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Significant Impact of Immunogen Design on the Diversity of Antibodies Generated by Carbohydrate-Based Anticancer Vaccine

Autor: Zhaojun Yin, Xuefei Huang, Katarzyna Kaczanowska, Philip Bentley, M. G. Finn, Sudipa Chowdhury, Claire Baniel, W. Shea Wright, Jeffrey C. Gildersleeve, Craig S. McKay, Lbachir BenMohamed

Publikováno v: Yin, Zhaojun; Chowdhury, Sudipa; McKay, Craig; Baniel, Claire; Wright, W. Shea; Bentley, Philip; et al.(2015). Significant Impact of Immunogen Design on the Diversity of Antibodies Generated by Carbohydrate-Based Anticancer Vaccine. ACS Chemical Biology, 10(10), 2364-2372. doi: 10.1021/acschembio.5b00406. UC Irvine: Institute for Clinical and Translational Science. Retrieved from: http://www.escholarship.org/uc/item/8hx3581s
Yin, Zhaojun; Chowdhury, Sudipa; McKay, Craig; Baniel, Claire; Wright, W. Shea; Bentley, Philip; et al.(2015). Significant Impact of Immunogen Design on the Diversity of Antibodies Generated by Carbohydrate-Based Anticancer Vaccine. ACS Chemical Biology, 10(10), 2364-2372. doi: 10.1021/acschembio.5b00406. UC Irvine: Institute for Clinical and Translational Science. Retrieved from: http://www.escholarship.org/uc/item/6sx056fq

Development of an effective vaccine targeting tumor associated carbohydrate antigens (TACAs) is an appealing approach toward tumor immunotherapy. While much emphasis has been typically placed on generating high antibody titers against the immunizing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fa77eb6e229dd267aba699011adf5ba
https://pubmed.ncbi.nlm.nih.gov/26262839