Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Wooseok Han"'
Autor:
Matthew T. Burger, Jocelyn Holash, Richard Zang, J. Alex Aycinena, Cornelia Bellamacina, Mika Lindvall, Gisele Nishiguchi, Jiong Lan, Wooseok Han, Christopher Wilson, Joerg Trappe, Peter Drueckes, Estelle Pfister, Audrey Kauffmann, Christine Fritsch, Tiffany Tsang, Jamie Narberes, Robert Warne, Paul Feucht, Michael Doyle, Jianjun Yu, Julie Chan, Stephen Basham, Xiao-Hong Niu, Jing Lu, Yumin Dai, Tatiana Zavorotinskaya, Marjorie Ison, Christie Fanton, Joseph Castillo, Min Chen, Yingyun Wang, John L. Langowski, Pablo D. Garcia
Purpose: PIM kinases have been shown to act as oncogenes in mice, with each family member being able to drive progression of hematologic cancers. Consistent with this, we found that PIMs are highly expressed in human hematologic cancers and show that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21b7a0911566c282b44322df88773977
https://doi.org/10.1158/1078-0432.c.6522398
https://doi.org/10.1158/1078-0432.c.6522398
Autor:
Matthew T. Burger, Jocelyn Holash, Richard Zang, J. Alex Aycinena, Cornelia Bellamacina, Mika Lindvall, Gisele Nishiguchi, Jiong Lan, Wooseok Han, Christopher Wilson, Joerg Trappe, Peter Drueckes, Estelle Pfister, Audrey Kauffmann, Christine Fritsch, Tiffany Tsang, Jamie Narberes, Robert Warne, Paul Feucht, Michael Doyle, Jianjun Yu, Julie Chan, Stephen Basham, Xiao-Hong Niu, Jing Lu, Yumin Dai, Tatiana Zavorotinskaya, Marjorie Ison, Christie Fanton, Joseph Castillo, Min Chen, Yingyun Wang, John L. Langowski, Pablo D. Garcia
PDF file - 346KB, Supplementary Figure 1. Normal vs. Tumor expression of PIM kinases mRNA across 17 tissue types. Supplementary Figure 2. Comparison of LGB321 on-target activity vs. Previously described pan-PIM inhibitor. Supplementary Figure 3. KINO
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4cf370c3ede2546f0f7aab800bf1d63
https://doi.org/10.1158/1078-0432.22452158.v1
https://doi.org/10.1158/1078-0432.22452158.v1
Autor:
Ha Na Yu, Dong Hyuk Ki, Joonwoo Nam, Eun-Jung Kim, Sungeun Kim, Hunmi Choi, Jieun Kim, Jihyun Yu, Donggeon Kim, Dohyun Park, Kyeong Jin Yoon, Seongin Jo, So-Hyeon Hwang, Sang Kyun Lim, Young Sook Shin, Wooseok Han
Publikováno v:
Cancer Research. 83:515-515
Abnormal activating mutation of KRAS is frequently found in many human cancers, including pancreatic ductal adenocarcinoma (PDAC), colorectal cancer (CRC), and non-small cell lung cancer (NSCLC). KRAS activating mutations lead to hyperactivation of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::835aeae079d184130b0edfce59719d36
https://doi.org/10.1158/1538-7445.am2023-515
https://doi.org/10.1158/1538-7445.am2023-515
Autor:
Dong Hyuk Ki, Min Sung Joo, Joonwoo Nam, Hunmi Choi, Kyoungwan Seo, Eun-Jung Kim, Jiyeon Kim, Chulwon Kim, Jimmy Taiguang Jin, Wooseok Han
Publikováno v:
Cancer Research. 83:5006-5006
Abnormal expression and activation of Epidermal Growth Factor Receptor (EGFR) contribute to malignancy development, especially in non-small cell lung cancers (NSCLCs). Although the first- to third-generation EGFR small molecule inhibitors have made s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88dfb409d1a0724c7e162da0b1f48676
https://doi.org/10.1158/1538-7445.am2023-5006
https://doi.org/10.1158/1538-7445.am2023-5006
Autor:
Pablo Garcia, Gisele Nishiguchi, Wooseok Han, Mika Lindvall, Cornelia Bellamacina, Yumin Dai, Matthew Burger, John L. Langowski, Richard Zang, Zheng Chen, Gordana Atallah, Song Lin, Paul Feucht, Jiong Lan, Yu Ding, Alice Rico, Tatiana Zavorotinskaya
Publikováno v:
Journal of Medicinal Chemistry. 63:14885-14904
Overexpression of PIM 1, 2, and 3 kinases is frequently observed in many malignancies. Previously, we discovered a potent and selective pan-PIM kinase inhibitor, compound 2, currently in phase I clinical trials. In this work, we were interested in re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59a2e2a773b3d977656af5f3b13f2c0a
https://doi.org/10.1021/acs.jmedchem.0c01279
https://doi.org/10.1021/acs.jmedchem.0c01279
Autor:
Ramadevi Prathapam, Alexandra Frommlet, Jacob Shaul, Dita M. Rasper, Xiaoyu Shen, Alexey Ruzin, Sharadha Subramanian, Feng Wang, Micah Steffek, Bret Benton, Jason Vo, Steven Shia, Wooseok Han, Andreas O. Frank, Charles Wartchow, Patrick Lee, Xiaolei Ma, Fergal Casey, Hanne Merritt, Carl J. Balibar, Alun Bermingham, Elizabeth Ornelas, Tsuyoshi Uehara, Andreas Lingel, Chi-Min Ho, Barbara Chie-Leon, William S. Sawyer, Min-Kyu Cho, Sylvia Ma, Katherine R Prosen, Min Li, Christopher M. Rath, Gianfranco De Pascale
Publikováno v:
Journal of the American Chemical Society. 142:4445-4455
The lipopolysaccharide biosynthesis pathway is considered an attractive drug target against the rising threat of multi-drug-resistant Gram-negative bacteria. Here, we report two novel small-molecule inhibitors (compounds 1 and 2) of the acyltransfera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35d90e01ff06abb91a53cfa340142eb6
https://doi.org/10.1021/jacs.9b13530
https://doi.org/10.1021/jacs.9b13530
Autor:
Min Li, Micah Steffek, Wooseok Han, Chi-Min Ho, J. de Vicente, Xiaolei Ma, Yipin Lu, Charles Wartchow, Tsuyoshi Uehara, S. Ramurthy, B. Chie Leon, Steven Shia, Ramadevi Prathapam
Publikováno v:
ACS Infectious Diseases. 6:1480-1489
LpxD, acyl-ACP-dependent N-acyltransferase, is the third enzyme of lipid A biosynthesis in Gram-negative bacteria. A recent probe-based screen identified several compounds, including 6359-0284 (com...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f785576ab92c56ccf8b896579dbe2cb2
https://doi.org/10.1021/acsinfecdis.9b00127
https://doi.org/10.1021/acsinfecdis.9b00127
Autor:
Dong Hyuk Ki, Joonwoo Nam, Eunjung Kim, Hunmi Choi, Chulwon Kim, Jiyeon Kim, Jimmy Jin, Sang-Uk Kang, Wooseok Han
Publikováno v:
Cancer Research. 82:417-417
Although EGFR-targeted tyrosine kinase inhibitors (TKIs) developed over a couple of decades have made great progress in the treatment of EGFR-mutant driven NSCLC, patients are at great risk to their lives due to drug resistance caused by constantly e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a8fb1fbfb5a829d931ac99830dcaa0d1
https://doi.org/10.1158/1538-7445.am2022-417
https://doi.org/10.1158/1538-7445.am2022-417
Autor:
Xiaoyu Shen, William S. Sawyer, Micah Steffek, Wooseok Han, Tsuyoshi Uehara, Andreas O. Frank, Sharadha Subramanian, Alexey Ruzin, Feng Wang, Alexandra Frommlet, C. M. Baxter Rath, Hanne Merritt, Min Li, Alun Bermingham, Elizabeth Ornelas, Jason Vo, Fergal Casey, B. Chie-Leon, Andreas Lingel, Bret Benton, Xiaolei Ma, Steven Shia, Carl J. Balibar, G. de Pascale, Jacob Shaul, Patrick Lee, Dita M. Rasper, Min-Kyu Cho, Charles Wartchow, Sylvia Ma, Chi-Min Ho, Katherine R Prosen, Ramadevi Prathapam
The lipopolysaccharide biosynthesis pathway is considered an attractive drug target against the rising threat of multidrug-resistant Gram-negative bacteria. Here, we report two novel small-molecule inhibitors (compounds 1 and 2) of the acyltransferas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b2ae79f01d04aaef1188b455cc539e9
Autor:
Xiaolei, Ma, Ramadevi, Prathapam, Charles, Wartchow, Barbara, Chie-Leon, Chi-Min, Ho, Javier, De Vicente, Wooseok, Han, Min, Li, Yipin, Lu, Savithri, Ramurthy, Steven, Shia, Micah, Steffek, Tsuyoshi, Uehara
Publikováno v:
ACS infectious diseases. 6(6)
LpxD, acyl-ACP-dependent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::40291ff10b575db054b1f49e3044ba8d
https://pubmed.ncbi.nlm.nih.gov/31402665
https://pubmed.ncbi.nlm.nih.gov/31402665