Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Woojung Shin"'
Autor:
Soyoun Min, Nam Than, Yong Cheol Shin, Grace Hu, Woojung Shin, Yoko M. Ambrosini, Hyun Jung Kim
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Here, we report a pathomimetic Leaky Gut Chip that recapitulates increased epithelial permeability and intestinal inflammation to assess probiotic intervention as live biotherapeutics. We leveraged a mechanodynamic human gut-on-a-chip (Gut C
Externí odkaz:
https://doaj.org/article/dbf8e70eea404d169e65e2c62ed6487d
Publikováno v:
iScience, Vol 25, Iss 12, Pp 105521- (2022)
Summary: The human gut-on-a-chip has demonstrated in vivo-relevant cellular fidelity and physiological functions of Caco-2 intestinal epithelium compared to its static cultures. However, transcriptomic dynamics that controls the morphogenic and mecha
Externí odkaz:
https://doaj.org/article/43bb57fd4689456bb5ff92f98db1d683
Autor:
Woojung Shin, Hyun Jung Kim
Publikováno v:
Frontiers in Medical Technology, Vol 4 (2022)
Externí odkaz:
https://doaj.org/article/e209437e31db4f97ab2bc0be1907942d
Publikováno v:
Gut Microbes, Vol 11, Iss 3, Pp 581-586 (2020)
A microengineered human gut-on-a-chip has demonstrated intestinal physiology, three-dimensional (3D) epithelial morphogenesis, and longitudinal host-microbiome interactions in vitro. The modular accessibility and modularity of the microphysiological
Externí odkaz:
https://doaj.org/article/744e4ba644454f33826d56b9863ac4ba
Publikováno v:
iScience, Vol 15, Iss , Pp 391-406 (2019)
Summary: We leveraged a human gut-on-a-chip (Gut Chip) microdevice that enables independent control of fluid flow and mechanical deformations to explore how physical cues and morphogen gradients influence intestinal morphogenesis. Both human intestin
Externí odkaz:
https://doaj.org/article/2eee8055588346b5b9ddd8498bd45bdd
Autor:
Woojung Shin, Alexander Wu, Soyoun Min, Yong Cheol Shin, R. Y. Declan Fleming, S. Gail Eckhardt, Hyun Jung Kim
Publikováno v:
iScience, Vol 23, Iss 8, Pp 101372- (2020)
Summary: In a conventional culture of three-dimensional human intestinal organoids, extracellular matrix hydrogel has been used to provide a physical space for the growth and morphogenesis of organoids in the presence of exogenous morphogens such as
Externí odkaz:
https://doaj.org/article/d796b1ac37cb424ab58e2473ad1322ef
Autor:
Yoko M Ambrosini, Yejin Park, Albert E Jergens, Woojung Shin, Soyoun Min, Todd Atherly, Dana C Borcherding, Jinah Jang, Karin Allenspach, Jonathan P Mochel, Hyun Jung Kim
Publikováno v:
PLoS ONE, Vol 15, Iss 4, p e0231423 (2020)
Recent advances in canine intestinal organoids have expanded the option for building a better in vitro model to investigate translational science of intestinal physiology and pathology between humans and animals. However, the three-dimensional geomet
Externí odkaz:
https://doaj.org/article/c14410ce6d1946329cca211b53c56cdd
Autor:
Amir Bein, Woojung Shin, Sasan Jalili-Firoozinezhad, Min Hee Park, Alexandra Sontheimer-Phelps, Alessio Tovaglieri, Angeliki Chalkiadaki, Hyun Jung Kim, Donald E. Ingber
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 5, Iss 4, Pp 659-668 (2018)
Microfluidic organ-on-a-chip models of human intestine have been developed and used to study intestinal physiology and pathophysiology. In this article, we review this field and describe how microfluidic Intestine Chips offer new capabilities not pos
Externí odkaz:
https://doaj.org/article/1649e018d954403a9bd7246603660a8c
Autor:
Woojung Shin, Alexander Wu, Miles W. Massidda, Charles Foster, Newin Thomas, Dong-Woo Lee, Hong Koh, Youngwon Ju, Joohoon Kim, Hyun Jung Kim
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 7 (2019)
The majority of human gut microbiome is comprised of obligate anaerobic bacteria that exert essential metabolic functions in the human colon. These anaerobic gut bacteria constantly crosstalk with the colonic epithelium in a mucosal anoxic-oxic inter
Externí odkaz:
https://doaj.org/article/9a39566cad0e47ccbc3782b014a98ea9
Autor:
Yong Cheol Shin, Woojung Shin, Domin Koh, Alexander Wu, Yoko M. Ambrosini, Soyoun Min, S. Gail Eckhardt, R. Y. Declan Fleming, Seung Kim, Sowon Park, Hong Koh, Tae Kyung Yoo, Hyun Jung Kim
Publikováno v:
Micromachines, Vol 11, Iss 7, p 663 (2020)
The regeneration of the mucosal interface of the human intestine is critical in the host–gut microbiome crosstalk associated with gastrointestinal diseases. The biopsy-derived intestinal organoids provide genetic information of patients with physio
Externí odkaz:
https://doaj.org/article/1f0717a4f6e84b20a7c83d0a152d77fd