Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Wouter I, Iwema Bakker"'
Autor:
Josephus H. M. Lange, Remco Henzen, Natasja de Bruin, Jelle de Vries, Wouter I. Iwema Bakker, Wouter de Looff, Arnold P. den Hartog, Stefan Verhoog, Rob P. van de Woestijne, Chris G. Kruse, Arnold van Loevezijn, Jennifer Venhorst, Martina A.W. van der Neut
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:1605-1611
The discovery of non-basic N'-(arylsulfonyl)pyrazoline-1-carboxamidines as 5-HT6 antagonists with unique structural features was recently disclosed. Here we describe how this structural class was further developed by addressing an unexplored interact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cf6abbf2099e90ec1e67445cecda377
https://doi.org/10.1016/j.bmcl.2016.02.001
https://doi.org/10.1016/j.bmcl.2016.02.001
Autor:
Cor G de Korte, Stefan Verhoog, Martina A.W. van der Neut, Wouter I. Iwema Bakker, Alice J.M. Borst, Jennifer Venhorst, Chris G. Kruse, Natasja de Bruin, Rob P. van de Woestijne, Hiskias G. Keizer, Arnold van Loevezijn, Wouter de Looff, Jan-Willem van Wees, Maria J.P. van Dongen, Martijn van Hoeve
Publikováno v:
Journal of Medicinal Chemistry. 54:7030-7054
The 5-HT(6) receptor (5-HT(6)R) has been in the spotlight for several years regarding CNS-related diseases. We set out to discover novel, neutral 5-HT(6)R antagonists to improve off-target selectivity compared to basic amine-containing scaffolds domi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::01b80e49fd141f75bc4e9afb4ff68b46
https://doi.org/10.1021/jm200466r
https://doi.org/10.1021/jm200466r
Autor:
Herman J. den Hertog, M Haas, Dick de Zeeuw, Willem Verboom, Wouter I. Iwema Bakker, David N. Reinhoudt
Publikováno v:
Journal of the Chemical Society. Perkin transactions II, 1994(1), 11-14. Chemical Society
A general method has been developed for the determination of kinetic stabilities of macrocyclic alkali-metal complexes with rates of decomplexation (Kd) below 10-3 s-1, by use of radioactive isotopes. This method offers the possibility to study the i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c417be4ed45e24c6e2a4096321943545
https://doi.org/10.1039/p29940000011
https://doi.org/10.1039/p29940000011
Autor:
Arnold, van Loevezijn, Jennifer, Venhorst, Wouter I, Iwema Bakker, Cor G, de Korte, Wouter, de Looff, Stefan, Verhoog, Jan-Willem, van Wees, Martijn, van Hoeve, Rob P, van de Woestijne, Martina A W, van der Neut, Alice J M, Borst, Maria J P, van Dongen, Natasja M W J, de Bruin, Hiskias G, Keizer, Chris G, Kruse
Publikováno v:
Journal of medicinal chemistry. 54(20)
The 5-HT(6) receptor (5-HT(6)R) has been in the spotlight for several years regarding CNS-related diseases. We set out to discover novel, neutral 5-HT(6)R antagonists to improve off-target selectivity compared to basic amine-containing scaffolds domi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::75ef008ee0bc37511a8ca06420a5a337
https://pubmed.ncbi.nlm.nih.gov/21866910
https://pubmed.ncbi.nlm.nih.gov/21866910
Autor:
David N. Reinhoudt, Wouter I. Iwema Bakker, Willem Verboom, E.S. van Dienst, Johannes F.J. Engbersen
Publikováno v:
ChemInform. 24
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::60db390abf60cb880eeafffc66c55d95
https://doi.org/10.1002/chin.199319294
https://doi.org/10.1002/chin.199319294
Publikováno v:
ChemInform. 29
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5cd03ff3e405d8e052fc47571e5b4d14
https://doi.org/10.1002/chin.199803059
https://doi.org/10.1002/chin.199803059
Autor:
Adri van den Hoogenband, Feenstra Roelof W, Wouter I. Iwema-Bakker, Jack A. J. den Hartog, Jan Willem Terpstra, Josephus H. M. Lange, Jord van Schaik
Publikováno v:
ChemInform. 37
An unprecedented synthetic approach to novel 4-aryl-1-methyloxindoles is described. The method involves the intramolecular palladium-catalyzed amidation of N-methyl-2,6-dibromophenylacetamide followed by an in situ Suzuki cross-coupling reaction with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::134538aededd63b090691f9309c6ca8a
https://doi.org/10.1002/chin.200640116
https://doi.org/10.1002/chin.200640116
Autor:
Adri van den Hoogenband, Andrew C. McCreary, Theo J.J. Zethof, Barbara Zijta, Guus J. M. van Scharrenburg, Herman H. van Stuivenberg, Wouter I. Iwema Bakker, Arie T. Mulder, Jan H. van Maarseveen
Publikováno v:
Bioorganic & Medicinal Chemistry Letters, 16(4), 1045-1048. Elsevier
The synthesis and structure-activity relations for a new class of centrally active NK-1 receptor antagonists are described. The new compounds are based on piperazine 2 and contain an oxime ether functionality. Several new compounds have high affinity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27a434b51e15de25ed8297438598a2bb
https://doi.org/10.1002/chin.200619152
https://doi.org/10.1002/chin.200619152
Autor:
Martin Berkheij, Dennis J. den Boer, Claudia Sewing, Jan H. van Maarseveen, Wouter I. Iwema Bakker, Jan Willem Terpstra, Lisan van der Sluis, Henk Hiemstra, Adri van den Hoogenband
Publikováno v:
Tetrahedron Letters, 46(14), 2369-2371. Elsevier
A novel efficient synthetic route towards the pharmaceutically relevant 2-substituted piperazine class is described. The key step involves α-lithiation of N-Boc piperazines, followed by reaction with several electrophiles. To obtain high yields, in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a8e56d8273e7515b33df40890bb4f13
https://doi.org/10.1002/chin.200530146
https://doi.org/10.1002/chin.200530146
