Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Woul-Seong Park"'
Autor:
Kwangseok Ko, Chan Hee Park, Seung-Su Oh, Young Jin Kwon, Jung-Sook Kim, Eun-Jung Park, Woul-Seong Park, Soon Ok Lee, D.H. Yoon, Woon-Ki Cho, Yu-Mi Song, Kyoung-June Lee, Cho-Rong Min, Jieun Lee, Kazumi Morikawa, Ju-Han Yoon, Pil-Su Ho, Hye Jung Kim, Jee-Hun Yun, Yu Chul Kim
Publikováno v:
Journal of Medicinal Chemistry. 61:2949-2961
The histamine H4 receptor (H4R), a member of the G-protein coupled receptor family, has been considered as a potential therapeutic target for treating atopic dermatitis (AD). A large number of H4R antagonists have been disclosed, but no efficient age
Publikováno v:
Ocean Systems Engineering. 5:109-123
In the present study, the coupled dynamic response of a Submerged Floating Tunnel (SFT) and mooring lines under regular waves is solved by using two independent numerical simulation methods, OrcaFlex and CHARM3D, in time domain. Variations of Buoyanc
Autor:
Banda Narsaiah, Woul Seong Park, Sung-Soo Kim, Seung Kyu Kang, Jin Hee Ahn, Myung Ae Bae, Duck-Hyung Lee, Mi Sik Shin, Mi Ae Jun, Ki Young Kim, Hyae Gyeong Cheon, Sang Dal Rhee, Kwon Sung-Wook
Publikováno v:
Journal of Fluorine Chemistry. 130:1001-1010
A series of triazepane derivatives such as (R)-3-amino-1-(1,2,5-triazepan-1-yl)-4-(2,4,5-trifluorophenyl)butan-1-ones (7, 13a–p) and (R)-3-amino-1-(1,2,5-triazepan-5-yl)-4-(2,4,5-trifluorophenyl)butan-1-ones (17a–e) was synthesized and evaluated
Autor:
Sang Dal Rhee, Hyae Gyeong Cheon, Nam Sook Kang, Mi Sik Shin, Seung Kyu Kang, Jie Oh Lee, Jin Hee Ahn, Myung Ae Bae, Ki Young Kim, Woul Seong Park, Sung Gyu Kim, Sun Young Kim, Duck-Hyung Lee, Sung-Soo Kim, Sang Kwon Sohn, Mi Ae Jun, Kwang Rok Kim
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:6525-6529
Compounds with homopiperazine skeleton are designed to find a potent DPP-IV inhibitor without inhibiting CYP. Thus a series of β-aminoacyl-containing homopiperazine derivatives was synthesized and evaluated. Compounds with acid moiety were found to
Autor:
Sung-Soo Kim, Ki Young Kim, Woul Seong Park, Seung Kyu Kang, Mi Ae Jun, Jin Hee Ahn, Sang Dal Rhee, Mi Sik Shin, Duck-Hyung Lee, Hyae Gyeong Cheon
Publikováno v:
Bulletin of the Korean Chemical Society. 29:2129-2134
Department of Chemistry, Sogang University, Seoul 121-742, KoreaReceived August 3, 2008In continuation of our efforts to further derivatize dipeptidyl peptidase IV (DPP-IV) inhibitors, a series of β-aminoacyl-containing 5-, 6- and 7- membered cyclic
Autor:
Ki Ho Lee, Jae Du Ha, Sang-Hyeup Lee, Seung Jun Kim, Sung-Soo Kim, Dae Gwin Jeong, Hwan Mook Kim, Chang Woo Lee, Woul Seong Park, Suk-Kyeong Jung, Joong-Kwon Choi, Song Kyu Park, Sung Yun Cho, Seong Eon Ryu, Seung Kyu Kang, Jin Hee Ahn
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:2996-2999
A series of rhodanine derivatives was synthesized and evaluated for their ability to inhibit PRL-3. Benzylidene rhodanine derivative showed good biological activity, while compound 5e was the most active in this series exhibiting an IC50 value of 0.9
Publikováno v:
Bulletin of the Korean Chemical Society. 31:2709-2711
Unnatural amino acids are widely utilized as biological active compounds and synthetic intermediates. Among them, thiazol-idine-2-carboxylic acid, which is an unnatural cyclic amino acid, was found in medicinal and organic chemistry area, many of whi
Autor:
Min-Sun Kim, Seung Kyu Kang, Jin Hee Ahn, Myung Ae Bae, Dong Hyun Song, Nam Sook Kang, Sang Dal Rhee, Mi Ae Jun, Kwang Rok Kim, Stephen Schneider, Woul Seong Park, Jie Oh Lee, Sung-Soo Kim, Peter Silinski, Ki-Young Kim, Sung-Eun Yoo, Mi Sik Shin
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(5)
A series of β-aminoacyl containing thiazolidine derivatives was synthesized and evaluated for their ability to inhibit DPP-IV. Several thiazolidine derivatives with an acid moiety were found to be potent DPP-IV inhibitors. Among them, compound 2da i
Autor:
Ki Young Kim, Woul Seong Park, Seung Kyu Kang, Sung-Soo Kim, Jin Hee Ahn, Mi Ae Jun, Sang Dal Rhee, Mi Sik Shin, Duck-Hyung Lee, Hyae Gyeong Cheon
Publikováno v:
ChemInform. 40
Department of Chemistry, Sogang University, Seoul 121-742, KoreaReceived August 3, 2008In continuation of our efforts to further derivatize dipeptidyl peptidase IV (DPP-IV) inhibitors, a series of β-aminoacyl-containing 5-, 6- and 7- membered cyclic
Autor:
Sung Gyu Kim, Seung Kyu Kang, Jin Hee Ahn, Myung Ae Bae, Mi Ae Jun, Kwang Rok Kim, Sang-Kwon Sohn, Duck-Hyung Lee, Sung-Soo Kim, Hyae Gyeong Cheon, Woul Seong Park, Ki Young Kim, Sang Dal Rhee, Nam Sook Kang, Jie Oh Lee
Publikováno v:
European journal of medicinal chemistry. 43(9)
A series of pyrazoline derivatives with beta-amino acyl group were synthesized and evaluated for their ability to inhibit dipeptidyl peptidase IV. Several pyrazoline derivatives exhibited submicromolar inhibitory activities against DPP-IV. X-ray co-c