Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Wouter Korver"'
Autor:
Julia Schanin, Wouter Korver, Emily C. Brock, John Leung, Zachary Benet, Thuy Luu, Katherine Chang, Alan Xu, Naomi De Freitas, Kenneth Luehrsen, Michael A. Brehm, Alan Wong, Bradford A. Youngblood
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-13 (2022)
An agonistic Siglec-6 antibody that binds to a membrane-distal domain of Siglec-6 is identified that induces inhibition and reduction of mast cells and suppresses anaphylaxis in a humanized mouse model.
Externí odkaz:
https://doaj.org/article/8555549fd31544c7aa8404b25f5252f9
Autor:
Wouter Korver, Alan Wong, Simon Gebremeskel, Gian Luca Negri, Julia Schanin, Katherine Chang, John Leung, Zachary Benet, Thuy Luu, Emily C. Brock, Kenneth Luehrsen, Alan Xu, Bradford A. Youngblood
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Immunomodulation of mast cell (MC) activity is warranted in allergic and inflammatory diseases where MCs have a central role in pathogenesis. Targeting Siglec-8, an inhibitory receptor on MCs and eosinophils, has shown promising activity in preclinic
Externí odkaz:
https://doaj.org/article/fc996b1aedce4815b6a0eb6f4573d07f
Autor:
Simon Gebremeskel, Julia Schanin, Krysta M. Coyle, Melina Butuci, Thuy Luu, Emily C. Brock, Alan Xu, Alan Wong, John Leung, Wouter Korver, Ryan D. Morin, Robert P. Schleimer, Bruce S. Bochner, Bradford A. Youngblood
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 infection represents a global health crisis. Immune cell activation via pattern recognition receptors has been implicated as a driver of the hyperinflammatory response seen in COVID-19. However
Externí odkaz:
https://doaj.org/article/6c36a84cb2e642e38ca9f2806e606704
Autor:
Piper A. Robida, Clayton H. Rische, Netali Ben-Baruch Morgenstern, Rethavathi Janarthanam, Yun Cao, Rebecca A. Krier-Burris, Wouter Korver, Alan Xu, Thuy Luu, Julia Schanin, John Leung, Marc E. Rothenberg, Joshua B. Wechsler, Bradford A. Youngblood, Bruce S. Bochner, Jeremy A. O’Sullivan
Publikováno v:
Cells, Vol 11, Iss 7, p 1138 (2022)
Mast cells are tissue-resident cells that contribute to allergic diseases, among others, due to excessive or inappropriate cellular activation and degranulation. Therapeutic approaches to modulate mast cell activation are urgently needed. Siglec-6 is
Externí odkaz:
https://doaj.org/article/aa4a409462d94394aa31a086eef4afb4
Autor:
Xiaoxian Zhao, Shweta Singh, Cecile Pardoux, Jingsong Zhao, Eric D. Hsi, Arie Abo, Wouter Korver
Publikováno v:
Haematologica, Vol 95, Iss 1 (2010)
Background C-type lectin-like molecule-1 is a transmembrane receptor expressed on myeloid cells, acute myeloid leukemia blasts and leukemic stem cells. To validate the potential of this receptor as a therapeutic target in acute myeloid leukemia, we g
Externí odkaz:
https://doaj.org/article/52b9ee8f6f09436cb0587ec224e90bd9
Autor:
Julia Schanin, Thuy Luu, Robert Sanchez, Milene Peterson, Lisa McEwan, Evan Henneberry, Katherine Chang, Wouter Korver, John Leung, Bradford Youngblood
Publikováno v:
Regular and Young Investigator Award Abstracts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95a47021cde297258822f85c06b8d2d5
https://doi.org/10.1136/jitc-2022-sitc2022.1396
https://doi.org/10.1136/jitc-2022-sitc2022.1396
Autor:
Krysta M. Coyle, Wouter Korver, Ryan D. Morin, Bradford A. Youngblood, Alan Wong, Simon Gebremeskel, Alan Xu, Emily C. Brock, Thuy U. Luu, Robert P. Schleimer, Melina Butuci, Bruce S. Bochner, Julia Schanin, John Leung
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology
Frontiers in Immunology
Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 infection represents a global health crisis. Immune cell activation via pattern recognition receptors has been implicated as a driver of the hyperinflammatory response seen in COVID-19. However
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76f412d963026c6c02b47a2641d6470c
https://www.frontiersin.org/articles/10.3389/fimmu.2021.650331/full
https://www.frontiersin.org/articles/10.3389/fimmu.2021.650331/full
Autor:
Glennda Smithson, Jonathan Zalevsky, Cindy Q. Xia, Mary Carsillo, Neeraja Idamakanti, Pu Shi, Josh Yuan, Wouter Korver, Matthew Wagoner, Eric R. Fedyk, Lachy McLean
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 370(2)
Ectoenzyme CD38 is increased on lymphocytes in response to an antigenic challenge and it9s hypothesized that targeting these activated lymphocytes could ameliorate pathologic activities in autoimmune diseases. The cynomolgus monkey is an appropriate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c3f0b56a867c281f2844a5dd64685df
https://pubmed.ncbi.nlm.nih.gov/31085699
https://pubmed.ncbi.nlm.nih.gov/31085699
Autor:
Aaron Winkler, Katherine L. Lee, Wouter Korver, Rachael Hawtin, Lih-Ling Lin, Margaret Fleming, Vikram R. Rao, Scott A. Jelinsky, Leah Cushing
Interleukin-1 receptor–associated kinase 4 (IRAK4) plays a critical role in innate immune signaling by Toll-like receptors (TLRs), and loss of IRAK4 activity in mice and humans increases susceptibility to bacterial infections and causes defects in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ee786653c024ba05a487d084b0ba283
https://europepmc.org/articles/PMC5682975/
https://europepmc.org/articles/PMC5682975/
Autor:
Jingsong Zhao, Arie Abo, Wouter Korver, Xiaoxian Zhao, Cécile Pardoux, Shweta Singh, Eric D. Hsi
Publikováno v:
Haematologica. 95:71-78
Background C-type lectin-like molecule-1 is a transmembrane receptor expressed on myeloid cells, acute myeloid leukemia blasts and leukemic stem cells. To validate the potential of this receptor as a therapeutic target in acute myeloid leukemia, we g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f976485af06ad985ca69eea29ee15e37
https://doi.org/10.3324/haematol.2009.009811
https://doi.org/10.3324/haematol.2009.009811