Polymorphisms in the heme oxygenase-1 and bone morphogenetic protein receptor type 1b genes and estimated glomerular filtration rate in Brazilian sickle cell anemia patients

Autor: Magnun N. N. Santos, Okeke Chinedu, Igor de Farias Domingos, Aderson S Araujo, Maria de Fátima Sonati, Marcos André Cavalcanti Bezerra, Wouitchékpo Vincent Tonassé, Dulcineia M. Albuquerque

Publikováno v: Hematology, Transfusion and Cell Therapy, Volume: 43, Issue: 2, Pages: 165-170, Published: 07 JUL 2021
Hematology, Transfusion and Cell Therapy, Vol 43, Iss 2, Pp 165-170 (2021)
Hematology, Transfusion and Cell Therapy

Introduction Mutations affecting genes involved in oxidative and signaling pathways may be associated with kidney disease in sickle cell anemia. We determined the allele and genotype frequencies of some polymorphisms in the promoter regions of the He

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e617ffa144cc27fe6880e900e7b49f72
https://doi.org/10.1016/j.htct.2020.01.009

Endothelial Barrier Integrity Is Disrupted In Vitro by Heme and by Serum From Sickle Cell Disease Patients

Autor: Vanessa Araujo Gomes Santaterra, Maiara Marx Luz Fiusa, Bidossessi Wilfried Hounkpe, Francine Chenou, Wouitchekpo Vincent Tonasse, Loredana Nilkenes Gomes da Costa, Diego Garcia-Weber, Igor de Farias Domingos, Franciele de Lima, Ivanio Teixeira Borba-Junior, Aderson da Silva Araújo, Antonio Roberto Lucena-Araújo, Marcos André Cavalcante Bezerra, Magnun Nueldo Nunes dos Santos, Fernando Ferreira Costa, Jaime Millán, Erich Vinicius De Paula

Publikováno v: Frontiers in Immunology, Vol 11 (2020)

Free extracellular heme has been shown to activate several compartments of innate immunity, acting as a danger-associated molecular pattern (DAMP) in hemolytic diseases. Although localized endothelial barrier (EB) disruption is an important part of i

Externí odkaz: https://doaj.org/article/68ef82d31e9d4903aea19036d7c741a4