Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Woodrow Burchett"'
Autor:
Sangwoo Ryu, Woodrow Burchett, Sam Zhang, Seyed Mohamad Sadegh Modaresi, Juliana Agudelo Areiza, Emily Kaye, Fabian Christoph Fischer, Angela L. Slitt
Publikováno v:
Toxics, Vol 12, Iss 4, p 253 (2024)
Per- and polyfluoroalkyl substances (PFAS) are a diverse group of fluorinated compounds which have yet to undergo comprehensive investigation regarding potential adverse health effects and bioaccumulative properties. With long half-lives and accumula
Externí odkaz:
https://doaj.org/article/06fc9dc5efc2469aa362326c5d8c8583
Autor:
Amanda L. Webb, Adam Dugan, Woodrow Burchett, Kelly Barnett, Nishi Patel, Scott Morehead, Mark Silverberg, Christopher Doty, Brian Adkins, Lauren Falvo
Publikováno v:
Western Journal of Emergency Medicine, Vol 16, Iss 6, Pp 961-964 (2015)
Introduction: Medical educators in recent years have been using social media for more penetrance to technologically-savvy learners. The utility of using Twitter for curriculum content delivery has not been studied. We sought to determine if partici
Externí odkaz:
https://doaj.org/article/385d744d44d7486b8c631da35e2eba5b
Autor:
Angela C. Doran, Alyssa L. Dantonio, Gabrielle M. Gualtieri, Amanda Balesano, Connor Landers, Woodrow Burchett, Theunis C. Goosen, R. Scott Obach
Publikováno v:
Drug Metabolism and Disposition. 50:1272-1286
Cytochrome P450 reaction phenotyping to determine the fraction of metabolism values (f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11d75f4c59170879ccb0e19a61073e75
https://doi.org/10.1124/dmd.122.000883
https://doi.org/10.1124/dmd.122.000883
Autor:
Angela C. Doran, Woodrow Burchett, Connor Landers, Gabrielle M. Gualtieri, Amanda Balesano, Heather Eng, Alyssa L Dantonio, Theunis C. Goosen, R. Scott Obach
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals.
The utility of chemical inhibitors in cytochrome P450 (CYP) reaction phenotyping is highly dependent on their selectivity and potency for their target CYP isoforms. In the present study, seventeen inhibitors of CYP1A2, 2B6, 2C8, 2C9, 2C19, 2D6, and 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85fdb54fca7319cb247bf9771b45d19f
https://pubmed.ncbi.nlm.nih.gov/35777846
https://pubmed.ncbi.nlm.nih.gov/35777846
Publikováno v:
Biopharmaceutics & Drug Disposition. 42:234-241
The blood-to-plasma ratio (Rb ) is an important property of drug candidates. Rb is applied widely in drug discovery to convert plasma pharmacokinetic parameters to the respective parameters in blood and to develop in vitro-in vivo correlations. Some
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c663d7fa3ca5f306850b75043fbb0f6
https://doi.org/10.1002/bdd.2265
https://doi.org/10.1002/bdd.2265
Autor:
Shibin Mathew, George Chang, Christopher Keefer, Shinji Yamazaki, Jian Lin, Samantha Jordan, Woodrow Burchett, Christine C. Orozco, David A. Tess, Nathaniel Woody, Rhys M. Jones, Li Di
Publikováno v:
Journal of pharmaceutical sciences. 110(4)
Volume of distribution at steady state (Vss) is an important pharmacokinetic parameter of a drug candidate. In this study, Vss prediction accuracy was evaluated by using: (1) seven methods for rat with 56 compounds, (2) four methods for human with 12
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc076581837f9da92c421f3c57955317
https://pubmed.ncbi.nlm.nih.gov/33338491
https://pubmed.ncbi.nlm.nih.gov/33338491
Autor:
Christopher Keefer, Jonathan J. Novak, Woodrow Burchett, Li Di, Gregory S. Steeno, George Chang, Sangwoo Ryu, Keith Riccardi, David A. Tess, Roshan Patel, Karen Atkinson
Publikováno v:
Drug Metabolism and Pharmacokinetics. 35:S65-S66
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fea13990aca0a760d73b7603ae71d610
https://doi.org/10.1016/j.dmpk.2020.04.143
https://doi.org/10.1016/j.dmpk.2020.04.143
Autor:
Woodrow Burchett, Karen Atkinson, Li Di, Gregory S. Steeno, George Chang, Jonathan J. Novak, Christopher Keefer, David A. Tess, Sangwoo Ryu, Keith Riccardi, Roshan Patel
Publikováno v:
Journal of pharmaceutical sciences. 109(2)
Binding to various tissues and species is frequently assessed in drug discovery and development to support safety and efficacy studies. To reduce time, cost, and labor requirements for binding experiments, we conducted a large comparison study to eva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d54301d2b209e5fbc7504becbdf911d
https://pubmed.ncbi.nlm.nih.gov/31704191
https://pubmed.ncbi.nlm.nih.gov/31704191
Publikováno v:
Journal of pharmaceutical sciences. 108(11)
Significant advances have been made over the years to accurately measure plasma protein binding (PPB) of highly bound compounds. However, because of perceived uncertainty based on historical suboptimal methods and limitation of radiochemical purity o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e6af20a7704c49a305e239605f40102
https://pubmed.ncbi.nlm.nih.gov/31419399
https://pubmed.ncbi.nlm.nih.gov/31419399
Autor:
David L. Mobley, Gregory S. Steeno, Mingjun Yang, Xinjun Hou, Qingyi Yang, Woodrow Burchett, Shuai Liu
Publikováno v:
J Comput Chem
Journal of computational chemistry, vol 41, iss 3
Journal of computational chemistry, vol 41, iss 3
Pairwise-based methods such as the free energy perturbation (FEP) method have been widely deployed to compute the binding free energy differences between two similar host-guest complexes. The calculated pairwise free energy difference is either direc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::403246f73b9a82ca769f6d6989883abb
https://pubmed.ncbi.nlm.nih.gov/31721260
https://pubmed.ncbi.nlm.nih.gov/31721260