Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Wouter H. Gerritsen"'
Autor:
Maarten E. Witte, John G.J.M. Bol, Wouter H. Gerritsen, Paul van der Valk, Benjamin Drukarch, Jack van Horssen, Micha M.M. Wilhelmus
Publikováno v:
Neurobiology of Disease, Vol 36, Iss 3, Pp 445-452 (2009)
Parkin is implicated in the pathogenesis of Parkinson's disease. Furthermore, parkin targets misfolded proteins for degradation and protects cells against various forms of cellular stress, including unfolded-protein and oxidative stress. This points
Externí odkaz:
https://doaj.org/article/8244a30411234e8d9bd05be5a1a288fb
Autor:
Laura A. N. Peferoen, A L Görtz, Sandra Amor, Marianna Bugiani, Wouter H. Gerritsen, J M van Noort
Publikováno v:
Görtz, A L, Peferoen, L A N, Gerritsen, W H, van Noort, J M, Bugiani, M & Amor, S 2018, ' Heat shock protein expression in cerebral X-linked adrenoleukodystrophy reveals astrocyte stress prior to myelin loss ', Neuropathology and Applied Neurobiology, vol. 44, no. 4, pp. 363-376 . https://doi.org/10.1111/nan.12399
Neuropathology and Applied Neurobiology, 44(4), 363-376. Wiley-Blackwell
Neuropathology and Applied Neurobiology, 44(4), 363-376. Wiley-Blackwell
AIMS: X-linked adrenoleukodystrophy (X-ALD) is a genetic white matter disorder in which demyelination occurs due to accumulation of very long-chain fatty acids. Inflammation in the brain white matter is a hallmark of the pathology of cerebral X-ALD,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a54cbf8df0e40918e9eb72fbefc716a
https://doi.org/10.1111/nan.12399
https://doi.org/10.1111/nan.12399
Autor:
Hendrikus Boddeke, Paul van der Valk, Johannes M. van Noort, Malika Bsibsi, Markus Kipp, Wouter H. Gerritsen, Inge R. Holtman, Sandra Amor, Bart J. L. Eggen
Publikováno v:
Glia. 65:460-473
The glial stress protein alpha B-crystallin (HSPB5) is an endogenous agonist for Toll-like receptor 2 in CD14+ cells. Following systemic administration, HSPB5 acts as a potent inhibitor of neuroinflammation in animal models and reduces lesion develop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f01bae4d1fb50620277028f1271e614
https://doi.org/10.1002/glia.23104
https://doi.org/10.1002/glia.23104
Autor:
Wouter H. Gerritsen, Paul van der Valk, Sandra Amor, Kimberley Ummenthum, Daphne Y.S. Vogel, Priscilla D. A. M. Heijnen, Laura A. N. Peferoen, Christine D. Dijkstra, Marjolein Breur, Regina Peferoen-Baert
Publikováno v:
Journal of Neuropathology and Experimental Neurology, 74(1), 48-63. Lippincott Williams and Wilkins
Peferoen, L A N, Vogel, D Y S, Ummenthum, K, Breur, M, Heijnen, P D A M, Gerritsen, W H, Peferoen-Baert, R M B, van der Valk, P, Dijkstra, C D & Amor, S 2015, ' Activation Status of Human Microglia Is Dependent on Lesion Formation Stage and Remyelination in Multiple Sclerosis ', Journal of Neuropathology and Experimental Neurology, vol. 74, no. 1, pp. 48-63 . https://doi.org/10.1097/NEN.0000000000000149
Peferoen, L A N, Vogel, D Y S, Ummenthum, K, Breur, M, Heijnen, P D A M, Gerritsen, W H, Peferoen-Baert, R M B, van der Valk, P, Dijkstra, C D & Amor, S 2015, ' Activation Status of Human Microglia Is Dependent on Lesion Formation Stage and Remyelination in Multiple Sclerosis ', Journal of Neuropathology and Experimental Neurology, vol. 74, no. 1, pp. 48-63 . https://doi.org/10.1097/NEN.0000000000000149
Similar to macrophages, microglia adopt diverse activation states and contribute to repair and tissue damage in multiple sclerosis. Using reverse transcription-quantitative polymerase chain reaction and immunohistochemistry, we show that in vitro M1-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1780cc193d3fffc34ff8da559fb77337
https://doi.org/10.1097/nen.0000000000000149
https://doi.org/10.1097/nen.0000000000000149
Autor:
Malika Bsibsi, Wouter H. Gerritsen, Inge R. Holtman, Johannes M. van Noort, Paul van der Valk, Peter J. Nacken, Sandra Amor, Laura A. N. Peferoen, Bart J. L. Eggen, Jack van Horssen, Maarten E. Witte
Publikováno v:
Acta Neuropathologica, 128(2), 215-229. SPRINGER
Acta Neuropathologica, 128(2), 215-229. Springer Verlag
Bsibsi, M, Peferoen, L A N, Holtman, I R, Nacken, P J, Gerritsen, W H, Witte, M E, van Horssen, J, Eggen, B J L, van der Valk, P, Amor, S & van Noort, J M 2014, ' Demyelination during multiple sclerosis is associated with combined activation of microglia/macrophages by IFN-gamma and alpha B-crystallin ', Acta Neuropathologica, vol. 128, no. 2, pp. 215-229 . https://doi.org/10.1007/s00401-014-1317-8
Acta Neuropathologica, 128(2), 215-229. Springer Verlag
Bsibsi, M, Peferoen, L A N, Holtman, I R, Nacken, P J, Gerritsen, W H, Witte, M E, van Horssen, J, Eggen, B J L, van der Valk, P, Amor, S & van Noort, J M 2014, ' Demyelination during multiple sclerosis is associated with combined activation of microglia/macrophages by IFN-gamma and alpha B-crystallin ', Acta Neuropathologica, vol. 128, no. 2, pp. 215-229 . https://doi.org/10.1007/s00401-014-1317-8
Activated microglia and macrophages play a key role in driving demyelination during multiple sclerosis (MS), but the factors responsible for their activation remain poorly understood. Here, we present evidence for a dual-trigger role of IFN-gamma and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36a3cb320cba3eeeaedfc2f86f8b4c07
https://doi.org/10.1007/s00401-014-1317-8
https://doi.org/10.1007/s00401-014-1317-8
Autor:
Inge R, Holtman, Malika, Bsibsi, Wouter H, Gerritsen, Hendrikus W G M, Boddeke, Bart J L, Eggen, Paul, van der Valk, Markus, Kipp, Johannes M, van Noort, Sandra, Amor
Publikováno v:
Glia. 65(3)
The glial stress protein alpha B-crystallin (HSPB5) is an endogenous agonist for Toll-like receptor 2 in CD14
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::31b3d0d5322ba4ddf0bfdcc57aa6260c
https://pubmed.ncbi.nlm.nih.gov/28063173
https://pubmed.ncbi.nlm.nih.gov/28063173
Autor:
Bert van het Hof, Philip G. Nijland, Maarten E. Witte, Paul van der Valk, Jack van Horssen, Wouter H. Gerritsen, Dirk Geerts, Joost A. R. Drexhage, Arie Reijerkerk, Helga E. de Vries
Publikováno v:
Acta Neuropathologica, 125(2), 231-243. Springer Verlag
Acta Neuropathologica, 125(2), 231-43. Springer Verlag
Witte, M E, Nijland, P G, Drexhage, J A R, Gerritsen, W, Geerts, D, van Het Hof, B, Reijerkerk, A, de Vries, H E, van der Valk, P & van Horssen, J 2013, ' Reduced expression of PGC-1 alpha partly underlies mitochondrial changes and correlates with neuronal loss in multiple sclerosis cortex ', Acta Neuropathologica, vol. 125, no. 2, pp. 231-243 . https://doi.org/10.1007/s00401-012-1052-y
Acta Neuropathologica, 125(2), 231-43. Springer Verlag
Witte, M E, Nijland, P G, Drexhage, J A R, Gerritsen, W, Geerts, D, van Het Hof, B, Reijerkerk, A, de Vries, H E, van der Valk, P & van Horssen, J 2013, ' Reduced expression of PGC-1 alpha partly underlies mitochondrial changes and correlates with neuronal loss in multiple sclerosis cortex ', Acta Neuropathologica, vol. 125, no. 2, pp. 231-243 . https://doi.org/10.1007/s00401-012-1052-y
There is growing evidence that mitochondrial dysfunction and associated reactive oxygen species (ROS) formation contribute to neurodegenerative processes in multiple sclerosis (MS). Here, we investigated whether alterations in transcriptional regulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc49aa78ea271fcc8e86df3ffc50f729
https://doi.org/10.1007/s00401-012-1052-y
https://doi.org/10.1007/s00401-012-1052-y
Autor:
Sandra Amor, Samuel L. Jackson, David Baker, Sjef Copray, Falak Sher, Erik Boddeke, Wouter H. Gerritsen
Publikováno v:
Cell Transplantation, 21(9), 1883-1897. SAGE Publishing
Sher, F, Amor, S, Gerritsen, W H, Baker, D, Jackson, S L, Boddeke, E & Copray, S 2012, ' Intraventricularly Injected Olig2-NSCs Attenuate Established Relapsing-Remitting EAE in Mice ', Cell Transplantation, vol. 21, no. 9, pp. 1883-1897 . https://doi.org/10.3727/096368911X637443
Cell Transplantation, 21(9), 1883-1897. Cognizant Communication Corporation
Cell Transplantation, Vol 21 (2012)
Sher, F, Amor, S, Gerritsen, W H, Baker, D, Jackson, S L, Boddeke, E & Copray, S 2012, ' Intraventricularly Injected Olig2-NSCs Attenuate Established Relapsing-Remitting EAE in Mice ', Cell Transplantation, vol. 21, no. 9, pp. 1883-1897 . https://doi.org/10.3727/096368911X637443
Cell Transplantation, 21(9), 1883-1897. Cognizant Communication Corporation
Cell Transplantation, Vol 21 (2012)
In multiple sclerosis (MS), a chronic inflammatory relapsing demyelinating disease, failure to control or repair damage leads to progressive neurological dysfunction and neurodegeneration. Implantation of neural stem cells (NSCs) has been shown to pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cc0e876e5e2decc565f9c296d062ba6
https://doi.org/10.3727/096368911x637443
https://doi.org/10.3727/096368911x637443
Publikováno v:
Multiple Sclerosis, 17(6), 647-657. SAGE Publications Ltd
Baker, D, Gerritsen, W H, Rundle, J & Amor, S 2011, ' Critical appraisal of animal models of multiple sclerosis ', Multiple Sclerosis, vol. 17, no. 6, pp. 647-657 . https://doi.org/10.1177/1352458511398885
Baker, D, Gerritsen, W H, Rundle, J & Amor, S 2011, ' Critical appraisal of animal models of multiple sclerosis ', Multiple Sclerosis, vol. 17, no. 6, pp. 647-657 . https://doi.org/10.1177/1352458511398885
Experimental autoimmune encephalomyelitis (EAE) is a spectrum of neurological disorders in laboratory animals that is used to model multiple sclerosis (MS). However, few agents have translated from efficacy in EAE to the treatment of human disease. A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::685293d8026e4dcc365f61214419ed1b
https://doi.org/10.1177/1352458511398885
https://doi.org/10.1177/1352458511398885
Autor:
M. Prins, Eleonora Aronica, Wouter H. Gerritsen, Anne-Marie van Dam, Jeroen J.M. Hoozemans, Paul van der Valk, Evert-Jan Kooi, Paul T. Francis, Jeroen J. G. Geurts, Jack van Horssen, Jeroen A.M. Beliën, Natasha Bajic
Publikováno v:
Acta neuropathologica, 122(3), 313-322. Springer Verlag
Acta Neuropathologica, 122(3), 313-322. Springer Verlag
Acta Neuropathologica
Kooi, E-J, Prins, M, Bajic, N, Beliën, J A M, Gerritsen, W H, van Horssen, J, Aronica, E, van Dam, A-M, Hoozemans, J J M, Francis, P T, van der Valk, P & Geurts, J J G 2011, ' Cholinergic imbalance in the multiple sclerosis hippocampus ', Acta Neuropathologica, vol. 122, no. 3, pp. 313-322 . https://doi.org/10.1007/s00401-011-0849-4
Acta Neuropathologica, 122(3), 313-322. Springer Verlag
Acta Neuropathologica
Kooi, E-J, Prins, M, Bajic, N, Beliën, J A M, Gerritsen, W H, van Horssen, J, Aronica, E, van Dam, A-M, Hoozemans, J J M, Francis, P T, van der Valk, P & Geurts, J J G 2011, ' Cholinergic imbalance in the multiple sclerosis hippocampus ', Acta Neuropathologica, vol. 122, no. 3, pp. 313-322 . https://doi.org/10.1007/s00401-011-0849-4
Hippocampal pathology was shown to be extensive in multiple sclerosis (MS) and is associated with memory impairment. In this post-mortem study, we investigated hippocampal tissue from MS and Alzheimer's disease (AD) patients and compared these to non
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6246ccd249b5f4e7475f7e7501d13a85
https://doi.org/10.1007/s00401-011-0849-4
https://doi.org/10.1007/s00401-011-0849-4