Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Wouter A. van Winden"'
Autor:
Wenjun Tang, Henk J. Noorman, Walter M. van Gulik, Cees Haringa, Robert F. Mudde, Guan Wang, Ju Chu, Amit T. Deshmukh, Joseph J. Heijnen, Wouter A. van Winden
Publikováno v:
Chemical Engineering Science, 175
We assess the effect of substrate heterogeneity on the metabolic response of P. chrysogenum in industrial bioreactors via the coupling of a 9-pool metabolic model with Euler-Lagrange CFD simulations. In this work, we outline how this coupled hydrodyn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59b40fd42bb84937119f10c3266d539c
https://doi.org/10.1016/j.ces.2017.09.020
https://doi.org/10.1016/j.ces.2017.09.020
Autor:
Jianye Xia, Walter M. van Gulik, Amit T. Deshmukh, Cees Haringa, Guan Wang, Matthias Reuss, Wenjun Tang, Wouter A. van Winden, Joseph J. Heijnen, Henk J. Noorman, Ju Chu
Publikováno v:
Biotechnology and Bioengineering. 114:1733-1743
A powerful approach for the optimization of industrial bioprocesses is to perform detailed simulations integrating large-scale computational fluid dynamics (CFD) and cellular reaction dynamics (CRD). However, complex metabolic kinetic models containi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a300f6464d7f0cc85f33a9aca9b674f1
https://doi.org/10.1002/bit.26294
https://doi.org/10.1002/bit.26294
Autor:
Walter M. van Gulik, Wouter A. van Winden, Octavio T. Ramírez, Hilal Taymaz-Nikerel, Mlawule R. Mashego, Alvaro R. Lara, Joseph J. Heijnen
Publikováno v:
Biotechnology and Bioengineering. 104:1153-1161
The response of Escherichia coli cells to transient exposure (step increase) in substrate concentration and anaerobiosis leading to mixed-acid fermentation metabolism was studied in a two-compartment bioreactor system consisting of a stirred tank rea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::716ec2fdccde36e42f5878734e651252
https://doi.org/10.1002/bit.22503
https://doi.org/10.1002/bit.22503
Autor:
Joseph J. Heijnen, Cor Ras, Peter J.T. Verheijen, Walter M. van Gulik, Zheng Zhao, Wouter A. van Winden, Karel Kuijvenhoven
Publikováno v:
Metabolic Engineering. 10:178-186
Current (13)C labeling experiments for metabolic flux analysis (MFA) are mostly limited by either the requirement of isotopic steady state or the extremely high computational effort due to the size and complexity of large metabolic networks. The pres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5d4252e350afa10f6c9a9648cf7fe59
https://doi.org/10.1016/j.ymben.2008.04.003
https://doi.org/10.1016/j.ymben.2008.04.003
Autor:
Joseph J. Heijnen, Wouter A. van Winden, Reza M. Seifar, Zheng Zhao, Jan van Dam, Walter M. van Gulik
Publikováno v:
Journal of Chromatography A. 1187:103-110
A rapid, sensitive and selective ion-pair reversed-phase liquid chromatography-electrospray ionization isotope dilution tandem mass spectrometry (IP-LC-ESI-ID-MS/MS) was developed for quantitative analysis of free intracellular metabolites in cell cu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c98d74b5ae176527716525155a856147
https://doi.org/10.1016/j.chroma.2008.02.008
https://doi.org/10.1016/j.chroma.2008.02.008
Autor:
Jack T. Pronk, Jan-Maarten A. Geertman, Antonius J. A. van Maris, Wouter A. van Winden, Dick Schipper, Cor Ras, Joseph J. Heijnen, Roelco J. Kleijn, Beckley K. Nfor
Publikováno v:
FEMS Yeast Research. 7:216-231
This study focuses on unravelling the carbon and redox metabolism of a previously developed glycerol-overproducing Saccharomyces cerevisiae strain with deletions in the structural genes encoding triosephosphate isomerase ( TPI1 ), the external mitoch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a2cc58f35bdc5a44613de87118658e1
https://doi.org/10.1111/j.1567-1364.2006.00180.x
https://doi.org/10.1111/j.1567-1364.2006.00180.x
Autor:
Walter M. van Gulik, Feng Liu, Cor Ras, Joseph J. Heijnen, Roelco J. Kleijn, Wouter A. van Winden
Publikováno v:
Metabolic Engineering. 9:112-123
This study addresses the relation between NADPH supply and penicillin synthesis, by comparing the flux through the oxidative branch of the pentose phosphate pathway (PPP; the main source of cytosolic NADPH) in penicillin-G producing and non-producing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5d2b396be6e042da9cf9527e68c5a7a
https://doi.org/10.1016/j.ymben.2006.08.004
https://doi.org/10.1016/j.ymben.2006.08.004
Autor:
Joseph J. Heijnen, Cor Ras, Walter M. van Gulik, Roelco J. Kleijn, Wouter A. van Winden, Dick Schipper
Publikováno v:
Applied and Environmental Microbiology. 72:4743-4754
In this study we developed a new method for accurately determining the pentose phosphate pathway (PPP) split ratio, an important metabolic parameter in the primary metabolism of a cell. This method is based on simultaneous feeding of unlabeled glucos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6eacad8c3612531fed3b1dff7742624
https://doi.org/10.1128/aem.02955-05
https://doi.org/10.1128/aem.02955-05
Publikováno v:
FEBS Journal. 272:4970-4982
The currently applied reaction structure in stoichiometric flux balance models for the nonoxidative branch of the pentose phosphate pathway is not in accordance with the established ping-pong kinetic mechanism of the enzymes transketolase (EC 2.2.1.1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a268cb7bb7b69b169017cf1066a14d7d
https://doi.org/10.1111/j.1742-4658.2005.04907.x
https://doi.org/10.1111/j.1742-4658.2005.04907.x
Autor:
Wouter A. van Winden, Jan C. van Dam, Roelco J. Kleijn, Joseph J. Heijnen, J. L. Vinke, Walter M. van Gulik, Cor Ras
Publikováno v:
FEMS Yeast Research. 5:559-568
Metabolic-flux analyses in microorganisms are increasingly based on 13C-labeling data. In this paper a new approach for the measurement of 13C-label distributions is presented: rapid sampling and quenching of microorganisms from a cultivation, follow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5868e9b73d332f328cd36993a62fe3a6
https://doi.org/10.1016/j.femsyr.2004.10.007
https://doi.org/10.1016/j.femsyr.2004.10.007