Bleaching of mouse rods: microspectrophotometry and suction-electrode recording

Autor: Nymark, S, Frederiksen, R, Woodruff, M L, Cornwall, M C, Fain, G L

Publikováno v: The Journal of physiology. 590(10)

When a substantial fraction of rhodopsin in a rod photoreceptor is exposed to bright light, the rod is desensitized by a process known as bleaching adaptation. Experiments on isolated photoreceptors in amphibians have revealed many of the features of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::7e75678d98391d4f8e1e664f3eb369e3
https://pubmed.ncbi.nlm.nih.gov/22787167

GAP-independent termination of photoreceptor light response by excess gamma subunit of the cGMP-phosphodiesterase

Autor: Tsang, S H, Woodruff, M L, Chen, C K, Yamashita, C Y, Cilluffo, M C, Rao, A L, Farber, D B, Fain, G L

Publikováno v: Tsang, S H; Woodruff, M L; Chen, C K; Yamashita, C Y; Cilluffo, M C; Rao, A L; et al.(2006). GAP-independent termination of photoreceptor light response by excess gamma subunit of the cGMP-phosphodiesterase. Journal of Neuroscience, 26(17), 4472-4480. UCLA: Retrieved from: http://www.escholarship.org/uc/item/68r3c2jj

We have generated a mouse with rod photoreceptors overexpressing the gamma inhibitory subunit ( PDE6 gamma) of the photoreceptor G-protein effector cGMP phosphodiesterase ( PDE6). PDE6 gamma overexpression decreases the rate of rise of the rod respon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::b11322ed136e59adfc74b461197f0e96
http://www.escholarship.org/uc/item/68r3c2jj

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Removal of phosphorylation sites of γ subunit of phosphodiesterase 6 alters rod light response.

Autor: Tsang, S. H., Woodruff, M. L., Janisch, Kerstin M., Cilluffo, M. C., Farber, D. B., Fain, G. L.

Publikováno v: Journal of Physiology; Mar2007, Vol. 579 Issue 2, p303-312, 10p

Ca2+-dependent changes in cyclic GMP levels are not correlated with opening and closing of the light-dependent permeability of toad photoreceptors.

Autor: Woodruff, M L, Fain, G L

Publikováno v: The Journal of General Physiology; October 1982, Vol. 80 Issue: 4 p537-555, 19p