APOE-related risk of mild cognitive impairment and dementia for prevention trials: An analysis of four cohorts

Autor: Qian, Jing, Wolters, Frank J., Beiser, Alexa, Haan, Mary, Ikram, M. Arfan, Karlawish, Jason, Langbaum, Jessica B., Neuhaus, John M., Reiman, Eric M., Roberts, J. Scott, Seshadri, Sudha, Tariot, Pierre N., Woods, Beth McCarty, Betensky, Rebecca A., Blacker, Deborah

Background With the onset of prevention trials for individuals at high risk for Alzheimer disease, there is increasing need for accurate risk prediction to inform study design and enrollment, but available risk estimates are limited. We developed ris

Externí odkaz: http://hdl.handle.net/10150/623943
http://arizona.openrepository.com/arizona/handle/10150/623943

APOE-related risk of mild cognitive impairment and dementia for prevention trials: An analysis of four cohorts.

Autor: Qian J; Department of Biostatistics and Epidemiology, University of Massachusetts Amherst, Amherst, Massachusetts, United States of America., Wolters FJ; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands., Beiser A; Department of Neurology, Boston University Medical School, Boston, Massachusetts, United States of America.; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America., Haan M; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, United States of America., Ikram MA; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands., Karlawish J; Department of Medicine, University of Pennsylvania Medical School, Philadelphia, Pennsylvania, United States of America., Langbaum JB; Banner Alzheimer's Institute, Phoenix, Arizona, United States of America., Neuhaus JM; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, United States of America., Reiman EM; Banner Alzheimer's Institute, Phoenix, Arizona, United States of America.; Department of Psychiatry, University of Arizona College of Medicine, Phoenix, Arizona, United States of America.; Arizona State University-Banner Neurodegenerative Disease Research Center, Tempe, Arizona, United States of America.; Neurogenomics Division, Translational Genomics Research Institute, Phoenix, Arizona, United States of America., Roberts JS; Department of Health Behavior & Health Education, University of Michigan School of Public Health, Ann Arbor, Michigan, United States of America., Seshadri S; Department of Neurology, Boston University Medical School, Boston, Massachusetts, United States of America., Tariot PN; Banner Alzheimer's Institute, Phoenix, Arizona, United States of America.; Department of Psychiatry, University of Arizona College of Medicine, Phoenix, Arizona, United States of America., Woods BM; Department of Medicine, University of Pennsylvania Medical School, Philadelphia, Pennsylvania, United States of America., Betensky RA; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America., Blacker D; Department of Psychiatry, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts, United States of America.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America.

Publikováno v: PLoS medicine [PLoS Med] 2017 Mar 21; Vol. 14 (3), pp. e1002254. Date of Electronic Publication: 2017 Mar 21 (Print Publication: 2017).