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Flavones provide resistance to DUX4-induced toxicity via an mTor-independent mechanism.

Autor: Cohen J; Department of Genetics, Yale School of Medicine, New Haven, CT, 06510, USA., Huang S; Department of Genetics, Yale School of Medicine, New Haven, CT, 06510, USA., Koczwara KE; Department of Genetics, Yale School of Medicine, New Haven, CT, 06510, USA., Woods KT; Wellstone Muscular Dystrophy Program, Department of Neurology, University of Massachusetts Chan Medical School, Worcester, MA, USA.; Li Weibo Institute for Rare Disease Research University of Massachusetts Chan Medical School, Worcester, MA, USA., Ho V; Department of Genetics, Yale School of Medicine, New Haven, CT, 06510, USA., Woodman KG; Department of Genetics, Yale School of Medicine, New Haven, CT, 06510, USA., Arbiser JL; United Derm Partners/Metroderm, Atlanta, GA, 30322, USA., Daman K; Wellstone Muscular Dystrophy Program, Department of Neurology, University of Massachusetts Chan Medical School, Worcester, MA, USA.; Li Weibo Institute for Rare Disease Research University of Massachusetts Chan Medical School, Worcester, MA, USA., Lek M; Department of Genetics, Yale School of Medicine, New Haven, CT, 06510, USA., Emerson CP Jr; Wellstone Muscular Dystrophy Program, Department of Neurology, University of Massachusetts Chan Medical School, Worcester, MA, USA.; Li Weibo Institute for Rare Disease Research University of Massachusetts Chan Medical School, Worcester, MA, USA., DeSimone AM; Department of Genetics, Yale School of Medicine, New Haven, CT, 06510, USA. Alec_DeSimone@alumni.brown.edu.; Modalis Therapeutics, Waltham, MA, USA. Alec_DeSimone@alumni.brown.edu.

Publikováno v: Cell death & disease [Cell Death Dis] 2023 Nov 16; Vol. 14 (11), pp. 749. Date of Electronic Publication: 2023 Nov 16.