Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Woong Y Hwang"'
Publikováno v:
eLife, Vol 11 (2022)
Wnt signaling is essential for many aspects of embryonic development including the formation of the primary embryonic axis. In addition, excessive Wnt signaling drives multiple diseases including cancer, highlighting its importance for disease pathog
Externí odkaz:
https://doaj.org/article/d933d1a8959a4002b249ff633eca47b2
Autor:
Woong Y Hwang, Yanfang Fu, Deepak Reyon, Morgan L Maeder, Prakriti Kaini, Jeffry D Sander, J Keith Joung, Randall T Peterson, Jing-Ruey Joanna Yeh
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e68708 (2013)
We have previously reported a simple and customizable CRISPR (clustered regularly interspaced short palindromic repeats) RNA-guided Cas9 nuclease (RGN) system that can be used to efficiently and robustly introduce somatic indel mutations in endogenou
Externí odkaz:
https://doaj.org/article/ac7dbb56bb564ab4a308baa536e6c2a3
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e30406 (2012)
Impairments in mitochondria and transcription are important factors in the pathogenesis of Huntington disease (HD), a neurodegenerative disease caused by a polyglutamine expansion in the huntingtin protein. This study investigated the effect of diffe
Externí odkaz:
https://doaj.org/article/cc8f61cb38c944069671a4285f929b47
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
Frog model organisms have been appreciated for their utility in exploring physiological phenomena for nearly a century. Now, a vibrant community of biologists that utilize this model organism has poised Xenopus to serve as a high throughput vertebrat
Externí odkaz:
https://doaj.org/article/cd7b9488562c46cd862bd080345dd80d
Autor:
Woong Y. Hwang, June Criscione, Maneeshi S. Prasad, Jonathan Marquez, Martín I. García-Castro, Mustafa K. Khokha, Emily K Mis, Rebekah M. Charney
Publikováno v:
J Clin Invest
Multipass membrane proteins have a myriad of functions, including transduction of cell-cell signals, ion transport, and photoreception. Insertion of these proteins into the membrane depends on the endoplasmic reticulum (ER) membrane protein complex (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09b7ca132574e8266de79ab8900744d1
https://doi.org/10.1172/jci129308
https://doi.org/10.1172/jci129308
Publikováno v:
eLife. 11
Wnt signaling is essential for many aspects of embryonic development including the formation of the primary embryonic axis. In addition, excessive Wnt signaling drives multiple diseases including cancer, highlighting its importance for disease pathog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee21aa0c5139ee21861d8587e9d3d517
https://pubmed.ncbi.nlm.nih.gov/36300792
https://pubmed.ncbi.nlm.nih.gov/36300792
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
Frontiers in Physiology
Frontiers in Physiology
Frog model organisms have been appreciated for their utility in exploring physiological phenomena for nearly a century. Now, a vibrant community of biologists that utilize this model organism has poised Xenopus to serve as a high throughput vertebrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7a9528d0cb4d3489f631c8e20fea9e8
Autor:
Masaaki Yoshigi, Youngnam N. Jin, Shao En Ong, Steven A. Carr, Peter J. Schlueter, Jing-Ruey J. Yeh, Monica Schenone, Pui-ying Lam, Randall T. Peterson, Shan Jin, Woong Y. Hwang, Nathalie Jurisch-Yaksi, Christina R. Hartigan
Publikováno v:
Nature chemical biology. 14(9)
Primordial germ cells (PGCs) form during early embryogenesis with a supply of maternal mRNAs that contain shorter poly(A) tails. How translation of maternal mRNAs is regulated during PGC development remains elusive. Here we describe a small-molecule
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5518c2f2548bf062864405be3518a26
https://pubmed.ncbi.nlm.nih.gov/29988066
https://pubmed.ncbi.nlm.nih.gov/29988066
Publikováno v:
Methods. 69:76-84
The transcription activator-like effector (TALE) nucleases, or TALENs, are customizable restriction enzymes that may be used to induce mutations at nearly any investigator-specified DNA sequence in zebrafish. The DNA-binding specificities of TALENs a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13d8b2e7a8c3c4309a9c35d1996d1035
https://doi.org/10.1016/j.ymeth.2014.04.009
https://doi.org/10.1016/j.ymeth.2014.04.009