Phenotypic drug screen uncovers the metabolic GCH1/BH4 pathway as key regulator of EGFR/KRAS-mediated neuropathic pain and lung cancer

Autor: Cronin, SJF, Rao, S, Tejada, MA, Turnes, BL, Licht-Mayer, S, Omura, T, Brenneis, C, Jacobs, E, Barrett, L, Latremoliere, A, Andrews, N, Channon, KM, Latini, A, Arvanites, AC, Davidow, LS, Costigan, M, Rubin, LL, Penninger, JM, Woolf, CJ

Publikováno v: Sci Transl Med

Increased tetrahydrobiopterin (BH4) generated in injured sensory neurons contributes to increased pain sensitivity and its persistence. GTP cyclohydrolase 1 (GCH1) is the rate-limiting enzyme in the de novo BH4 synthetic pathway, and human single-nuc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9d8614e10712abe782046934285b3b5
https://doi.org/10.1126/scitranslmed.abj1531

Robust Axonal Regeneration Occurs in the Injured CAST/Ei Mouse CNS

Autor: Omura, T, Omura, K, Tedeschi, A, Riva, P, Painter, MW, Rojas, L, Martin, J, Lisi, V, Huebner, EA, Latremoliere, A, Yin, Y, Barrett, LB, Singh, B, Lee, S, Crisman, T, Gao, F, Li, S, Kapur, K, Geschwind, DH, Kosik, KS, Coppola, G, He, Z, Carmichael, ST, Benowitz, LI, Costigan, M, Woolf, CJ

Publikováno v: Omura, T; Omura, K; Tedeschi, A; Riva, P; Painter, MW; Rojas, L; et al.(2014). Robust Axonal Regeneration Occurs in the Injured CAST/Ei Mouse CNS. Neuron. doi: 10.1016/j.neuron.2015.05.005. UCLA: Retrieved from: http://www.escholarship.org/uc/item/5f9010t8

© 2015 Elsevier Inc. Axon regeneration in the CNS requires reactivating injured neurons' intrinsic growth state and enabling growth in an inhibitory environment. Using an inbred mouse neuronal phenotypic screen, we find that CAST/Ei mouse adult dors

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::44c7d6f16fa0a19dbfadd579aac9a04a
http://www.escholarship.org/uc/item/5f9010t8

CLP1 links tRNA metabolism to progressive motor neuron loss

Autor: Hanada T, Weitzer S, Mair B, Bernreuther C, Wainger BJ, Ichida J, Hanada R, Orthofer M, Cronin SJ, Komnenovic V, Minis A, Sato F, Mimata H, Yoshimura A, Tamir I, Rainer J, Kofler R, Yaron A, Eggan KC, Woolf CJ, Glatzel M, Herbst R, Martinez J, Penninger JM

Publikováno v: Nature.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=erc_________::1b9d0cb420c011583660bc654042ae34

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