Psychiatry, CCM, Charite Unversitaetsmedizin Berlin, Berlin, Germany., Schwarz E; Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Shen L; Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Shin J; The Hospital for Sick Children, Departments of Physiology and Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada., Sisodiya SM; Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, UK.; Chalfont Centre for Epilepsy, Chalfont St Peter, UK., Smith AV; Icelandic Heart Association, Kopavogur, Iceland.; Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA., Smoller JW; Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA., Soininen HS; Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland., Steen VM; Department of Clinical Science, University of Bergen, Bergen, Norway.; Dr. Einar Martens Research Group for Biological Psychiatry, Department of Medical Genetics, Haukeland University Hospital, Bergen, Norway., Stein DJ; SAMRC Research Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa., Stein JL; Department of Genetics and UNC Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Thomopoulos SI; Laboratory of Neuro Imaging, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA., Toga AW; Laboratory of Neuro Imaging, USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA., Tordesillas-Gutiérrez D; Instituto de Física de Cantabria (CSIC-UC), Santander, Spain.; Department of Radiology, Marqués de Valdecilla University Hospital, Valdecilla Biomedical Research Institute IDIVAL, Santander, Spain., Trollor JN; Centre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales, Sydney, New South Wales, Australia.; The National Centre of Excellence in Intellectual Disability Health, Faculty of Medicine and Health, University of New South Wales, Sydney, New South Wales, Australia., Valdes-Hernandez MC; Centre for Clinical Brain Sciences and Edinburgh Imaging, University of Edinburgh, Edinburgh, UK., van T Ent D; Department of Biological Psychology and Netherlands Twin Register, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., van Bokhoven H; Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.; Department of Human Genetics, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands., van der Meer D; Centre for Precision Psychiatry, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; School of Mental Health and Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands., van der Wee NJA; Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands., Vázquez-Bourgon J; Department of Psychiatry, University Hospital Marqués de Valdecilla-IDIVAL, Santander, Spain.; Departamento de Medicina y Psiquiatría, Universidad de Cantabria, Santander, Spain.; Centro de Investigación Biomédica en Red en Salud Mental (CIBERSAM), Sevilla, Spain., Veltman DJ; Department of Psychiatry, Amsterdam UMC location Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Vernooij MW; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.; Department of Radiology and Nuclear Medicine, Erasmus MC University Medical Center, Rotterdam, The Netherlands., Villringer A; Department of Neurology, Max Planck Institute for Human, Cognitive and Brain Sciences, Leipzig, Germany.; Cognitive Neurology, University of Leipzig Medical Center, Leipzig, Germany., Vinke LN; Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA., Völzke H; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany., Walter H; Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Wardlaw JM; Centre for Clinical Brain Sciences and Edinburgh Imaging, University of Edinburgh, Edinburgh, UK.; UK Dementia Research Institute Centre, University of Edinburgh, Edinburgh, UK., Weinberger DR; Lieber Institute for Brain Development, Baltimore, MD, USA.; Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, USA.; Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, MD, USA.; Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD, USA.; Genetic Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA., Weiner MW; University of California, San Francisco, San Francisco, CA, USA.; Northern California Institute for Research and Education (NCIRE), San Francisco, CA, USA.; Veterans Administration Medical Center, San Francisco, CA, USA., Wen W; Centre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales, Sydney, New South Wales, Australia., Westlye LT; Centre for Precision Psychiatry, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Department of Psychology, University of Oslo, Oslo, Norway., Westman E; Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society (NVS), Karolinska Institutet, Huddinge, Sweden., White T; Section on Social and Cognitive Developmental Neuroscience, National Institute of Mental Health, Bethesda, MD, USA., Witte AV; Department of Neurology, Max Planck Institute for Human, Cognitive and Brain Sciences, Leipzig, Germany.; Cognitive Neurology, University of Leipzig Medical Center, Leipzig, Germany., Wolf C; Max Planck Institute of Psychiatry, Munich, Germany., Yang J; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA., Zwiers MP; Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands., Ikram MA; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands., Seshadri S; Framingham Heart Study, Chobanian and Avedisian Boston University School of Medicine, Boston, MA, USA.; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX, USA., Thompson PM; Laboratory of Neuro Imaging, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA., Satizabal CL; Framingham Heart Study, Chobanian and Avedisian Boston University School of Medicine, Boston, MA, USA.; Department of Population Health Sciences and Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, UT Health San Antonio, San Antonio, TX, USA.; Department of Neurology, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA., Medland SE; Brain and Mental Health Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.; School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.; School of Psychology and Counselling, Queensland University of Technology, Brisbane, Queensland, Australia.; School of Psychology, The University of Queensland, Brisbane, Queensland, Australia., Rentería ME; Brain and Mental Health Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. miguel.renteria@qimrberghofer.edu.au.; School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia. miguel.renteria@qimrberghofer.edu.au.

Publikováno v: Nature genetics [Nat Genet] 2024 Nov; Vol. 56 (11), pp. 2333-2344. Date of Electronic Publication: 2024 Oct 21.

Apixaban vs Aspirin in Patients With Cancer and Cryptogenic Stroke: A Post Hoc Analysis of the ARCADIA Randomized Clinical Trial.

Autor: Navi BB; Clinical and Translational Neuroscience Unit, Feil Family Brain and Mind Research Institute and Department of Neurology, Weill Cornell Medicine, New York, New York.; Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, New York., Zhang C; Clinical and Translational Neuroscience Unit, Feil Family Brain and Mind Research Institute and Department of Neurology, Weill Cornell Medicine, New York, New York., Miller B; Department of Neurology, University of Minnesota, Minneapolis., Cushman M; Division of Hematology and Oncology, Department of Medicine, University of Vermont Larner College of Medicine, Burlington., Kasner SE; Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia., Elkind MSV; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York.; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York., Tirschwell DL; Department of Neurology, University of Washington, Seattle., Longstreth WT Jr; Department of Neurology, University of Washington, Seattle.; Department of Epidemiology, University of Washington, Seattle., Kronmal RA; Department of Biostatistics, University of Washington, Seattle., Beyeler M; Clinical and Translational Neuroscience Unit, Feil Family Brain and Mind Research Institute and Department of Neurology, Weill Cornell Medicine, New York, New York.; Department of Neurology, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland., Elm J; Department of Biostatistics, Medical University of South Carolina, Charleston., Zweifler RM; Ochsner Neuroscience Institute, Ochsner Health, New Orleans, Louisiana., Tarsia J; Ochsner Neuroscience Institute, Ochsner Health, New Orleans, Louisiana., Cereda CW; Department of Neurology, Neurocenter of Southern Switzerland EOC, Lugano, Switzerland., Bianco G; Department of Neurology, Neurocenter of Southern Switzerland EOC, Lugano, Switzerland., Costamagna G; Stroke Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.; Neurology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy., Michel P; Department of Clinical Neurosciences, University of Lausanne, Lausanne, Switzerland., Broderick JP; Department of Neurology and Rehabilitation Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio., Gladstone DJ; Sunnybrook Research Institute, Hurvitz Brain Sciences Program, Sunnybrook Health Sciences Centre, and Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada., Kamel H; Clinical and Translational Neuroscience Unit, Feil Family Brain and Mind Research Institute and Department of Neurology, Weill Cornell Medicine, New York, New York.; Deputy Editor, JAMA Neurology., Streib C; Department of Neurology, University of Minnesota, Minneapolis.

Publikováno v: JAMA neurology [JAMA Neurol] 2024 Sep 01; Vol. 81 (9), pp. 958-965.

Circulating sphingolipids in relation to cognitive decline and incident dementia: The Cardiovascular Health Study.

Autor: Moseholm KF; Department of Public Health Section of Epidemiology University of Copenhagen Copenhagen Denmark., Cronjé HT; Department of Public Health Section of Epidemiology University of Copenhagen Copenhagen Denmark., Koch M; Department of Nutrition Harvard T.H. Chan School of Public Health Boston Massachusetts USA., Fitzpatrick AL; Departments of Family Medicine and Epidemiology School of Public Health University of Washington Seattle Washington USA., Lopez OL; Department of Neurology School of Medicine University of Pittsburgh Pittsburgh Pennsylvania USA., Otto MCO; Department of Epidemiology University of Texas Health Science Center Houston Texas USA., Longstreth WT Jr; Departments of Family Medicine and Epidemiology School of Public Health University of Washington Seattle Washington USA.; Department of Neurology School of Medicine University of Washington Seattle Washington USA., Hoofnagle AN; Department of Laboratory Medicine and Pathology School of Medicine University of Washington Seattle Washington USA., Mukamal KJ; Department of Medicine Beth Israel Deaconess Medical Center Boston Massachusetts USA., Lemaitre RN; Cardiovascular Health Research Unit, Department of Medicine University of Washington Seattle Washington USA., Jensen MK; Department of Public Health Section of Epidemiology University of Copenhagen Copenhagen Denmark.; Department of Nutrition Harvard T.H. Chan School of Public Health Boston Massachusetts USA.

Publikováno v: Alzheimer's & dementia (Amsterdam, Netherlands) [Alzheimers Dement (Amst)] 2024 Aug 08; Vol. 16 (3), pp. e12623. Date of Electronic Publication: 2024 Aug 08 (Print Publication: 2024).

The Association of Upper Airway Anatomy with Brain Structure: The Multi-Ethnic Study of Atherosclerosis.

Autor: Nance RM; University of Washington, Seattle, WA, USA. rmnance@uw.edu.; 325 9th Ave, Box 359931, Seattle, WA, 98104, USA. rmnance@uw.edu., Fohner AE; Department of Epidemiology & Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA., McClelland RL; Department of Biostatistics, University of Washington, Seattle, WA, USA., Redline S; Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Nick Bryan R; Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA., Desiderio L; University of Pennsylvania, Philadelphia, PA, USA., Habes M; Neuroimage Analytics Laboratory and Biggs Institute Neuroimaging Core, Glenn Biggs Institute for Neurodegenerative Disorders, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA., Longstreth WT Jr; Departments of Neurology and Epidemiology, University of Washington, Seattle, WA, USA., Schwab RJ; Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Wiemken AS; Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Heckbert SR; University of Washington, Seattle, WA, USA.

Publikováno v: Brain imaging and behavior [Brain Imaging Behav] 2024 Jun; Vol. 18 (3), pp. 510-518. Date of Electronic Publication: 2024 Jan 09.