IP-LC-MSMS Enables Identification of Three Tau O-GlcNAcylation Sites as O-GlcNAcase Inhibition Pharmacodynamic Readout in Transgenic Mice Overexpressing Human Tau

Autor: Sebastiaan Bijttebier, Dina Rodrigues Martins, Liesbeth Mertens, Karolien Grauwen, Wouter Bruinzeel, Roland Willems, José Manuel Bartolomé-Nebreda, Clara Theunis, Alexis Bretteville, Andreas Ebneth, Lieve Dillen

Publikováno v: Journal of Proteome Research. 22:1309-1321

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::93055646cca8e6b19373c144611dd86f
https://doi.org/10.1021/acs.jproteome.2c00822

Binding of a potent small-molecule inhibitor of six-helix bundle formation requires interactions with both heptad-repeats of the RSV fusion protein

Autor: Maxwell D. Cummings, Jean-François Bonfanti, Peggy Geluykens, Dirk Roymans, Hidong Kim, Hendrik L. De Bondt, Wouter Bruinzeel, Marcia Van Ginderen, Koen Andries, Herman W. T. van Vlijmen, Eric Arnoult, Rudy Edmond Willebrords, Nick Verheyen, Tom Valerius Josepha Gevers

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences

Six-helix bundle (6HB) formation is an essential step for many viruses that rely on a class I fusion protein to enter a target cell and initiate replication. Because the binding modes of small molecule inhibitors of 6HB formation are largely unknown,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baa78f39779ca09c78e2dbb7fcf73fcf
https://hdl.handle.net/10067/810200151162165141