Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Wren Saylor"'
Autor:
Jumana AlHaj Abed, Jelena Erceg, Anton Goloborodko, Son C. Nguyen, Ruth B. McCole, Wren Saylor, Geoffrey Fudenberg, Bryan R. Lajoie, Job Dekker, Leonid A. Mirny, C.-ting Wu
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Trans-homolog interactions, such as homolog pairing, are highly structured and associated with gene function in Drosophila cells. Here, the authors use haplotype-resolved Hi-C to identify genome-wide trans-homolog interactions in a Drosophila hybrid
Externí odkaz:
https://doaj.org/article/efe9374eb24d45d29061d1cd4af22228
Autor:
Jelena Erceg, Jumana AlHaj Abed, Anton Goloborodko, Bryan R. Lajoie, Geoffrey Fudenberg, Nezar Abdennur, Maxim Imakaev, Ruth B. McCole, Son C. Nguyen, Wren Saylor, Eric F. Joyce, T. Niroshini Senaratne, Mohammed A. Hannan, Guy Nir, Job Dekker, Leonid A. Mirny, C.-ting Wu
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Homologs are paired in Drosophila somatic cells from embryogenesis to adulthood. Using a computational approach for haplotype-resolved Hi-C, the authors reveal highly structured homolog pairing in Drosophila embryos during zygotic genome activation a
Externí odkaz:
https://doaj.org/article/93745053c3604cd7b79badd5961d288d
Publikováno v:
Cell Reports, Vol 24, Iss 2, Pp 479-488 (2018)
Summary: This study explores the relationship between three-dimensional genome organization and ultraconserved elements (UCEs), an enigmatic set of DNA elements that are perfectly conserved between the reference genomes of distantly related species.
Externí odkaz:
https://doaj.org/article/6f173673f1a743eaa03a2fa99b36f7f0
Autor:
Matthew Dysart, Kathleen Leeper, Marc Vidal, Richie E. Kohman, Seth L. Shipman, Jussi Taipale, Juan M. Melero-Martin, Andyna Vernet, Wren Saylor, Giovanni Pasquini, Kiavash Kiaee, Parastoo Khoshakhlagh, Jesus Eduardo Rojo Arias, Anka Swiersy, George M. Church, Alex Hay-Man Ng, Jeremy Y. Huang, Kai Wang, Volker Busskamp, Evan Appleton, Amanda R. Graveline, David E. Hill
Publikováno v:
Nature Biotechnology
Nature biotechnology
Nature biotechnology
Human pluripotent stem cells (hPSCs) offer an unprecedented opportunity to model diverse cell types and tissues. To enable systematic exploration of the programming landscape mediated by transcription factors (TFs), we present the Human TFome, a comp
Autor:
Ruth B. McCole, Geoffrey Fudenberg, Leonid A. Mirny, Anton Goloborodko, Jumana AlHaj Abed, Jelena Erceg, Wren Saylor, C.-ting Wu, Job Dekker, Son C. Nguyen, Bryan R. Lajoie
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications
Nature Communications
Trans-homolog interactions have been studied extensively in Drosophila, where homologs are paired in somatic cells and transvection is prevalent. Nevertheless, the detailed structure of pairing and its functional impact have not been thoroughly inves
Autor:
Zun Zar Chi Naing, Maru Jaime-Garza, Taia S. Wu, Laurel S Estes, Martin Kampmann, Eric D. Chow, Taylor B. Cavazos, Miriam A. Goldman, Yessica K. Gomez, William F. DeGrado, Stephanie A. Wankowicz, Matthew C. Johnson, Christa Caggiano, Christina A. Stephens, Bryan Faust, Daniel Barrero, Lakshmi E. Miller-Vedam, Elizabeth E. McCarthy, Kyle E. Lopez, Sy Redding, Jenna Pellegrino, Elissa A Fink, Wren Saylor, Alison M Maxwell, Hayarpi Torosyan, Jared Lumpe, Robert W. Newberry, George C. Hartoularos, Daniel M. C. Schwarz, Calla Martyn, Laura M. Gunsalus, Jack Strickland, Maureen Pittman, Taylor Arhar, Andrew F. Kung, Daniel R. Wong, Garrett Wong, Nishith R. Reddy, Matthew G. Jones, Aji Palar, Erik J. Navarro, Nick Hoppe, M. Grace Gordon, Douglas R. Wassarman, Jean Costello, Adam Catching
Publikováno v:
ACS Chem Biol
ACS chemical biology, vol 15, iss 8
ACS chemical biology, vol 15, iss 8
Protein conformations are shaped by cellular environments, but how environmental changes alter the conformational landscapes of specific proteins in vivo remains largely uncharacterized, in part due to the challenge of probing protein structures in l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8292e5bf8e0f1174d79b4faba3fc334b
Autor:
Bryan R. Lajoie, C.-ting Wu, Ruth B. McCole, Wren Saylor, Geoffrey Fudenberg, Maxim Imakaev, Eric F. Joyce, Guy Nir, Job Dekker, Mohammed A. Hannan, T. Niroshini Senaratne, Jumana AlHaj Abed, Anton Goloborodko, Son C. Nguyen, Jelena Erceg, Leonid A. Mirny, Nezar Abdennur
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Nature Communications
Nature Communications
Genome organization involves cis and trans chromosomal interactions, both implicated in gene regulation, development, and disease. Here, we focus on trans interactions in Drosophila, where homologous chromosomes are paired in somatic cells from embry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40a762ee4cbbc375f90cc581dfaf6f76
https://doi.org/10.1101/443028
https://doi.org/10.1101/443028
Publikováno v:
Cell Reports, Vol 24, Iss 2, Pp 479-488 (2018)
Summary: This study explores the relationship between three-dimensional genome organization and ultraconserved elements (UCEs), an enigmatic set of DNA elements that are perfectly conserved between the reference genomes of distantly related species.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d92416343affa7335747c4c2ba6c59fb
https://doi.org/10.1101/235242
https://doi.org/10.1101/235242
Autor:
C.-ting Wu, Jelena Erceg, Claire Redin, Chamith Y. Fonseka, Ruth B. McCole, Michael E. Talkowski, Harrison Brand, Wren Saylor
The development of the human brain and nervous system can be affected by genetic or environmental factors. Here we focus on characterizing the genetic perturbations that accompany and may contribute to neurodevelopmental phenotypes. Specifically, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc7a954c388eb56ba7999c03f6920283
https://doi.org/10.1101/233197
https://doi.org/10.1101/233197