Zobrazeno 1 - 10
of 125
pro vyhledávání: '"Woojin S. Kim"'
Autor:
Jasmin Galper, Giorgia Mori, Gordon McDonald, Diba Ahmadi Rastegar, Russell Pickford, Simon J. G. Lewis, Glenda M. Halliday, Woojin S. Kim, Nicolas Dzamko
Publikováno v:
npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-9 (2024)
Abstract Identifying biological factors which contribute to the clinical progression of heterogeneous motor and non-motor phenotypes in Parkinson’s disease may help to better understand the disease process. Several lipid-related genetic risk factor
Externí odkaz:
https://doaj.org/article/d5f223abd06a454fa2a51735d65b6a53
Autor:
Kellen Cristina da Cruz Rodrigues, Seung Chan Kim, Aaron Aykut Uner, Zhi-Shuai Hou, Jennie Young, Clara Campolim, Ahmet Aydogan, Brendon Chung, Anthony Choi, Won-Mo Yang, Woojin S. Kim, Vincent Prevot, Barbara J. Caldarone, Hyon Lee, Young-Bum Kim
Publikováno v:
Molecular Metabolism, Vol 84, Iss , Pp 101941- (2024)
Objective: Low-density lipoprotein receptor-related protein-1 (LRP1) regulates energy homeostasis, blood–brain barrier integrity, and metabolic signaling in the brain. Deficiency of LRP1 in inhibitory gamma-aminobutyric acid (GABA)ergic neurons cau
Externí odkaz:
https://doaj.org/article/e55f3e4f47234ed2a72826ad4425a226
Autor:
Priscilla Youssef, Laura Hughes, Woojin S. Kim, Glenda M. Halliday, Simon J. G. Lewis, Antony Cooper, Nicolas Dzamko
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Objective biomarkers for Parkinson’s Disease (PD) could aid early and specific diagnosis, effective monitoring of disease progression, and improved design and interpretation of clinical trials. Although alpha-synuclein remains a biomarker
Externí odkaz:
https://doaj.org/article/1fb73d2a0cf2476ba2fe850027c13533
Autor:
Adahir Labrador-Garrido, Siying Zhong, Laura Hughes, Shikara Keshiya, Woojin S. Kim, Glenda M. Halliday, Nicolas Dzamko
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
IntroductionHeterozygous mutations in GBA1, which encodes the lysosomal hydrolase glucocerebrosidase (GCase), are a common risk factor for the neurodegenerative movement disorder Parkinson's disease (PD). Consequently, therapeutic options targeting t
Externí odkaz:
https://doaj.org/article/c89347aae76540ea9933273a0178d93c
Autor:
Benedikt Frieg, James A. Geraets, Timo Strohäker, Christian Dienemann, Panagiota Mavroeidi, Byung Chul Jung, Woojin S. Kim, Seung-Jae Lee, Maria Xilouri, Markus Zweckstetter, Gunnar F. Schröder
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-10 (2022)
Quaternary structure of α-synuclein fibrils characterized from human patients with Parkinson’s disease and Multiple System Atrophy modulates seeding in mouse primary oligodendroglial cultures.
Externí odkaz:
https://doaj.org/article/d4d40573e183445fa4fa87a88105ffd0
Autor:
Emil Gregersen, Cristine Betzer, Woojin S. Kim, Gergo Kovacs, Lasse Reimer, Glenda M. Halliday, Steffen Thiel, Poul Henning Jensen
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-10 (2021)
Abstract Background Synucleinopathies are characterized by neurodegeneration and deposition of the presynaptic protein α-synuclein in pathological protein inclusions. Growing evidence suggests the complement system not only has physiological functio
Externí odkaz:
https://doaj.org/article/2f4014a2d45d4b40865571ea11a96759
Autor:
Timo Strohäker, Byung Chul Jung, Shu-Hao Liou, Claudio O. Fernandez, Dietmar Riedel, Stefan Becker, Glenda M. Halliday, Marina Bennati, Woojin S. Kim, Seung-Jae Lee, Markus Zweckstetter
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Parkinson’s disease (PD) and Multiple System Atrophy (MSA) are characterized by the pathological accumulation of α-synuclein. Here the authors employ fluorescent probes, electron microscopy and NMR spectroscopy to study the properties of α-synucl
Externí odkaz:
https://doaj.org/article/645030a3102e4d44bda780706743ff0d
Publikováno v:
Biomolecules, Vol 12, Iss 11, p 1597 (2022)
Genetic alterations in the LRRK2 gene, encoding leucine-rich repeat kinase 2, are a common risk factor for Parkinson’s disease. How LRRK2 alterations lead to cell pathology is an area of ongoing investigation, however, multiple lines of evidence su
Externí odkaz:
https://doaj.org/article/aaf4e7c9759c48efba28371f5c81191f
Autor:
Rachel H. Tan, Yue Yang, Woojin S. Kim, Carol Dobson-Stone, John B. Kwok, Matthew C. Kiernan, Glenda M. Halliday
Publikováno v:
Acta Neuropathologica Communications, Vol 5, Iss 1, Pp 1-7 (2017)
Abstract The identification of the TAR DNA-binding protein 43 (TDP-43) as the ubiquitinated cytoplasmic inclusions in frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS) confirmed that these two diseases share similar mec
Externí odkaz:
https://doaj.org/article/7cde02c9a4dd433a81e5e80e29a4a474
Autor:
Theresa N. T. Dang, Carol Dobson-Stone, Elias N. Glaros, Woojin S. Kim, Marianne Hallupp, Lauren Bartley, Olivier Piguet, John R. Hodges, Glenda M. Halliday, Kay L. Double, Peter R. Schofield, Peter J. Crouch, John B. J. Kwok
Publikováno v:
Disease Models & Mechanisms, Vol 6, Iss 5, Pp 1198-1204 (2013)
SUMMARY Frontotemporal dementia (FTD) is associated with motor neurone disease (FTD-MND), corticobasal syndrome (CBS) and progressive supranuclear palsy syndrome (PSPS). Together, this group of disorders constitutes a major cause of young-onset demen
Externí odkaz:
https://doaj.org/article/652819affd724e67a4c39f977e1db999