Polo-like kinase-1 controls Aurora A destruction by activating APC/C-Cdh1.

Autor: Renske van Leuken, Linda Clijsters, Wouter van Zon, Dan Lim, XueBiao Yao, Rob M F Wolthuis, Michael B Yaffe, René H Medema, Marcel A T M van Vugt

Publikováno v: PLoS ONE, Vol 4, Iss 4, p e5282 (2009)

Polo-like kinase-1 (Plk1) is activated before mitosis by Aurora A and its cofactor Bora. In mitosis, Bora is degraded in a manner dependent on Plk1 kinase activity and the E3 ubiquitin ligase SCF-betaTrCP. Here, we show that Plk1 is also required for

Externí odkaz: https://doaj.org/article/5bdd7095f17b43e5addb2cbe505d25b1

Cell Cycle Heterogeneity Can Generate Robust Cell Type Proportioning

Autor: Nicole, Gruenheit, Katie, Parkinson, Christopher A, Brimson, Satoshi, Kuwana, Edward J, Johnson, Koki, Nagayama, Jack, Llewellyn, William M, Salvidge, Balint, Stewart, Thomas, Keller, Wouter, van Zon, Simon L, Cotter, Christopher R L, Thompson

Publikováno v: Developmental Cell

Summary Cell-cell heterogeneity can facilitate lineage choice during embryonic development because it primes cells to respond to differentiation cues. However, remarkably little is known about the origin of heterogeneity or whether intrinsic and extr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8b607e897a7e607f91f509859e1ee801
https://pubmed.ncbi.nlm.nih.gov/30473004

Cyclin A and Nek2A: APC/C-Cdc20 substrates invisible to the mitotic spindle checkpoint

Autor: Rob M. F. Wolthuis, Wouter van Zon

Publikováno v: Biochemical Society transactions. 38(Pt 1)

Active cyclin B1–Cdk1 (cyclin-dependent kinase 1) keeps cells in mitosis, allowing time for spindle microtubules to capture the chromosomes and for incorrect chromosome-spindle attachments to be repaired. Meanwhile, securin, an inhibitor of separas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c003b8315b350641a485c5211953c59c
https://pubmed.ncbi.nlm.nih.gov/20074038

The cellular phenotype of Roberts syndrome fibroblasts as revealed by ectopic expression of ESCO2

Autor: Barbara C. Godthelp, Jan de Groot, Firouz Darroudi, Rob M. F. Wolthuis, Djoke van Gosliga, Anneke B. Oostra, Quinten Waisfisz, Petra van der Lelij, Johan P. de Winter, Rik J. Scheper, Jurgen Steltenpool, Wouter van Zon, Hans Joenje

Publikováno v: PLoS ONE, Vol 4, Iss 9, p e6936 (2009)
PLoS ONE
PLoS ONE, 4(9). Public Library of Science
van der Lelij, P, Godthelp, B C, van Zon, W, van Gosliga, D, Oostra, A B, Steltenpool, J, de Groot, J, Scheper, R J, Wolthuis, R M, Waisfisz, Q, Darroudi, F, Joenje, H & de Winter, J P 2009, ' The Cellular Phenotype of Roberts Syndrome Fibroblasts as Revealed by Ectopic Expression of ESCO2 ', PLoS ONE, vol. 4, no. 9 . https://doi.org/10.1371/joumal.pone.0006936

Cohesion between sister chromatids is essential for faithful chromosome segregation. In budding yeast, the acetyltransferase Eco1/Ctf7 establishes cohesion during DNA replication in S phase and in response to DNA double strand breaks in G2/M phase. I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca4e386443523653d0820c5812f203c2
http://europepmc.org/articles/PMC2734174?pdf=render

Cdc20 and Cks direct the spindle checkpoint-independent destruction of cyclin A

Autor: Lars Koop, René H. Medema, Jonathon Pines, Wouter van Zon, Rob M. F. Wolthuis, Mona Yekezare, Lori Clay-Farrace, Janneke Ogink

Publikováno v: Molecular Cell, 30(3), 290-302. CELL PRESS

Successful mitosis requires the right protein be degraded at the right time. Central to this is the spindle checkpoint that prevents the destruction of securin and cyclin 131 when there are improperly attached chromosomes. The principal target of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::590c1507c02ccd8bc7c251a8354fb56d
https://research.rug.nl/en/publications/a424176c-06ee-4a5b-ae00-9a3567e5c026