A progesterone derivative linked to a stable phospholipid activates breast cancer cell response without leaving the cell membrane.

Autor: Font-Mateu J; Center for Genomic Regulation (CRG), Barcelona Institute for Science and Technology (BIST), Barcelona, Spain., Sanllehí P; Center for Genomic Regulation (CRG), Barcelona Institute for Science and Technology (BIST), Barcelona, Spain.; Department of Biological Chemistry, Institute for Advanced Chemistry of Catalonia, IQAC-CSIC, Jordi Girona 18-26, 08034, Barcelona, Spain., Sot J; Instituto Biofisika (UPV/EHU, CSIC), Barrio Sarriena s/n, 48940, Leioa, Spain., Abad B; SGIKER, Universidad del País Vasco, Barrio Sarriena s/n, 48940, Leioa, Spain., Mateos N; The Barcelona Institute for Science and Technology (BIST), ICFO-Institut de Ciencies Fotòniques, 08860, Barcelona, Spain., Torreno-Pina JA; Center for Genomic Regulation (CRG), Barcelona Institute for Science and Technology (BIST), Barcelona, Spain.; The Barcelona Institute for Science and Technology (BIST), ICFO-Institut de Ciencies Fotòniques, 08860, Barcelona, Spain., Ferrari R; Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, Parma, Italy., Wright RHG; Center for Genomic Regulation (CRG), Barcelona Institute for Science and Technology (BIST), Barcelona, Spain.; Faculty of Medicine and Health Sciences, Universitat Internacional de Catalunya, 08195, Sant Cugat del Vallès, Barcelona, Spain., Garcia-Parajo MF; The Barcelona Institute for Science and Technology (BIST), ICFO-Institut de Ciencies Fotòniques, 08860, Barcelona, Spain.; ICREA, Pg. Lluis Companys 23, 08010, Barcelona, Spain., Joglar J; Department of Biological Chemistry, Institute for Advanced Chemistry of Catalonia, IQAC-CSIC, Jordi Girona 18-26, 08034, Barcelona, Spain., Goñi FM; Instituto Biofisika (UPV/EHU, CSIC), Barrio Sarriena s/n, 48940, Leioa, Spain. felix.goni@ehu.es.; Departamento de Bioquímica y Biología Molecular, Universidad del País Vasco, Barrio Sarriena s/n, 48940, Leioa, Spain. felix.goni@ehu.es., Beato M; Center for Genomic Regulation (CRG), Barcelona Institute for Science and Technology (BIST), Barcelona, Spain. miguel.beato@crg.eu.; Universitat Pompeu Fabra (UPF), Barcelona, Spain. miguel.beato@crg.eu.

Publikováno v: Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2024 Feb 22; Vol. 81 (1), pp. 98. Date of Electronic Publication: 2024 Feb 22.

Signalling network of breast cancer cells in response to progesterone

Autor: Miguel Beato, José Carbonell-Caballero, Wright Rhg, Javier Quilez Oliete, Vastolo

Breast cancer cells enter into the cell cycle following progestin exposure by the activation of signalling cascades involving a plethora of enzymes, transcription factors and co-factors that transmit the external signal from the cell membrane to chro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a779f8526e00055431c34b800e386b1b
http://hdl.handle.net/20.500.12328/3007

Role of the NUDT Enzymes in Breast Cancer.

Autor: Wright RHG; Center for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST), Dr. Aiguader 88, 08003 Barcelona, Spain.; Basic Sciences Department, Faculty of Medicine and Health Sciences, Universitat Internacional de Catalunya, 08003 Barcelona, Spain., Beato M; Center for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST), Dr. Aiguader 88, 08003 Barcelona, Spain.; Department of Life Science, Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2021 Feb 25; Vol. 22 (5). Date of Electronic Publication: 2021 Feb 25.

Identification of potential NUDT5 inhibitors from marine bacterial natural compounds via molecular dynamics and free energy landscape analysis.

Autor: Dubey A; Department of Pharmacology, Saveetha Dental College, and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nādu, 600077, India.; Department of Computational Chemistry and Drug Discovery Division, Quanta Calculus, Greater Noida, 201310, India., Alanazi AM; Pharmaceutical Biotechnology Laboratory, Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia., Bhardwaj R; Department of Chemistry, Poona College, Savitribai Phule Pune University, Pune, India. bhardwajrima08@gmail.com., Ragusa A; Institute of Nanotechnology, CNR-Nanotec, Via Monteroni, 73100, Lecce, Italy. a.ragusa@unilink.it.; Department of Life Sciences, Health and Health Professions, Link Campus University, Via del Casale Di San Pio V 44, 00165, Rome, Italy. a.ragusa@unilink.it.

Publikováno v: Molecular diversity [Mol Divers] 2024 Sep 03. Date of Electronic Publication: 2024 Sep 03.

Author Correction: Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells.

Autor: Page BDG; Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Solna, SE-171 21, Sweden. brent.page@scilifelab.se., Valerie NCK; Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Solna, SE-171 21, Sweden., Wright RHG; Centre de Regulació Genòmica (CRG), Barcelona Institute for Science and Technology, Barcelona, E-09003, Spain.; Universitat Pompeu Fabra, Barcelona, E-08003, Spain., Wallner O; Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Solna, SE-171 21, Sweden., Isaksson R; Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Solna, SE-171 21, Sweden., Carter M; Department of Biochemistry and Biophysics, Stockholm University, Stockholm, SE-106 91, Sweden., Rudd SG; Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Solna, SE-171 21, Sweden., Loseva O; Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Solna, SE-171 21, Sweden., Jemth AS; Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Solna, SE-171 21, Sweden., Almlöf I; Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Solna, SE-171 21, Sweden., Font-Mateu J; Centre de Regulació Genòmica (CRG), Barcelona Institute for Science and Technology, Barcelona, E-09003, Spain.; Universitat Pompeu Fabra, Barcelona, E-08003, Spain., Llona-Minguez S; Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Solna, SE-171 21, Sweden., Baranczewski P; Uppsala University Drug Optimization and Pharmaceutical Profiling Platform, Department of Pharmacy, Uppsala University, Uppsala, SE-751 23, Sweden., Jeppsson F; Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Solna, SE-171 21, Sweden., Homan E; Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Solna, SE-171 21, Sweden., Almqvist H; Chemical Biology Consortium Sweden, Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Solna, SE-171 21, Sweden., Axelsson H; Chemical Biology Consortium Sweden, Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Solna, SE-171 21, Sweden., Regmi S; Chemical Biology Consortium Sweden, Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Solna, SE-171 21, Sweden., Gustavsson AL; Chemical Biology Consortium Sweden, Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Solna, SE-171 21, Sweden., Lundbäck T; Chemical Biology Consortium Sweden, Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Solna, SE-171 21, Sweden., Scobie M; Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Solna, SE-171 21, Sweden., Strömberg K; Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Solna, SE-171 21, Sweden., Stenmark P; Department of Biochemistry and Biophysics, Stockholm University, Stockholm, SE-106 91, Sweden., Beato M; Centre de Regulació Genòmica (CRG), Barcelona Institute for Science and Technology, Barcelona, E-09003, Spain.; Universitat Pompeu Fabra, Barcelona, E-08003, Spain., Helleday T; Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Solna, SE-171 21, Sweden. thomas.helleday@scilifelab.se.

Publikováno v: Nature communications [Nat Commun] 2019 Nov 01; Vol. 10 (1), pp. 5050. Date of Electronic Publication: 2019 Nov 01.