An automated screening method for detecting compounds with goitrogenic activity using transgenic zebrafish embryos.

Autor: Sergio Jarque, Eva Fetter, Wouter J Veneman, Herman P Spaink, Ravindra Peravali, Uwe Strähle, Stefan Scholz

Publikováno v: PLoS ONE, Vol 13, Iss 8, p e0203087 (2018)

The knowledge on environmentally relevant chemicals that may interfere with thyroid signaling is scarce. Here, we present a method for the screening of goitrogens, compounds that disrupt the thyroid gland function, based on the automatic orientation

Externí odkaz: https://doaj.org/article/27315ee32f7b4101bc3bd26d5fdfc2ca

A high-throughput screen for tuberculosis progression.

Autor: Ralph Carvalho, Jan de Sonneville, Oliver W Stockhammer, Nigel D L Savage, Wouter J Veneman, Tom H M Ottenhoff, Ron P Dirks, Annemarie H Meijer, Herman P Spaink

Publikováno v: PLoS ONE, Vol 6, Iss 2, p e16779 (2011)

One-third of the world population is infected with Mycobacterium tuberculosis and multi-drug resistant strains are rapidly evolving. The noticeable absence of a whole organism high-throughput screening system for studying the progression of tuberculo

Externí odkaz: https://doaj.org/article/f48d3188535341409455dd502ae3be14

Pathway analysis of systemic transcriptome responses to injected polystyrene particles in zebrafish larvae

Autor: Thijs Bosker, Nadja R. Brun, Wouter J. Veneman, Herman P. Spaink, Martina G. Vijver

Publikováno v: Aquatic Toxicology
Aquatic Toxicology, 190, 112-120

Microplastics are a contaminant of emergent concern in the environment, however, to date there is a limited understanding on their movement within organisms and the response of organisms. In the current study zebrafish embryos at different developmen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28dc1c6f55810bd18f493f846235427b
https://doi.org/10.1016/j.aquatox.2017.06.014

Robotic injection of zebrafish embryos for high-throughput screening in disease models

Autor: Wouter J. Veneman, Wietske van der Ent, B. Ewa Snaar-Jagalska, William P.J. Leenders, Herman P. Spaink, Annemarie H. Meijer, Hans J. Jansen, Chao Cui, Ron P. Dirks, Malgorzata Wiweger, Jan de Sonneville, Rubén Marín-Juez, Anita Ordas, Vincenzo Torraca

Publikováno v: Methods; Vol 62
Methods, 62(3), 246-254
Methods: a Journal for Human Science, 62, 3, pp. 246-54
Methods
Methods: a Journal for Human Science, 62, 246-54

Item does not contain fulltext The increasing use of zebrafish larvae for biomedical research applications is resulting in versatile models for a variety of human diseases. These models exploit the optical transparency of zebrafish larvae and the ava

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26f069df2b415047ff1c7833335f14d3

Automation of Technology for Cancer Research

Autor: Wietske, van der Ent, Wouter J, Veneman, Arwin, Groenewoud, Lanpeng, Chen, Claudia, Tulotta, Pancras C W, Hogendoorn, Herman P, Spaink, B Ewa, Snaar-Jagalska

Publikováno v: Advances in experimental medicine and biology. 916

Zebrafish embryos can be obtained for research purposes in large numbers at low cost and embryos develop externally in limited space, making them highly suitable for high-throughput cancer studies and drug screens. Non-invasive live imaging of variou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f91f756b8a68e1d765226fc0fb2483a1
https://pubmed.ncbi.nlm.nih.gov/27165360