Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Woosuk S. Hur"'
Autor:
Nima Mazinani, Amy W. Strilchuk, James R. Baylis, Woosuk S. Hur, Wilfred A. Jefferies, Christian J. Kastrup
Publikováno v:
Research and Practice in Thrombosis and Haemostasis, Vol 4, Iss 5, Pp 823-828 (2020)
Abstract Background Amyloid precursor protein (APP) is highly expressed in platelets. APP is the precursor to amyloid beta (Aβ) peptides that accumulate in cerebral amyloid angiopathy and plaques in Alzheimer disease. APP and its metabolites interac
Externí odkaz:
https://doaj.org/article/b2e82134ca0a488889001f2b831cc902
Autor:
Oscar Negrón, Woosuk S Hur, Joni Prasad, David S Paul, Sarah E Rowe, Jay L Degen, Sara R Abrahams, Silvio Antoniak, Brian P Conlon, Wolfgang Bergmeier, Magnus Hӧӧk, Matthew J Flick
Publikováno v:
PLoS Pathogens, Vol 18, Iss 1, p e1010227 (2022)
The blood-clotting protein fibrin(ogen) plays a critical role in host defense against invading pathogens, particularly against peritoneal infection by the Gram-positive microbe Staphylococcus aureus. Here, we tested the hypothesis that direct binding
Externí odkaz:
https://doaj.org/article/1cdfdde0a1ee486a8eb41935fd614820
Autor:
Woosuk S. Hur, Katharine C. King, Yesha N. Patel, Y‐Van Nguyen, Zimu Wei, Yi Yang, Lih Jiin Juang, Jerry Leung, Christian J. Kastrup, Alisa S. Wolberg, James P. Luyendyk, Matthew J. Flick
Publikováno v:
Journal of Thrombosis and Haemostasis. 20:2873-2886
Obesity predisposes individuals to metabolic syndrome, which increases the risk of cardiovascular diseases, non-alcoholic fatty liver disease (NAFLD), and type 2 diabetes. A pathological manifestation of obesity is the activation of the coagulation s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49c5f005d3d9e9ead1d2d303860fa6c3
https://doi.org/10.1111/jth.15877
https://doi.org/10.1111/jth.15877
Autor:
Lauren G. Poole, Lauren R. Schmitt, Anthony Schulte, Dafna J. Groeneveld, Holly M. Cline, Yaqiu Sang, Woosuk S. Hur, Alisa S. Wolberg, Matthew J. Flick, Kirk C. Hansen, James P. Luyendyk
Publikováno v:
Journal of Thrombosis and Haemostasis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a6e7bc86640a4f966523af8684997f17
https://doi.org/10.1016/j.jtha.2023.04.003
https://doi.org/10.1016/j.jtha.2023.04.003
Autor:
Woosuk S. Hur, David S. Paul, Emma G. Bouck, Oscar A. Negrón, Jean-Marie Mwiza, Lauren G. Poole, Holly M. Cline-Fedewa, Emily G. Clark, Lih Jiin Juang, Jerry Leung, Christian J. Kastrup, Tatiana P. Ugarova, Alisa S. Wolberg, James P. Luyendyk, Wolfgang Bergmeier, Matthew J. Flick
Publikováno v:
Blood. 139:1374-1388
Genetic variants within the fibrinogen Aα chain encoding the αC-region commonly result in hypodysfibrinogenemia in patients. However, the (patho)physiological consequences and underlying mechanisms of such mutations remain undefined. Here, we gener
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4bc72409136dacd6973d037830ae438
https://doi.org/10.1182/blood.2021012537
https://doi.org/10.1182/blood.2021012537
Publikováno v:
Diabetes. 71
Obesity affects over 40% of the US population and predisposes individuals to metabolic syndrome, which is associated with a 50% increase in the risk of cardiovascular events. A documented clinical manifestation of obesity is a procoagulant and anti-f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e95324b78e27e0193b42e3c11e8d2c4a
https://doi.org/10.2337/db22-8-or
https://doi.org/10.2337/db22-8-or
Autor:
Lih Jiin Juang, Christian J. Kastrup, Wilfred A. Jefferies, Nima Mazinani, Woosuk S. Hur, Lonna Munro
Publikováno v:
Biochemistry. 59:4449-4455
The physiological function of amyloid β precursor protein (APP) in platelets has remained elusive. Upon platelet activation, APP localizes to the platelet surface and is proteolytically processed by proteases to release various metabolites, includin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a37d2c40bc8aea355899932bed66ec41
https://doi.org/10.1021/acs.biochem.0c00450
https://doi.org/10.1021/acs.biochem.0c00450
Autor:
Wilfred A. Jefferies, Woosuk S. Hur, Christian J. Kastrup, Amy W. Strilchuk, James R. Baylis, Nima Mazinani
Publikováno v:
Research and Practice in Thrombosis and Haemostasis
Research and Practice in Thrombosis and Haemostasis, Vol 4, Iss 5, Pp 823-828 (2020)
Research and Practice in Thrombosis and Haemostasis, Vol 4, Iss 5, Pp 823-828 (2020)
Background Amyloid precursor protein (APP) is highly expressed in platelets. APP is the precursor to amyloid beta (Aβ) peptides that accumulate in cerebral amyloid angiopathy and plaques in Alzheimer disease. APP and its metabolites interact with ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a57a0cc5edb9f73e9f532db267664be1
https://doi.org/10.1002/rth2.12375
https://doi.org/10.1002/rth2.12375
Autor:
Lih Jiin Juang, Woosuk S. Hur, Lakmali M. Silva, Amy W. Strilchuk, Brenton Francisco, Jerry Leung, Madelaine K. Robertson, Dafna J. Groeneveld, Bridget La Prairie, Elizabeth M. Chun, Andrew P. Cap, James P. Luyendyk, Joseph S. Palumbo, Pieter R. Cullis, Thomas H. Bugge, Matthew J. Flick, Christian J. Kastrup
Publikováno v:
Blood. 139(9)
Fibrinogen plays a pathologic role in multiple diseases. It contributes to thrombosis and modifies inflammatory and immune responses, supported by studies in mice expressing fibrinogen variants with altered function or with a germline fibrinogen defi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00629ecf25f73b2fbe5da75ef6536f4f
https://pubmed.ncbi.nlm.nih.gov/35238891
https://pubmed.ncbi.nlm.nih.gov/35238891
Autor:
Leeor S. Yefet, Woosuk S. Hur, Ju Hun Yeon, Sam Filipenko, Alisa S. Wolberg, Laura Ho, Nima Mazinani, James R. Byrnes, Wilfred A. Jefferies, Christian J. Kastrup, X. J. David Lu
Publikováno v:
Journal of Biological Chemistry. 294:390-396
In cerebral amyloid angiopathy (CAA) and Alzheimer's disease (AD), the amyloid β (Aβ) peptide deposits along the vascular lumen, leading to degeneration and dysfunction of surrounding tissues. Activated coagulation factor XIIIa (FXIIIa) covalently
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32d09fc027e6e38f64339947b1df42bd
https://doi.org/10.1074/jbc.ra118.005352
https://doi.org/10.1074/jbc.ra118.005352