Zobrazeno 1 - 10 of 33 pro vyhledávání: '"Wouter L Smit"'
1
Akademický článek
Intestinal Apc‐inactivation induces HSP25 dependency
Autor: Sanne M van Neerven, Wouter L Smit, Milou S van Driel, Vaishali Kakkar, Nina E de Groot, Lisanne E Nijman, Clara C Elbers, Nicolas Léveillé, Jarom Heijmans, Louis Vermeulen
Publikováno v: EMBO Molecular Medicine, Vol 14, Iss 12, Pp 1-16 (2022)
Abstract The majority of colorectal cancers (CRCs) present with early mutations in tumor suppressor gene APC. APC mutations result in oncogenic activation of the Wnt pathway, which is associated with hyperproliferation, cytoskeletal remodeling, and a
Externí odkaz: https://doaj.org/article/891ee3363d044458ba63925b9b465371
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2
Akademický článek
Endoplasmic reticulum stress regulates the intestinal stem cell state through CtBP2
Autor: Bartolomeus J. Meijer, Wouter L. Smit, Pim J. Koelink, Barbara F. Westendorp, Ruben J. de Boer, Jonathan H. M. van der Meer, Jacqueline L. M. Vermeulen, James C. Paton, Adrienne W. Paton, Jun Qin, Evelien Dekker, Vanesa Muncan, Gijs R. van den Brink, Jarom Heijmans
Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Enforcing differentiation of cancer stem cells is considered as a potential strategy to sensitize colorectal cancer cells to irradiation and chemotherapy. Activation of the unfolded protein response, due to endoplasmic reticulum (ER) stress,
Externí odkaz: https://doaj.org/article/24ebfc27c3394013a484ca3d122122e9
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3
Akademický článek
Heterologous Immune Responses of Serum IgG and Secretory IgA Against the Spike Protein of Endemic Coronaviruses During Severe COVID-19
Autor: Wouter L. Smit, Sophie van Tol, Sanne van der Wal, Femke van Vulpen, Shannon la Grouw, Lenneke van Lelyveld, Gijs Limonard, Ailko Bossink, Gert-Jan Godeke, Sandhya Shrestha, Johan Reimerink, Dirk Eggink, Chantal Reusken, Michiel Heron, Steven Thijsen
Publikováno v: Frontiers in Immunology, Vol 13 (2022)
Defining immune correlates of disease severity is important to better understand the immunopathogenesis in COVID-19. Here we made use of a protein microarray platform to detect IgG- and IgA-reactive antibodies in sera and saliva respectively, and ass
Externí odkaz: https://doaj.org/article/56c6023616cd4ffdb9c836ce5a805f9e
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8
Early Life Antibiotics Influence In Vivo and In Vitro Mouse Intestinal Epithelium Maturation and FunctioningSummary
Autor: Jan Koster, Pim J. Koelink, Manon van Roest, Sander Meisner, Ingrid B. Renes, William J. Faller, Joana Silva, Wouter L. Smit, Jacqueline L.M. Vermeulen, Manon E. Wildenberg, Vanesa Muncan, Ruurd M. van Elburg, Tânia Martins Garcia
Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 3, Pp 943-981 (2021)
Cellular and Molecular Gastroenterology and Hepatology
Cellular and molecular gastroenterology and hepatology, 12(3), 943-981. Elsevier Inc.
Background & Aims The use of antibiotics (ABs) is a common practice during the first months of life. ABs can perturb the intestinal microbiota, indirectly influencing the intestinal epithelial cells (IECs), but can also directly affect IECs independe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c861cf76325ee471195673d49383545
http://www.sciencedirect.com/science/article/pii/S2352345X21001132
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9
Endoplasmic reticulum stress regulates the intestinal stem cell state through CtBP2
Autor: Pim J. Koelink, James C. Paton, Jonathan H. M. van der Meer, Wouter L. Smit, Gijs R. van den Brink, Ruben J. de Boer, Bartolomeus J. Meijer, Adrienne W. Paton, Jarom Heijmans, Jacqueline L.M. Vermeulen, Vanesa Muncan, Barbara F. Westendorp, Jun Qin, Evelien Dekker
Publikováno v: Scientific reports, 11(1):9892. Nature Publishing Group
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Scientific Reports
Enforcing differentiation of cancer stem cells is considered as a potential strategy to sensitize colorectal cancer cells to irradiation and chemotherapy. Activation of the unfolded protein response, due to endoplasmic reticulum (ER) stress, causes r
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::224046a787934079d32021515ba0fffd
http://www.scopus.com/inward/record.url?scp=85105583312&partnerID=8YFLogxK
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10
The concerted action of oncogenic driver mutations directs global translation in intestinal epithelial cells
Autor: Jarom Heijmans, Wouter L. Smit
Publikováno v: Mol Cell Oncol
Molecular & cellular oncology, 8(4):1879614. Taylor and Francis Ltd.
Oncogenic transformation of colorectal cancer cells is driven by a set of mutations that cause aberrant signaling of growth factor–receptor pathways. Using organoids, we demonstrate that the most frequent driver mutations in APC, KRAS, SMAD4, and T
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8194db6dbc28c579cbb0459b38a72ff4
https://pubmed.ncbi.nlm.nih.gov/34616863
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