Resequencing Study Confirms That Host Defense and Cell Senescence Gene Variants Contribute to the Risk of Idiopathic Pulmonary Fibrosis

Autor: Moore, Camille, Blumhagen, Rachel Z, Yang, Ivana V, Walts, Avram, Powers, Julie, Walker, Tarik, Bishop, Makenna, Russell, Pamela, Vestal, Brian, Cardwell, Jonathan, Markin, Cheryl R, Mathai, Susan K, Schwarz, Marvin I, Steele, Mark P, Lee, Joyce, Brown, Kevin K, Loyd, James E, Crapo, James D, Silverman, Edwin K, Cho, Michael H, James, Judith A, Guthridge, Joel M, Cogan, Joy D, Kropski, Jonathan A, Swigris, Jeffrey J, Bair, Carol, Kim, Dong Soon, Ji, Wonjun, Kim, Hocheol, Song, Jin Woo, Maier, Lisa A, Pacheco, Karin A, Hirani, Nikhil, Poon, Azin S, Li, Feng, Jenkins, R Gisli, Braybrooke, Rebecca, Saini, Gauri, Maher, Toby M, Molyneaux, Philip L, Saunders, Peter, Zhang, Yingze, Gibson, Kevin F, Kass, Daniel J, Rojas, Mauricio, Sembrat, John, Wolters, Paul J, Collard, Harold R, Sundy, John S, O'Riordan, Thomas, Strek, Mary E, Noth, Imre, Ma, Shwu-Fan, Porteous, Mary K, Kreider, Maryl E, Patel, Namrata B, Inoue, Yoshikazu, Hirose, Masaki, Arai, Toru, Akagawa, Shinobu, Eickelberg, Oliver, Fernandez, Isis Enlil, Behr, Jürgen, Mogulkoc, Nesrin, Corte, Tamera J, Glaspole, Ian, Tomassetti, Sara, Ravaglia, Claudia, Poletti, Venerino, Crestani, Bruno, Borie, Raphael, Kannengiesser, Caroline, Parfrey, Helen, Fiddler, Christine, Rassl, Doris, Molina-Molina, Maria, Machahua, Carlos, Worboys, Ana Montes, Gudmundsson, Gunnar, Isaksson, Helgi J, Lederer, David J, Podolanczuk, Anna J, Montesi, Sydney B, Bendstrup, Elisabeth, Danchel, Vivi, Selman, Moises, Pardo, Annie, Henry, Michael T, Keane, Michael P, Doran, Peter, Vašáková, Martina, Sterclova, Martina, Ryerson, Christopher J, Wilcox, Pearce G, Okamoto, Tsukasa, Furusawa, Haruhiko, Miyazaki, Yasunari, Laurent, Geoffrey, Baltic, Svetlana, Prele, Cecilia

Publikováno v: American journal of respiratory and critical care medicine, vol 200, iss 2

Rationale: Several common and rare genetic variants have been associated with idiopathic pulmonary fibrosis, a progressive fibrotic condition that is localized to the lung. Objectives: To develop an integrated understanding of the rare and common var

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::5035bfc2a0d840a5be58eb1ca7838e79
https://escholarship.org/uc/item/5cw3q5dq

Resequencing Study Confirms That Host Defense and Cell Senescence Gene Variants Contribute to the Risk of Idiopathic Pulmonary Fibrosis.

Autor: Moore C; 1 National Jewish Health, Denver, Colorado.; 2 School of Public Health., Blumhagen RZ; 1 National Jewish Health, Denver, Colorado.; 2 School of Public Health., Yang IV; 3 Department of Medicine, and., Walts A; 3 Department of Medicine, and., Powers J; 3 Department of Medicine, and., Walker T; 3 Department of Medicine, and., Bishop M; 3 Department of Medicine, and., Russell P; 1 National Jewish Health, Denver, Colorado., Vestal B; 1 National Jewish Health, Denver, Colorado., Cardwell J; 3 Department of Medicine, and., Markin CR; 4 Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee., Mathai SK; 3 Department of Medicine, and., Schwarz MI; 3 Department of Medicine, and., Steele MP; 3 Department of Medicine, and., Lee J; 3 Department of Medicine, and., Brown KK; 1 National Jewish Health, Denver, Colorado., Loyd JE; 4 Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee., Crapo JD; 1 National Jewish Health, Denver, Colorado.; 3 Department of Medicine, and., Silverman EK; 5 Brigham and Women's Hospital, Harvard School of Medicine, Boston, Massachusetts., Cho MH; 5 Brigham and Women's Hospital, Harvard School of Medicine, Boston, Massachusetts., James JA; 6 Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma., Guthridge JM; 6 Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma., Cogan JD; 4 Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee., Kropski JA; 4 Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee., Swigris JJ; 1 National Jewish Health, Denver, Colorado., Bair C; 1 National Jewish Health, Denver, Colorado., Kim DS; 7 Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea., Ji W; 7 Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea., Kim H; 7 Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea., Song JW; 7 Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea., Maier LA; 1 National Jewish Health, Denver, Colorado.; 2 School of Public Health.; 3 Department of Medicine, and., Pacheco KA; 1 National Jewish Health, Denver, Colorado.; 2 School of Public Health., Hirani N; 8 MRC Centre for Inflammation Research, University of Edinburgh, Edinburgh, United Kingdom.; 9 Respiratory Medicine Unit, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom., Poon AS; 9 Respiratory Medicine Unit, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom., Li F; 8 MRC Centre for Inflammation Research, University of Edinburgh, Edinburgh, United Kingdom., Jenkins RG; 10 Biomedical Research Centre, University of Nottingham, Nottingham, United Kingdom., Braybrooke R; 10 Biomedical Research Centre, University of Nottingham, Nottingham, United Kingdom., Saini G; 10 Biomedical Research Centre, University of Nottingham, Nottingham, United Kingdom., Maher TM; 11 Royal Brompton Hospital and Imperial College, London, United Kingdom., Molyneaux PL; 11 Royal Brompton Hospital and Imperial College, London, United Kingdom., Saunders P; 11 Royal Brompton Hospital and Imperial College, London, United Kingdom., Zhang Y; 12 Simmons Center for Interstitial Lung Disease, University of Pittsburgh, Pittsburgh, Pennsylvania., Gibson KF; 12 Simmons Center for Interstitial Lung Disease, University of Pittsburgh, Pittsburgh, Pennsylvania., Kass DJ; 12 Simmons Center for Interstitial Lung Disease, University of Pittsburgh, Pittsburgh, Pennsylvania., Rojas M; 12 Simmons Center for Interstitial Lung Disease, University of Pittsburgh, Pittsburgh, Pennsylvania., Sembrat J; 12 Simmons Center for Interstitial Lung Disease, University of Pittsburgh, Pittsburgh, Pennsylvania., Wolters PJ; 13 Department of Medicine, University of California, San Francisco, San Francisco, California., Collard HR; 13 Department of Medicine, University of California, San Francisco, San Francisco, California., Sundy JS; 14 Gilead Sciences, Foster City, California., O'Riordan T; 14 Gilead Sciences, Foster City, California., Strek ME; 15 Department of Medicine, University of Chicago, Chicago, Illinois., Noth I; 16 Department of Medicine, University of Virginia, Charlottesville, Virginia., Ma SF; 16 Department of Medicine, University of Virginia, Charlottesville, Virginia., Porteous MK; 17 Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania., Kreider ME; 17 Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania., Patel NB; 17 Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania., Inoue Y; 18 National Hospital Organization Kinki-Chuo Chest Medical Center, Osaka, Japan., Hirose M; 18 National Hospital Organization Kinki-Chuo Chest Medical Center, Osaka, Japan., Arai T; 18 National Hospital Organization Kinki-Chuo Chest Medical Center, Osaka, Japan., Akagawa S; 19 National Hospital Organization Tokyo National Hospital, Tokyo, Japan., Eickelberg O; 3 Department of Medicine, and.; 20 Helmholtz Zentrum München, Neuherberg, Germany., Fernandez IE; 20 Helmholtz Zentrum München, Neuherberg, Germany., Behr J; 21 University Hospital Munich, Munich, Germany., Mogulkoc N; 22 Department of Pulmonology, Ege University Hospital, Bornova, Izmir, Turkey., Corte TJ; 23 Royal Prince Alfred Hospital and University of Sydney, Sydney, Australia., Glaspole I; 24 Alfred Hospital and Monash University, Melbourne, Australia., Tomassetti S; 25 Pulmonary Medicine, GB Morgagni Hospital, Forlì, Italy., Ravaglia C; 26 Department of Diseases of the Thorax, Ospedale GB Morgagni, Forlì, Italy., Poletti V; 26 Department of Diseases of the Thorax, Ospedale GB Morgagni, Forlì, Italy., Crestani B; 27 Université Paris Diderot and Hôpital Bichat, Paris, France., Borie R; 27 Université Paris Diderot and Hôpital Bichat, Paris, France., Kannengiesser C; 27 Université Paris Diderot and Hôpital Bichat, Paris, France., Parfrey H; 28 Royal Papworth Hospital and Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom., Fiddler C; 28 Royal Papworth Hospital and Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom., Rassl D; 28 Royal Papworth Hospital and Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom., Molina-Molina M; 29 Respiratory Department, University Hospital of Bellvitge, University of Barcelona, Barcelona, Spain., Machahua C; 29 Respiratory Department, University Hospital of Bellvitge, University of Barcelona, Barcelona, Spain., Worboys AM; 29 Respiratory Department, University Hospital of Bellvitge, University of Barcelona, Barcelona, Spain., Gudmundsson G; 30 National University Hospital of Iceland, University of Iceland, Reykjavik, Iceland., Isaksson HJ; 30 National University Hospital of Iceland, University of Iceland, Reykjavik, Iceland., Lederer DJ; 31 Department of Medicine, Columbia University Irving Medical Center, New York, New York., Podolanczuk AJ; 31 Department of Medicine, Columbia University Irving Medical Center, New York, New York., Montesi SB; 32 Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Boston, Massachusetts., Bendstrup E; 33 Department of Respiratory Diseases and Allergy, Aarhus University Hospital, Aarhus, Denmark., Danchel V; 33 Department of Respiratory Diseases and Allergy, Aarhus University Hospital, Aarhus, Denmark., Selman M; 34 Instituto Nacional de Enfermedades Respiratorias 'Ismael Cosio Villegas,' México City, México., Pardo A; 35 Universidad Nacional Autónoma de México, México City, México., Henry MT; 36 Cork University Hospital and University College Cork, Cork, Ireland., Keane MP; 37 St. Vincent's University Hospital, Dublin, Ireland.; 38 School of Medicine, University College Dublin, Dublin, Ireland., Doran P; 37 St. Vincent's University Hospital, Dublin, Ireland.; 38 School of Medicine, University College Dublin, Dublin, Ireland., Vašáková M; 39 Department of Respiratory Medicine, First Faculty of Medicine Charles University and Thomayer Hospital, Prague, Czech Republic., Sterclova M; 39 Department of Respiratory Medicine, First Faculty of Medicine Charles University and Thomayer Hospital, Prague, Czech Republic., Ryerson CJ; 40 University of British Columbia, Vancouver, Canada., Wilcox PG; 40 University of British Columbia, Vancouver, Canada., Okamoto T; 3 Department of Medicine, and.; 41 Tokyo Medical and Dental University, Tokyo, Japan., Furusawa H; 3 Department of Medicine, and.; 41 Tokyo Medical and Dental University, Tokyo, Japan., Miyazaki Y; 41 Tokyo Medical and Dental University, Tokyo, Japan., Laurent G; 42 Institute for Respiratory Health and.; 43 Centre for Cell Therapy and Regenerative Medicine, School of Biomedical Sciences, The University of Western Australia, Perth, Australia., Baltic S; 42 Institute for Respiratory Health and., Prele C; 42 Institute for Respiratory Health and.; 43 Centre for Cell Therapy and Regenerative Medicine, School of Biomedical Sciences, The University of Western Australia, Perth, Australia., Moodley Y; 42 Institute for Respiratory Health and., Shea BS; 44 Department of Medicine, Warren Alpert Medical School of Brown University, Providence, Rhode Island., Ohta K; 19 National Hospital Organization Tokyo National Hospital, Tokyo, Japan., Suzukawa M; 19 National Hospital Organization Tokyo National Hospital, Tokyo, Japan., Narumoto O; 19 National Hospital Organization Tokyo National Hospital, Tokyo, Japan., Nathan SD; 45 Advanced Lung Disease and Transplant Program, Inova Fairfax Hospital, Falls Church, Virginia., Venuto DC; 45 Advanced Lung Disease and Transplant Program, Inova Fairfax Hospital, Falls Church, Virginia., Woldehanna ML; 45 Advanced Lung Disease and Transplant Program, Inova Fairfax Hospital, Falls Church, Virginia., Kokturk N; 46 Department of Pulmonary Medicine, Gazi University School of Medicine, Ankara, Turkey., de Andrade JA; 47 Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama., Luckhardt T; 47 Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama., Kulkarni T; 47 Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama., Bonella F; 48 Ruhrlandklinik, University Hospital, University of Duisburg-Essen, Essen, Germany., Donnelly SC; 49 Department of Medicine, Tallaght University Hospital, Trinity College Dublin, Dublin, Ireland., McElroy A; 49 Department of Medicine, Tallaght University Hospital, Trinity College Dublin, Dublin, Ireland., Armstong ME; 49 Department of Medicine, Tallaght University Hospital, Trinity College Dublin, Dublin, Ireland., Aranda A; 50 CardioPulmonary Reserach Center, Alliance Pulmonary Group, Guaynabo, Puerto Rico., Carbone RG; 51 Department of Internal Medicine, University of Genoa, Genoa, Italy., Puppo F; 51 Department of Internal Medicine, University of Genoa, Genoa, Italy., Beckman KB; 52 Biomedical Genomics Center, University of Minnesota; Minneapolis, Minnesota; and., Nickerson DA; 53 Northwest Genomics Center, University of Washington, Seattle, Washington., Fingerlin TE; 1 National Jewish Health, Denver, Colorado.; 2 School of Public Health.; 3 Department of Medicine, and., Schwartz DA; 1 National Jewish Health, Denver, Colorado.; 3 Department of Medicine, and.; 54 Department of Immunology, University of Colorado Denver, Denver, Colorado.

Publikováno v: American journal of respiratory and critical care medicine [Am J Respir Crit Care Med] 2019 Jul 15; Vol. 200 (2), pp. 199-208.