Zobrazeno 1 - 10
of 837
pro vyhledávání: '"Woong‐Yang Park"'
Autor:
Eun Seop Seo, Ji Won Lee, Jinyeong Lim, Sunghwan Shin, Hee Won Cho, Hee Young Ju, Keon Hee Yoo, Ki Woong Sung, Woong-Yang Park
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Germline genetic context may play a significant role in the development and evolution of cancer, particularly in childhood cancers such as neuroblastoma. This study investigates the role of putatively functional germline variants in neurobla
Externí odkaz:
https://doaj.org/article/28c3edba1fd644be8dd969ae407fc9fc
Autor:
Ji-Yeon Kim, Kyunghee Park, Woong-Yang Park, Jin Seok Ahn, Young-Hyuck Im, Jeong Eon Lee, Seok Won Kim, Seok Jin Nam, Jonghan Yu, Yeon Hee Park
Publikováno v:
npj Breast Cancer, Vol 10, Iss 1, Pp 1-11 (2024)
Abstract Genomic analysis of structural variants(SVs) in breast cancer (BC) patients has been conducted, but the relationship between genomic alterations and BC prognosis remains unclear. We performed RNA sequencing of 297 early BC fresh-frozen tissu
Externí odkaz:
https://doaj.org/article/8da5c32858644291988200f623ec5425
Autor:
Sang Hoon Kim, Bo Ryeong Lee, Sung-Min Kim, Sungsik Kim, Min-seok Kim, Jaehyun Kim, Inkyu Lee, Hee-Soo Kim, Gi-Hoon Nam, In-San Kim, Kyuyoung Song, Yoonjoo Choi, Dong-Sup Lee, Woong-Yang Park
Publikováno v:
Experimental and Molecular Medicine, Vol 56, Iss 6, Pp 1461-1471 (2024)
Abstract Neoantigens are ideal targets for cancer immunotherapy because they are expressed de novo in tumor tissue but not in healthy tissue and are therefore recognized as foreign by the immune system. Advances in next-generation sequencing and bioi
Externí odkaz:
https://doaj.org/article/3a9c03b77b79413f8e2c53e95af98f71
Autor:
Woong-Yang Park, Jaeyoung Kim, Hong-Hee Won, Chang-Nam Son, Ki Won Moon, Sang‑Hyuk Jung, Hyunsue Do, Yonghyun Nam, Jae-Seung Yun, Dokyoon Kim
Publikováno v:
RMD Open, Vol 10, Iss 4 (2024)
Objective Recent studies have reported that gout is associated with a risk of cardiovascular disease (CVD) later in life. However, the predictive value of genetic predisposition to gout combined with lifestyle habits for CVD risk remains unclear. Thi
Externí odkaz:
https://doaj.org/article/45db78efe473499582d74a4c5f5e6dab
Autor:
Chamlee Cho, Beomsu Kim, Dan Say Kim, Mi Yeong Hwang, Injeong Shim, Minku Song, Yeong Chan Lee, Sang-Hyuk Jung, Sung Kweon Cho, Woong-Yang Park, Woojae Myung, Bong-Jo Kim, Ron Do, Hyon K. Choi, Tony R. Merriman, Young Jin Kim, Hong-Hee Won
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Hyperuricemia is an essential causal risk factor for gout and is associated with cardiometabolic diseases. Given the limited contribution of East Asian ancestry to genome-wide association studies of serum urate, the genetic architecture of s
Externí odkaz:
https://doaj.org/article/c397e0e4e3324b75a714a797657f8e2d
Autor:
Sang-Hyuk Jung, Young Chan Lee, Manu Shivakumar, Jaeyoung Kim, Jae-Seung Yun, Woong-Yang Park, Hong-Hee Won, Penn Medicine Biobank, Dokyoon Kim
Publikováno v:
BMC Medicine, Vol 22, Iss 1, Pp 1-14 (2024)
Abstract Background Previous studies have shown that lifestyle/environmental factors could accelerate the development of age-related hearing loss (ARHL). However, there has not yet been a study investigating the joint association among genetics, life
Externí odkaz:
https://doaj.org/article/171e5c6d78ae457abb05035dc2b6ec89
Autor:
Young Chan Lee, Sang-Hyuk Jung, Manu Shivakumar, Soojin Cha, Woong-Yang Park, Hong-Hee Won, Young-Gyu Eun, Penn Medicine Biobank, Dokyoon Kim
Publikováno v:
BMC Medicine, Vol 22, Iss 1, Pp 1-13 (2024)
Abstract Background Numerous observational studies have highlighted associations of genetic predisposition of head and neck squamous cell carcinoma (HNSCC) with diverse risk factors, but these findings are constrained by design limitations of observa
Externí odkaz:
https://doaj.org/article/1ae348504cf743f89ce320ee4fcb2717
Autor:
Doeon Gu, Jinyeong Lim, Kyung Yeon Han, In-Ho Seo, Jae Hwan Jee, Soo Jin Cho, Yoon Ho Choi, Sung Chul Choi, Jang Hyun Koh, Jin-Young Lee, Mira Kang, Dong-Hyuk Jung, Woong-Yang Park
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
Abnormalities in glucose metabolism that precede the onset of type 2 diabetes (T2D) activate immune cells, leading to elevated inflammatory factors and chronic inflammation. However, no single-cell RNA sequencing (scRNA-seq) studies have characterize
Externí odkaz:
https://doaj.org/article/cad700f070474b3684a4146e254307d4
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Clinical decision support systems (CDSSs) play a critical role in enhancing the efficiency of mental health care delivery and promoting patient engagement. Transdiagnostic approaches that utilize raw psychological and biological data enable
Externí odkaz:
https://doaj.org/article/3e27884a7bac42b19ec7e3e31e2e7985
Autor:
Junseok Jeon, Kyungho Lee, Hye Ryoun Jang, Kyeong Eun Yang, Cheol-Jung Lee, Hyeonju Ahn, Woong-Yang Park, Jung Eun Lee, Ghee Young Kwon, Yoon-Goo Kim, Wooseong Huh
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Excessive activation of poly (ADP-ribose) polymerase (PARP) contributes to ischemic acute kidney injury (AKI). PARP inhibition has been shown to be beneficial in renal ischemia–reperfusion injury (IRI) in the early phase, but its role in t
Externí odkaz:
https://doaj.org/article/48c62f13c01841e9b262761a9b812550