Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Wouter W, Wiegant"'
Autor:
Bert van de Kooij, Fenna J. van der Wal, Magdalena B. Rother, Wouter W. Wiegant, Pau Creixell, Merula Stout, Brian A. Joughin, Julia Vornberger, Matthias Altmeyer, Marcel A. T. M. van Vugt, Michael B. Yaffe, Haico van Attikum
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract During the repair of interstrand crosslinks (ICLs) a DNA double-strand break (DSB) is generated. The Fanconi anemia (FA) core complex, which is recruited to ICLs, promotes high-fidelity repair of this DSB by homologous recombination (HR). Ho
Externí odkaz:
https://doaj.org/article/8089b7910a9a4e0b88480d0ad31ef39a
Autor:
Jenny Kaur Singh, Rebecca Smith, Magdalena B. Rother, Anton J. L. de Groot, Wouter W. Wiegant, Kees Vreeken, Ostiane D’Augustin, Robbert Q. Kim, Haibin Qian, Przemek M. Krawczyk, Román González-Prieto, Alfred C. O. Vertegaal, Meindert Lamers, Sébastien Huet, Haico van Attikum
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-21 (2021)
Classical non-homologous end-joining (cNHEJ) is the dominant pathway used by human cells to repair DNA double-strand breaks (DSBs) and maintain genome stability. Here the authors show that PARP1-driven chromatin expansion allows the recruitment of ZN
Externí odkaz:
https://doaj.org/article/81eb6422ad4941fe875820f223a85fd7
Autor:
Magdalena B. Rother, Stefania Pellegrino, Rebecca Smith, Marco Gatti, Cornelia Meisenberg, Wouter W. Wiegant, Martijn S. Luijsterburg, Ralph Imhof, Jessica A. Downs, Alfred C. O. Vertegaal, Sébastien Huet, Matthias Altmeyer, Haico van Attikum
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
Chromatin is dynamically remodeled in response to DNA damage in favour of repair. Here the authors reveal how the chromatin remodeler CHD7 and chromatin binding protein 53BP1 regulate distinct DNA repair pathways.
Externí odkaz:
https://doaj.org/article/297076b4803a47eba7a1ecb7f931f8c7
Autor:
Rick A. C. M. Boonen, Amélie Rodrigue, Chantal Stoepker, Wouter W. Wiegant, Bas Vroling, Milan Sharma, Magdalena B. Rother, Nandi Celosse, Maaike P. G. Vreeswijk, Fergus Couch, Jacques Simard, Peter Devilee, Jean-Yves Masson, Haico van Attikum
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
PALB2 is an established breast cancer risk gene but the pathogenicity of many variants remains uncharacterised. Here, the authors present a cDNA-based system for the functional analysis of PALB2 variants of unknown significance.
Externí odkaz:
https://doaj.org/article/1494cb25245145e3baee045ab9de1c81
Autor:
Georgia Velimezi, Lydia Robinson-Garcia, Francisco Muñoz-Martínez, Wouter W. Wiegant, Joana Ferreira da Silva, Michel Owusu, Martin Moder, Marc Wiedner, Sara Brin Rosenthal, Kathleen M. Fisch, Jason Moffat, Jörg Menche, Haico van Attikum, Stephen P. Jackson, Joanna I. Loizou
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Fanconi anemia is a rare disease caused by defective DNA interstrand crosslink repair. Here the authors observe that USP48 deficiencies reduce chromosomal instability in FA-defective cells, suggesting it might be a potential therapeutic target.
Externí odkaz:
https://doaj.org/article/92ba886efa2648b7b1f7f3b80505b1ec
Autor:
Haico van Attikum, Giancarlo Marra, Maaike P.G. Vreeswijk, Peter Devilee, Rosalind Eeles, Niko Beerenwinkel, Tom van Wezel, Nienke Solleveld-Westerink, Simona Cristea, Martina Mijuskovic, Zsofia Kote-Jarai, Stephan Heijl, Bas Vroling, Nandi Celosse, Wouter W. Wiegant, Rick A.C.M. Boonen
Supplementary Data from Functional Analysis Identifies Damaging CHEK2 Missense Variants Associated with Increased Cancer Risk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9380cd14597f78e3ef435076343ee0d6
https://doi.org/10.1158/0008-5472.22431525
https://doi.org/10.1158/0008-5472.22431525
Autor:
Haico van Attikum, Giancarlo Marra, Maaike P.G. Vreeswijk, Peter Devilee, Rosalind Eeles, Niko Beerenwinkel, Tom van Wezel, Nienke Solleveld-Westerink, Simona Cristea, Martina Mijuskovic, Zsofia Kote-Jarai, Stephan Heijl, Bas Vroling, Nandi Celosse, Wouter W. Wiegant, Rick A.C.M. Boonen
Supplementary Table from Functional Analysis Identifies Damaging CHEK2 Missense Variants Associated with Increased Cancer Risk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0774df428d026548e2c03e673528fcf2
https://doi.org/10.1158/0008-5472.22431522
https://doi.org/10.1158/0008-5472.22431522
Autor:
Haico van Attikum, Giancarlo Marra, Maaike P.G. Vreeswijk, Peter Devilee, Rosalind Eeles, Niko Beerenwinkel, Tom van Wezel, Nienke Solleveld-Westerink, Simona Cristea, Martina Mijuskovic, Zsofia Kote-Jarai, Stephan Heijl, Bas Vroling, Nandi Celosse, Wouter W. Wiegant, Rick A.C.M. Boonen
Heterozygous carriers of germline loss-of-function variants in the tumor suppressor gene checkpoint kinase 2 (CHEK2) are at an increased risk for developing breast and other cancers. While truncating variants in CHEK2 are known to be pathogenic, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::665d875a87a2881c3ff345345625c377
https://doi.org/10.1158/0008-5472.c.6513927.v1
https://doi.org/10.1158/0008-5472.c.6513927.v1
Autor:
Cornelia G. Spruijt, Martijn S. Luijsterburg, Roberta Menafra, Rik G.H. Lindeboom, Pascal W.T.C. Jansen, Raghu Ram Edupuganti, Marijke P. Baltissen, Wouter W. Wiegant, Moritz C. Voelker-Albert, Filomena Matarese, Anneloes Mensinga, Ina Poser, Harmjan R. Vos, Hendrik G. Stunnenberg, Haico van Attikum, Michiel Vermeulen
Publikováno v:
Cell Reports, Vol 17, Iss 3, Pp 783-798 (2016)
NuRD (nucleosome remodeling and histone deacetylase) is a versatile multi-protein complex with roles in transcription regulation and the DNA damage response. Here, we show that ZMYND8 bridges NuRD to a number of putative DNA-binding zinc finger prote
Externí odkaz:
https://doaj.org/article/6b11b3bcc77141fe971247c6642be1e9
Autor:
Martijn S Luijsterburg, Dimitris Typas, Marie-Christine Caron, Wouter W Wiegant, Diana van den Heuvel, Rick A Boonen, Anthony M Couturier, Leon H Mullenders, Jean-Yves Masson, Haico van Attikum
Publikováno v:
eLife, Vol 6 (2017)
DNA double-strand breaks (DSB) elicit a ubiquitylation cascade that controls DNA repair pathway choice. This cascade involves the ubiquitylation of histone H2A by the RNF168 ligase and the subsequent recruitment of RIF1, which suppresses homologous r
Externí odkaz:
https://doaj.org/article/8ceed8f982b241459d4fdb5dea866975