Label-free LC-MSe in tissue and serum reveals protein networks underlying differences between benign and malignant serous ovarian tumors.

Autor: Wouter Wegdam, Carmen A Argmann, Gertjan Kramer, Johannes P Vissers, Marrije R Buist, Gemma G Kenter, Johannes M F G Aerts, Danielle Meijer, Perry D Moerland

Publikováno v: PLoS ONE, Vol 9, Iss 9, p e108046 (2014)

PurposeTo identify proteins and (molecular/biological) pathways associated with differences between benign and malignant epithelial ovarian tumors.Experimental proceduresSerum of six patients with a serous adenocarcinoma of the ovary was collected be

Externí odkaz: https://doaj.org/article/034990b2eb1c49cca4433dc419d364d4

Elevation of glycoprotein nonmetastatic melanoma protein B in type 1 Gaucher disease patients and mouse models

Autor: Johannes M. F. G. Aerts, Marri Verhoek, Timothy M. Cox, Elena Pavlova, Wilma E. Donker-Koopman, Rolf G. Boot, Jessica K. Nelson, Gert Jan Kramer, Wouter W. Kallemeijn, Mary Teresa Moran, Wouter Wegdam, Roelof Ottenhoff, Jon D. Laman, Marco van Eijk, Paulo Gaspar, Tanit L. Gabriel, Johannes P. C. Vissers

Publikováno v: FEBS Open Bio
FEBS Open Bio, 6(9), 902-913. Wiley-Blackwell
FEBS Open Bio, 6(9), 902-913. Wiley Open Access
FEBS open bio, 6(9), 902-913. Wiley-Blackwell

Gaucher disease is caused by inherited deficiency of lysosomal glucocerebrosidase. Proteome analysis of laser-dissected splenic Gaucher cells revealed increased amounts of glycoprotein nonmetastatic melanoma protein B (gpNMB). Plasma gpNMB was also e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9904b801f366cbc06c3d1033778f123c
https://www.repository.cam.ac.uk/handle/1810/289591

Label-Free LC-MSe in Tissue and Serum Reveals Protein Networks Underlying Differences between Benign and Malignant Serous Ovarian Tumors

Autor: Johannes P. C. Vissers, Danielle Meijer, Wouter Wegdam, Johannes M. F. G. Aerts, Marrije R. Buist, Carmen Argmann, Perry D. Moerland, Gert Jan Kramer, Gemma G. Kenter

Publikováno v: PLoS ONE
PLoS ONE, Vol 9, Iss 9, p e108046 (2014)
PLoS ONE, 9(9), e108046-(12 p.). Public Library of Science

PurposeTo identify proteins and (molecular/biological) pathways associated with differences between benign and malignant epithelial ovarian tumors.Experimental proceduresSerum of six patients with a serous adenocarcinoma of the ovary was collected be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e80f20cec5ab9b93c179fd6c71a5ea39
http://europepmc.org/articles/PMC4180266

Gaucher disease: a model disorder for biomarker discovery

Autor: Wouter Wegdam, Johannes M. F. G. Aerts, Laura van Dussen, Richard R. Sprenger, Mariëlle J. van Breemen, Shreyas M. de Jong, Dave Speijer, Johannes P. C. Vissers, Huub C. J. Hoefsloot, Age K. Smilde, Carla E. M. Hollak, Chris G. de Koster, Rolf G. Boot

Publikováno v: Expert Review of Proteomics, 6(4), 411-419. Taylor and Francis Ltd.
Boot, R G, van Breemen, M J, Wegdam, W, Sprenger, R R, de Jong, S, Speijer, D, Hollak, C E M, van Dussen, L, Hoefsloot, H C J, Smilde, A K, de Koster, C G, Vissers, J P C & Aerts, J M F G 2009, ' Gaucher disease: a model disorder for biomarker discovery ', Expert Review of Proteomics, vol. 6, no. 4, pp. 411-9 . https://doi.org/10.1586/epr.09.54

Udgivelsesdato: 2009-Aug Gaucher disease is an inherited lysosomal storage disorder, characterized by massive accumulation of glucosylceramide-laden macrophages in the spleen, liver and bone marrow as a consequence of deficient activity of glucocereb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c42270743e701d9db5b35967f557985
https://dare.uva.nl/personal/pure/en/publications/gaucher-disease-a-model-disorder-for-biomarker-discovery(1a25f337-7f9e-4b84-b6c6-5fb22f398a44).html

Abstract 4800: Quantitative detection of discriminatory proteins in tissue and serum of ovarian cancer patients by LC-MSE

Autor: Hans Aerts, Johannes P. C. Vissers, Wouter Wegdam, Perry D. Moerland, Danielle Meijer, James I. Langridge, Shreyas M. de Jong, Marrije R. Buist, Gemma G. Kenter, Gert Jan Kramer

Publikováno v: Cancer Research. 72:4800-4800

Purpose: Using label-free UPLC-MSE quantification methods to identifying proteins as well as determining their abundance in serum and microdissected ovarian cancer tissue. Experimental procedures: Serum of six patients with a serous adenocarcinoma of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::671be1e1d1e20c85d3c8df440acedd20
https://doi.org/10.1158/1538-7445.am2012-4800