Targeting Mycobacterium tuberculosis Persistence through Inhibition of the Trehalose Catalytic Shift.

Autor: Kalera K; Department of Chemistry and Biochemistry, Central Michigan University, Mount Pleasant, Michigan 48859, United States.; Biochemistry, Cell, and Molecular Biology Program, Central Michigan University, Mount Pleasant, Michigan 48859, United States., Liu R; Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, United States., Lim J; Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, United States., Pathirage R; Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, Nebraska 68198, United States., Swanson DH; Department of Chemistry and Biochemistry, Central Michigan University, Mount Pleasant, Michigan 48859, United States., Johnson UG; Department of Chemistry and Biochemistry, Central Michigan University, Mount Pleasant, Michigan 48859, United States.; Biochemistry, Cell, and Molecular Biology Program, Central Michigan University, Mount Pleasant, Michigan 48859, United States., Stothard AI; Department of Chemistry and Biochemistry, Central Michigan University, Mount Pleasant, Michigan 48859, United States., Lee JJ; Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, United States., Poston AW; Department of Chemistry and Biochemistry, Central Michigan University, Mount Pleasant, Michigan 48859, United States., Woodruff PJ; Department of Chemistry, University of Southern Maine, Portland, Maine 04104, United States., Ronning DR; Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, Nebraska 68198, United States., Eoh H; Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, United States., Swarts BM; Department of Chemistry and Biochemistry, Central Michigan University, Mount Pleasant, Michigan 48859, United States.; Biochemistry, Cell, and Molecular Biology Program, Central Michigan University, Mount Pleasant, Michigan 48859, United States.

Publikováno v: ACS infectious diseases [ACS Infect Dis] 2024 Apr 12; Vol. 10 (4), pp. 1391-1404. Date of Electronic Publication: 2024 Mar 14.

Degradation-resistant trehalose analogues block utilization of trehalose by hypervirulent Clostridioides difficile.

Autor: Danielson ND; Department of Chemistry and Biochemistry, Central Michigan University, Mount Pleasant, MI, USA. ben.swarts@cmich.edu., Collins J, Stothard AI, Dong QQ, Kalera K, Woodruff PJ, DeBosch BJ, Britton RA, Swarts BM

Publikováno v: Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2019 Apr 23; Vol. 55 (34), pp. 5009-5012.

Chemoenzymatic Synthesis of Trehalosamine, an Aminoglycoside Antibiotic and Precursor to Mycobacterial Imaging Probes.

Autor: Groenevelt JM; Department of Chemistry and Biochemistry , Central Michigan University , Mount Pleasant , Michigan 48859 , United States., Meints LM; Department of Chemistry and Biochemistry , Central Michigan University , Mount Pleasant , Michigan 48859 , United States., Stothard AI; Department of Chemistry and Biochemistry , Central Michigan University , Mount Pleasant , Michigan 48859 , United States., Poston AW; Department of Chemistry and Biochemistry , Central Michigan University , Mount Pleasant , Michigan 48859 , United States., Fiolek TJ; Department of Chemistry and Biochemistry , Central Michigan University , Mount Pleasant , Michigan 48859 , United States., Finocchietti DH; Department of Chemistry , University of Southern Maine , Portland , Maine 04104 , United States., Mulholand VM; Department of Chemistry , University of Southern Maine , Portland , Maine 04104 , United States., Woodruff PJ; Department of Chemistry , University of Southern Maine , Portland , Maine 04104 , United States., Swarts BM; Department of Chemistry and Biochemistry , Central Michigan University , Mount Pleasant , Michigan 48859 , United States.

Publikováno v: The Journal of organic chemistry [J Org Chem] 2018 Aug 03; Vol. 83 (15), pp. 8662-8667. Date of Electronic Publication: 2018 Jul 23.

Tailoring Trehalose for Biomedical and Biotechnological Applications.

Autor: O'Neill MK; Department of Chemistry and Biochemistry, Central Michigan University, Mount Pleasant, MI 48859, USA., Piligian BF; Department of Chemistry and Biochemistry, Central Michigan University, Mount Pleasant, MI 48859, USA., Olson CD; Department of Chemistry and Biochemistry, Central Michigan University, Mount Pleasant, MI 48859, USA., Woodruff PJ; Department of Chemistry, University of Southern Maine, Portland, ME, USA., Swarts BM; Department of Chemistry and Biochemistry, Central Michigan University, Mount Pleasant, MI 48859, USA.

Publikováno v: Pure and applied chemistry. Chimie pure et appliquee [Pure Appl Chem] 2017 Sep; Vol. 89 (9), pp. 1223-1249. Date of Electronic Publication: 2017 Jan 11.

Deoxyfluoro-d-trehalose (FDTre) analogues as potential PET probes for imaging mycobacterial infection.

Autor: Rundell SR; Department of Chemistry and Biochemistry, Central Michigan University, Mount Pleasant, MI 48859, USA. ben.swarts@cmich.edu., Wagar ZL, Meints LM, Olson CD, O'Neill MK, Piligian BF, Poston AW, Hood RJ, Woodruff PJ, Swarts BM

Publikováno v: Organic & biomolecular chemistry [Org Biomol Chem] 2016 Sep 28; Vol. 14 (36), pp. 8598-609. Date of Electronic Publication: 2016 Aug 25.