Safety, Tolerability, and Pharmacokinetics of an Oral Small Molecule Inhibitor of IL-17A (LY3509754): A Phase I Randomized Placebo-Controlled Study.

Autor: Datta-Mannan A; Eli Lilly and Company, Indianapolis, Indiana, USA., Regev A; Eli Lilly and Company, Indianapolis, Indiana, USA., Coutant DE; Eli Lilly and Company, Indianapolis, Indiana, USA., Dropsey AJ; Eli Lilly and Company, Indianapolis, Indiana, USA., Foster J; Eli Lilly and Company, Bracknell, Berkshire, UK., Jones S; Eli Lilly and Company, Indianapolis, Indiana, USA., Poorbaugh J; Eli Lilly and Company, Indianapolis, Indiana, USA., Schmitz C; Eli Lilly and Company, San Diego, California, USA., Wang E; Eli Lilly and Company, Indianapolis, Indiana, USA., Woodman ME; Eli Lilly and Company, Indianapolis, Indiana, USA.

Publikováno v: Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2024 May; Vol. 115 (5), pp. 1152-1161. Date of Electronic Publication: 2024 Jan 31.

Utilization of peptide phage display to investigate hotspots on IL-17A and what it means for drug discovery.

Autor: Ting JP; Department of protein Engineering, Eli Lilly Biotechnology Center, San Diego, California, United States of America., Tung F; Department of structural Biology, Discovery Chemistry Research and Technologies, Lilly Biotechnology Center, Eli Lilly and Company, San Diego, California, United States of America., Antonysamy S; Department of structural Biology, Discovery Chemistry Research and Technologies, Lilly Biotechnology Center, Eli Lilly and Company, San Diego, California, United States of America., Wasserman S; Department of structural Biology, Discovery Chemistry Research and Technologies, Eli Lilly and Company, Advanced Photon Source, Argonne, Illinois, United States of America., Jones SB; Lilly Research Laboratories, Indianapolis, Indiana, United States of America., Zhang FF; Department of structural Biology, Discovery Chemistry Research and Technologies, Lilly Biotechnology Center, Eli Lilly and Company, San Diego, California, United States of America., Espada A; Centro de Investigación Lilly, Alcobendas, Spain., Broughton H; Centro de Investigación Lilly, Alcobendas, Spain., Chalmers MJ; Lilly Research Laboratories, Indianapolis, Indiana, United States of America., Woodman ME; Lilly Research Laboratories, Indianapolis, Indiana, United States of America., Bina HA; Lilly Research Laboratories, Indianapolis, Indiana, United States of America., Dodge JA; Lilly Research Laboratories, Indianapolis, Indiana, United States of America., Benach J; Department of structural Biology, Discovery Chemistry Research and Technologies, Eli Lilly and Company, Advanced Photon Source, Argonne, Illinois, United States of America., Zhang A; Department of structural Biology, Discovery Chemistry Research and Technologies, Lilly Biotechnology Center, Eli Lilly and Company, San Diego, California, United States of America., Groshong C; Department of structural Biology, Discovery Chemistry Research and Technologies, Lilly Biotechnology Center, Eli Lilly and Company, San Diego, California, United States of America., Manglicmot D; Department of structural Biology, Discovery Chemistry Research and Technologies, Lilly Biotechnology Center, Eli Lilly and Company, San Diego, California, United States of America., Russell M; Department of structural Biology, Discovery Chemistry Research and Technologies, Lilly Biotechnology Center, Eli Lilly and Company, San Diego, California, United States of America., Afshar S; Department of protein Engineering, Eli Lilly Biotechnology Center, San Diego, California, United States of America.

Publikováno v: PloS one [PLoS One] 2018 Jan 12; Vol. 13 (1), pp. e0190850. Date of Electronic Publication: 2018 Jan 12 (Print Publication: 2018).

Human platelets efficiently kill IgG-opsonized E. coli.

Autor: Riaz AH; Department of Medical Microbiology & Immunology, University of Toledo College of Medicine, Toledo, OH 43614, USA., Tasma BE, Woodman ME, Wooten RM, Worth RG

Publikováno v: FEMS immunology and medical microbiology [FEMS Immunol Med Microbiol] 2012 Jun; Vol. 65 (1), pp. 78-83. Date of Electronic Publication: 2012 Mar 20.

Interleukin-10 mediated autoregulation of murine B-1 B-cells and its role in Borrelia hermsii infection.

Autor: Sindhava V; Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky College of Medicine, Lexington, Kentucky, United States of America., Woodman ME, Stevenson B, Bondada S

Publikováno v: PloS one [PLoS One] 2010 Jul 06; Vol. 5 (7), pp. e11445. Date of Electronic Publication: 2010 Jul 06.

Production of outer surface protein A by Borrelia burgdorferi during transmission from infected mammals to feeding ticks is insufficient to trigger OspA seroconversion.

Autor: Woodman ME; Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky College of Medicine, Lexington, KY 40536-0298, USA., Cooley AE, Stevenson B

Publikováno v: FEMS immunology and medical microbiology [FEMS Immunol Med Microbiol] 2008 Nov; Vol. 54 (2), pp. 277-82. Date of Electronic Publication: 2008 Sep 10.