Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Wouter Goutier"'
Autor:
Bart Stoops, Rob J. Vreeken, Chan Tang, Wim Bert Griet Schepens, Rameshwar U. Kadam, Jaap Goudsmit, Bart Rudolf Romanie Kesteleyn, Maria J. P. van Dongen, Wouter Goutier, Jan Vermond, Ronald Vogels, Boerries Brandenburg, Ian A. Wilson, Jarek Juraszek, Christophe Buyck, Robert H. E. Friesen
Publikováno v:
Science. 358:496-502
Broadly reactive drugs for flu Drugs for influenza are limited. For those available, viral resistance is rife. Part of the problem is that the virus is constantly mutating. Kadam et al. tested the cell entry stage of the virus life cycle as a drug ta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3194b81b5624b59d020e5f61404c9763
https://doi.org/10.1126/science.aan0516
https://doi.org/10.1126/science.aan0516
Autor:
Dirk Roymans, Wim Bert Griet Schepens, Danielle Peeters, Jaap Goudsmit, Maria J. P. van Dongen, Wenli Yu, Ronald Vogels, Bart Stoops, Boerries Brandenburg, J.M. Klap, Edward C. Lawson, Tim H. M. Jonckers, Mandy Jongeneelen, Harry A. van Diepen, Sven Blokland, Chan Tang, Wouter Goutier, Christophe Buyck, Ellen Lanckacker, Ian A. Wilson, Jan Vermond, P. Roevens, Wouter Koudstaal, Jin Wu, Frederike Schmitz, Rameshwar U. Kadam, Jarek Juraszek, Alida van Eijgen-Obregoso Real, Dashyant Dhanak, Pierre Jean-Marie Bernard Raboisson, Robert Heinz Edward Friesen, Divita Garg
Publikováno v:
Science. 363
A small molecule that targets influenza Many of us rely on seasonal vaccines for protection against influenza and are only too aware of their limited breadth. Broadly neutralizing antibodies (bnAbs) that target the conserved hemagglutinin (HA) stem o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cc89b6e36809f142eda1c2131f1632b
https://doi.org/10.1126/science.aar6221
https://doi.org/10.1126/science.aar6221
Publikováno v:
Addiction Biology. 21:234-241
There are a number of approved therapeutics for the management of alcohol dependence, which might also convey the potential as smoking cessation aids. The present study investigated the effect of a few of these therapeutics and potential candidates (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54d8284451b81ee2d0e63eb840ee96ef
https://doi.org/10.1111/adb.12190
https://doi.org/10.1111/adb.12190
Publikováno v:
Addiction Biology. 20:248-258
The present study focused on the evaluation of behavioral sensitization and cross-sensitization induced by nicotine and varenicline in rats. Furthermore, it examined the influence of varenicline, a partial alpha4beta2 nicotinic receptor agonist, on n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41c57dec53754bb10b15af327a5ec8de
https://doi.org/10.1111/adb.12108
https://doi.org/10.1111/adb.12108
Publikováno v:
Addiction biology. 21(2)
There are a number of approved therapeutics for the management of alcohol dependence, which might also convey the potential as smoking cessation aids. The present study investigated the effect of a few of these therapeutics and potential candidates (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f2b94b0218953f504452958d7796d1c6
https://pubmed.ncbi.nlm.nih.gov/25307867
https://pubmed.ncbi.nlm.nih.gov/25307867
Publikováno v:
Addiction biology. 20(2)
The present study focused on the evaluation of behavioral sensitization and cross-sensitization induced by nicotine and varenicline in rats. Furthermore, it examined the influence of varenicline, a partial alpha4beta2 nicotinic receptor agonist, on n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::01e6e1f0f49ae524983a8427d5e4b8a1
https://pubmed.ncbi.nlm.nih.gov/24251901
https://pubmed.ncbi.nlm.nih.gov/24251901
Publikováno v:
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 25(6)
Behavioral sensitization is a phenomenon which can develop following repeated intermittent administration of a wide range of psychostimulants. The mechanism underlying this phenomenon is putatively involved in many neuropsychiatric disorders (incl. d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be152e3208d300e59b1bd12fe7ba60b0
https://pubmed.ncbi.nlm.nih.gov/25795518
https://pubmed.ncbi.nlm.nih.gov/25795518
Autor:
Henri C. Wals, Vliet Bernard J Van, Josephus H. M. Lange, Alice J.M. Borst, Hicham Zilaout, Gijs D. Kuil, Martina A.W. van der Neut, Herman H. van Stuivenberg, Arnold P. den Hartog, Arie T. Mulder, Wouter Goutier
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(3)
The synthesis and structure–activity relationship studies of imidazoles are described. The target compounds 6 – 20 represent a novel chemotype of potent and CB 2 /CB 1 selective cannabinoid CB 2 receptor antagonists/inverse agonists with very hig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d05bca00ba102b73cff12dc1d1f7d3f9
https://pubmed.ncbi.nlm.nih.gov/20031412
https://pubmed.ncbi.nlm.nih.gov/20031412
Autor:
Sharon Rosenzweig-Lipson, Deborah L. Smith, Feenstra Roelof W, Steven M. Grauer, Pierre Broqua, Rachel Navarra, David P. Rotella, Mark H. Pausch, Karen L. Marquis, Radka Graf, Albert J. Robichaud, Martina Van De Neut, Qian Lin, Claudine Pulicicchio, Farhana Pruthi, Wouter Goutier, Chad E. Beyer, Caitlin Wantuch, Julie A. Brennan, Zoë A. Hughes, Andrew C. McCreary, Margaret Lai, Chris G. Kruse
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 332(1)
The preclinical characterization of WS-50030 [7-{4-[3-(1H-inden-3-yl)propyl]piperazin-1-yl}-1,3-benzoxazol-2(3H)-one] is described. In vitro binding and functional studies revealed highest affinity to the D(2) receptor (D(2L) K(i), 4.0 nM) and seroto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca7b9cd3292b351096e029c21f167643
https://pubmed.ncbi.nlm.nih.gov/19828876
https://pubmed.ncbi.nlm.nih.gov/19828876