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Mechanisms of vascular smooth muscle cell investment and phenotypic diversification in vascular diseases.

Autor: Worssam, Matthew D., Jørgensen, Helle F.

Publikováno v: Biochemical Society Transactions; Nov2021, Vol. 49 Issue 5, p2101-2111, 11p

Epigenetic Regulation of Vascular Smooth Muscle Cells by Histone H3 Lysine 9 Dimethylation Attenuates Target Gene-Induction by Inflammatory Signaling

Autor: Harman, Jennifer L, Dobnikar, Lina, Chappell, Joel, Stokell, Benjamin G, Dalby, Amanda, Foote, Kirsty, Finigan, Alison, Freire-Pritchett, Paula, Taylor, Annabel L, Worssam, Matthew D, Madsen, Ralitsa R, Loche, Elena, Uryga, Anna, Bennett, Martin R, Jørgensen, Helle F

OBJECTIVE: Vascular inflammation underlies cardiovascular disease. Vascular smooth muscle cells (VSMCs) upregulate selective genes, including MMPs (matrix metalloproteinases) and proinflammatory cytokines upon local inflammation, which directly contr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e4134f1ebe7f13d8c2683d4572be1474

Network-based prioritization and validation of regulators of vascular smooth muscle cell proliferation in disease.

Autor: Lambert J; Section of Cardiorespiratory Medicine, Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK., Oc S; Section of Cardiorespiratory Medicine, Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK.; Functional Gene Control Group, MRC Laboratory of Medical Sciences, London, UK.; Institute of Clinical Sciences, Faculty of Medicine, Imperial College, London, UK., Worssam MD; Section of Cardiorespiratory Medicine, Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK.; Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA., Häußler D; TUM School of Medicine and Health, Institute of Experimental Oncology and Therapy Research, Technical University of Munich, Munich, Germany., Solomon CU; Department of Cardiovascular Sciences, University of Leicester, and National Institute for Health Research Leicester Biomedical Research Centre, Leicester, UK., Figg NL; Section of Cardiorespiratory Medicine, Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK., Baxter R; Section of Cardiorespiratory Medicine, Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK., Imaz M; Section of Cardiorespiratory Medicine, Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK., Taylor JCK; Section of Cardiorespiratory Medicine, Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK., Foote K; Section of Cardiorespiratory Medicine, Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK., Finigan A; Section of Cardiorespiratory Medicine, Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK., Mahbubani KT; Collaborative Biorepository for Translational Medicine, Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge, UK., Webb TR; Department of Cardiovascular Sciences, University of Leicester, and National Institute for Health Research Leicester Biomedical Research Centre, Leicester, UK., Ye S; Department of Cardiovascular Sciences, University of Leicester, and National Institute for Health Research Leicester Biomedical Research Centre, Leicester, UK.; Shantou University Medical College, Shantou, China.; Cardiovascular and Metabolic Disease Translational Research Programme, National University of Singapore, Singapore, Singapore., Bennett MR; Section of Cardiorespiratory Medicine, Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK., Krüger A; TUM School of Medicine and Health, Institute of Experimental Oncology and Therapy Research, Technical University of Munich, Munich, Germany., Spivakov M; Functional Gene Control Group, MRC Laboratory of Medical Sciences, London, UK.; Institute of Clinical Sciences, Faculty of Medicine, Imperial College, London, UK., Jørgensen HF; Section of Cardiorespiratory Medicine, Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge, UK. Hfj22@cam.ac.uk.

Publikováno v: Nature cardiovascular research [Nat Cardiovasc Res] 2024 Jun; Vol. 3 (6), pp. 714-733. Date of Electronic Publication: 2024 Jun 06.