Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Woods, Wannamaker"'
Autor:
George Ku, John Pollard, Woods Wannamaker, John C. R. Randle, Peter Weber, Pamella J. Ford, Paul S. Charifson, Ursula A. Germann, Robert J. Davies, Mark N. Namchuk, Caroline Decker, Keisuke Kuida
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 321:509-516
(S)-1-((S)-2-{[1-(4-amino-3-chloro-phenyl)-methanoyl]-amino}-3,3-dimethyl-butanoyl)-pyrrolidine-2-carboxylic acid ((2R,3S)-2-ethoxy-5-oxo-tetrahydro-furan-3-yl)-amide (VX-765) is an orally absorbed prodrug of (S)-3-({1-[(S)-1-((S)-2-{[1-(4-amino-3-ch
Autor:
David Messersmith, Harmon J. Zuccola, Thomas Hoock, Sudipta Mahajan, Christopher Town, M. Woods Wannamaker, Luke Oh, Jian Wang, James J. Black, Bin Fan, Pamela McCarthy, Francesco G. Salituro, Mark N. Namchuk, Christopher L Brummel, Valerie Marone, Warren Dorsch, Randy S. Bethiel, Mark W. Ledeboer, Edmund Harrington, Summer Halas, Dina Shlyakter, Lora Swenson, Cochran John E, Youssef L. Bennani, Arthur Rugg, David Howe, Albert C. Pierce, Shannon Dean, Marina Penney, Hui Huang, Tiansheng Wang, Gabriel Martinez-Botella, James K. Hogan, Ananthsrinivas Chakilam, Shengkai Liao, Michael J. Arnost, Kumkum Saxena, Luc J. Farmer, Scott A. Raybuck, Shi-Kai Tian, Dylan Jacobs, Leena Laitinen, Raymond J. Winquist
Publikováno v:
Journal of medicinal chemistry. 58(18)
While several therapeutic options exist, the need for more effective, safe, and convenient treatment for a variety of autoimmune diseases persists. Targeting the Janus tyrosine kinases (JAKs), which play essential roles in cell signaling responses an
Autor:
Marc Jacobs, Christopher Bral, Youssef L. Bennani, Jianglin Liang, John P. Duffy, Tiansheng Wang, Brian Ledford, Michael J. Boyd, Wenxin Gu, Randal Byrn, Min Jiang, Christine Memmott, Azin Nezami, Ioana Davies, Joshua R. Leeman, Yuegang Zhang, Hamilton B. Bennett, Warren Dorsch, Katrina L. Jackson, Upul K. Bandarage, William P. Taylor, Mark W. Ledeboer, Dylan Jacobs, Francesco G. Salituro, Kennedy Joseph M, Huai Gao, Nti-Addae Kwame Wiredu, Michael P. Clark, Francois Maltais, Emanuele Perola, Murcko Mark A, Deng Hongbo, M. Woods Wannamaker, Ursula A. Germann, Alice Tsai, Rene Rijnbrand, Luc J. Farmer, Colleen F. McNeil, Randy S. Bethiel, Paul S. Charifson, John J. Court, Jones Steven
Publikováno v:
Journal of medicinal chemistry. 57(15)
In our effort to develop agents for the treatment of influenza, a phenotypic screening approach utilizing a cell protection assay identified a series of azaindole based inhibitors of the cap-snatching function of the PB2 subunit of the influenza A vi
Autor:
M. Woods Wannamaker, Albert Padwa
Publikováno v:
Tetrahedron. 47:6139-6156
A study of the cycloaddition behavior of several arylsulfonyl substituted alkynes with 2-diazopropane has been carried out. These activated acetylenes react to give 3H-pyrazoles which extrude nitrogen on photolysis to produce cyclopropenes in high yi
Autor:
M. Woods Wannamaker, Albert Padwa
Publikováno v:
Tetrahedron. 46:1145-1162
A study of the cycloaddition behavior of several trimethylsilyl substituted alkynes with 2-diazopropane and diazomethane has been carried out. Aryl or alkyl ethynyl sulfones react to give 5-sulfonyl substituted 3H-pyrazoles which extrude nitrogen on
Autor:
Woods, Wannamaker, Robert, Davies, Mark, Namchuk, John, Pollard, Pamella, Ford, George, Ku, Caroline, Decker, Paul, Charifson, Peter, Weber, Ursula A, Germann, Keisuke, Kuida, John C R, Randle
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 321(2)
(S)-1-((S)-2-{[1-(4-amino-3-chloro-phenyl)-methanoyl]-amino}-3,3-dimethyl-butanoyl)-pyrrolidine-2-carboxylic acid ((2R,3S)-2-ethoxy-5-oxo-tetrahydro-furan-3-yl)-amide (VX-765) is an orally absorbed prodrug of (S)-3-({1-[(S)-1-((S)-2-{[1-(4-amino-3-ch
Publikováno v:
Journal of the American Chemical Society. 115:8885-8885
Autor:
M. Woods Wannamaker, Albert Padwa
Publikováno v:
Tetrahedron Letters. 27:5817-5820
Sulfonyl substituted cyclopropenes react with a variety of alkyl lithium reagents to give disubstituted cyclopropenes in good yield.
Publikováno v:
The Journal of Organic Chemistry. 52:4760-4767
Preparation de la [dimethyl-3,3 trimethylsilyl-2] cyclopropene-1yl p-tolyl sulfone a partir du diazo-2 propane et de la p-tolyl trimethylsilylethynyl sulfone
Publikováno v:
The Journal of Organic Chemistry. 54:1635-1642