Nucleus accumbens dopamine tracks aversive stimulus duration and prediction but not value or prediction error

Autor: Jessica N Goedhoop, Bastijn JG van den Boom, Rhiannon Robke, Felice Veen, Lizz Fellinger, Wouter van Elzelingen, Tara Arbab, Ingo Willuhn

Publikováno v: eLife, Vol 11 (2022)

There is active debate on the role of dopamine in processing aversive stimuli, where inferred roles range from no involvement at all, to signaling an aversive prediction error (APE). Here, we systematically investigate dopamine release in the nucleus

Externí odkaz: https://doaj.org/article/47ed9246e4404ed3892855fa0086f847

A unidirectional but not uniform striatal landscape of dopamine signaling for motivational stimuli

Autor: Wouter van Elzelingen, Jessica Goedhoop, Pascal Warnaar, Damiaan Denys, Tara Arbab, Ingo Willuhn

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 119(21). National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America, 119(21):e2117270119. National Academy of Sciences

Dopamine signals in the striatum are critical for motivated behavior. However, their regional specificity and precise information content are actively debated. Dopaminergic projections to the striatum are topographically organized. Thus, we quantifie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8231d8e8d942d44f530b0560109b53d
https://pure.knaw.nl/portal/en/publications/54c82385-cf74-412b-a7ac-3bc46a6bf341

Influence of Sex Hormones on OCD

Autor: Valeria Guglielmi, Judith Souget, Wouter van Elzelingen, Ingo Willuhn, Nienke Vulink

OCD symptoms often seem to correlate with hormonal changes. For example, onset during puberty or in the postpartum period is common, and some female patients report monthly fluctuations in their symptoms. This chapter reviews available evidence about

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8a95c6827e1b0ebd8f6e8edbd14012c9
https://doi.org/10.1093/med/9780190228163.003.0027

Obsessive-compulsive Disorder : Phenomenology, Pathophysiology, and Treatment

Autor: Christopher Pittenger

Obsessive-compulsive disorder affects approximately one person in 40 and causes great suffering. Effective treatments are available that can help many, and our understanding of the psychology, neurobiology, and clinical treatment of the disorder has