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pro vyhledávání: '"Wouter Tonnis"'
Autor:
Shan Wang, Peter Serno, Wouter Tonnis, Huijun Chen, Feng Qian, Linc Chen, Yipshu Pui, Yuejie Chen
Publikováno v:
Molecular Pharmaceutics. 16:205-213
We investigated the drug-polymer interactions in nonaqueous and aqueous environments between a poorly water-soluble drug, BAY1161909 (909), and two commonly used polymers in amorphous solid dispersions, i.e., PVP and HPMC-AS. In an nonaqueous state,
Autor:
Huijun Chen, Wouter Tonnis, Linc Chen, Shan Wang, Peter Serno, Stefan Bracht, Feng Qian, Chengyu Liu, Yipshu Pui, Yuejie Chen
Publikováno v:
Molecular Pharmaceutics. 15:2754-2763
Amorphous solid dispersion (ASD) is one of the most versatile supersaturating drug delivery systems to improve the dissolution rate and oral bioavailability of poorly water-soluble drugs. PVP based ASD formulation of nimodipine (NMD) has been markete