Reducing lung function decline in patients with idiopathic pulmonary fibrosis: potential of nintedanib

Autor: Woodcock HV, Molyneaux PL, Maher TM

Publikováno v: Drug Design, Development and Therapy, Vol 2013, Iss default, Pp 503-510 (2013)

Hannah V Woodcock,1,2 Philip L Molyneaux,1,3 Toby M Maher1–31Interstitial Lung Disease Unit, Royal Brompton Hospital, 2Centre for Respiratory Research, University College London, 3National Heart and Lung Institute, Imperial College London, London,

Externí odkaz: https://doaj.org/article/5c5afe9609da44609a8d9b3314e35360

mTORC1 amplifies the ATF4-dependent de novo serine-glycine pathway to supply glycine during TGF-β 1 -induced collagen biosynthesis.

Autor: Selvarajah B; Centre for Inflammation and Tissue Repair, UCL Respiratory, Rayne Building, University College London, London WC1E 6JF, UK., Azuelos I; Centre for Inflammation and Tissue Repair, UCL Respiratory, Rayne Building, University College London, London WC1E 6JF, UK., Platé M; Centre for Inflammation and Tissue Repair, UCL Respiratory, Rayne Building, University College London, London WC1E 6JF, UK., Guillotin D; Centre for Inflammation and Tissue Repair, UCL Respiratory, Rayne Building, University College London, London WC1E 6JF, UK., Forty EJ; Centre for Inflammation and Tissue Repair, UCL Respiratory, Rayne Building, University College London, London WC1E 6JF, UK., Contento G; Centre for Inflammation and Tissue Repair, UCL Respiratory, Rayne Building, University College London, London WC1E 6JF, UK., Woodcock HV; Centre for Inflammation and Tissue Repair, UCL Respiratory, Rayne Building, University College London, London WC1E 6JF, UK., Redding M; Centre for Inflammation and Tissue Repair, UCL Respiratory, Rayne Building, University College London, London WC1E 6JF, UK., Taylor A; Fibrosis Discovery Performance Unit, Respiratory Therapy Area, Medicines Research Centre, GlaxoSmithKline R&D, Stevenage SG1 2NY, UK., Brunori G; GlaxoSmithKline, David Jack Centre for R&D, Park Road, Ware, Hertfordshire, SG12 0DP, UK., Durrenberger PF; Centre for Inflammation and Tissue Repair, UCL Respiratory, Rayne Building, University College London, London WC1E 6JF, UK., Ronzoni R; Centre for Respiratory Biology, UCL Respiratory, Rayne Building, University College London, London WC1E 6JF, UK., Blanchard AD; Fibrosis Discovery Performance Unit, Respiratory Therapy Area, Medicines Research Centre, GlaxoSmithKline R&D, Stevenage SG1 2NY, UK., Mercer PF; Centre for Inflammation and Tissue Repair, UCL Respiratory, Rayne Building, University College London, London WC1E 6JF, UK., Anastasiou D; Cancer Metabolism Laboratory, Francis Crick Institute, London NW1 1AT, UK., Chambers RC; Centre for Inflammation and Tissue Repair, UCL Respiratory, Rayne Building, University College London, London WC1E 6JF, UK. r.chambers@ucl.ac.uk.

Publikováno v: Science signaling [Sci Signal] 2019 May 21; Vol. 12 (582). Date of Electronic Publication: 2019 May 21.

The mTORC1/4E-BP1 axis represents a critical signaling node during fibrogenesis.

Autor: Woodcock HV; Centre for Inflammation and Tissue Repair, UCL Respiratory, Rayne Building, University College London, London, WC1E 6JF, UK., Eley JD; Centre for Inflammation and Tissue Repair, UCL Respiratory, Rayne Building, University College London, London, WC1E 6JF, UK., Guillotin D; Centre for Inflammation and Tissue Repair, UCL Respiratory, Rayne Building, University College London, London, WC1E 6JF, UK., Platé M; Centre for Inflammation and Tissue Repair, UCL Respiratory, Rayne Building, University College London, London, WC1E 6JF, UK., Nanthakumar CB; Fibrosis Discovery Performance Unit, Respiratory Therapy Area, Medicines Research Centre, GlaxoSmithKline R&D, Gunnels Wood Road, Stevenage, SG1 2NY, UK., Martufi M; Target Sciences, Medicines Research Centre, GlaxoSmithKline R&D, Gunnels Wood Road, Stevenage, SG1 2NY, UK., Peace S; Fibrosis Discovery Performance Unit, Respiratory Therapy Area, Medicines Research Centre, GlaxoSmithKline R&D, Gunnels Wood Road, Stevenage, SG1 2NY, UK., Joberty G; Cellzome, a GSK Company, Meyershofstrasse 1, 69117, Heidelberg, Germany., Poeckel D; Cellzome, a GSK Company, Meyershofstrasse 1, 69117, Heidelberg, Germany., Good RB; Fibrosis Discovery Performance Unit, Respiratory Therapy Area, Medicines Research Centre, GlaxoSmithKline R&D, Gunnels Wood Road, Stevenage, SG1 2NY, UK., Taylor AR; Fibrosis Discovery Performance Unit, Respiratory Therapy Area, Medicines Research Centre, GlaxoSmithKline R&D, Gunnels Wood Road, Stevenage, SG1 2NY, UK., Zinn N; Cellzome, a GSK Company, Meyershofstrasse 1, 69117, Heidelberg, Germany., Redding M; Centre for Inflammation and Tissue Repair, UCL Respiratory, Rayne Building, University College London, London, WC1E 6JF, UK., Forty EJ; Centre for Inflammation and Tissue Repair, UCL Respiratory, Rayne Building, University College London, London, WC1E 6JF, UK., Hynds RE; CRUK Lung Cancer Centre of Excellence, UCL Cancer Institute, University College London, London, WC1E 6DD, UK.; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, NW1 1AT, UK., Swanton C; CRUK Lung Cancer Centre of Excellence, UCL Cancer Institute, University College London, London, WC1E 6DD, UK.; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, NW1 1AT, UK., Karsdal M; Nordic Bioscience, Herlev, 2730, Denmark., Maher TM; Fibrosis Research Group, Inflammation, Repair & Development Section, NHLI, Imperial College, London, SW3 6LY, UK., Fisher A; Newcastle Fibrosis Research Group, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, UK., Bergamini G; Cellzome, a GSK Company, Meyershofstrasse 1, 69117, Heidelberg, Germany., Marshall RP; Fibrosis Discovery Performance Unit, Respiratory Therapy Area, Medicines Research Centre, GlaxoSmithKline R&D, Gunnels Wood Road, Stevenage, SG1 2NY, UK., Blanchard AD; Fibrosis Discovery Performance Unit, Respiratory Therapy Area, Medicines Research Centre, GlaxoSmithKline R&D, Gunnels Wood Road, Stevenage, SG1 2NY, UK., Mercer PF; Centre for Inflammation and Tissue Repair, UCL Respiratory, Rayne Building, University College London, London, WC1E 6JF, UK., Chambers RC; Centre for Inflammation and Tissue Repair, UCL Respiratory, Rayne Building, University College London, London, WC1E 6JF, UK. r.chambers@ucl.ac.uk.

Publikováno v: Nature communications [Nat Commun] 2019 Jan 02; Vol. 10 (1), pp. 6. Date of Electronic Publication: 2019 Jan 02.

A structurally distinct TGF-β mimic from an intestinal helminth parasite potently induces regulatory T cells.

Autor: Johnston CJC; Institute of Infection and Immunology Research and Centre for Immunity, Infection and Evolution, School of Biological Sciences, University of Edinburgh, Edinburgh, EH9 3JT, UK.; Department of Clinical Surgery, University of Edinburgh, Edinburgh, EH16 4TJ, UK., Smyth DJ; Institute of Infection and Immunology Research and Centre for Immunity, Infection and Evolution, School of Biological Sciences, University of Edinburgh, Edinburgh, EH9 3JT, UK.; Wellcome Centre for Molecular Parasitology, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, G12 8TA, UK., Kodali RB; Department of Structural Biology, University of Pittsburgh School of Medicine, 3501 Fifth Aveue, Pittsburgh, PA, 15260, USA., White MPJ; Wellcome Centre for Molecular Parasitology, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, G12 8TA, UK., Harcus Y; Institute of Infection and Immunology Research and Centre for Immunity, Infection and Evolution, School of Biological Sciences, University of Edinburgh, Edinburgh, EH9 3JT, UK., Filbey KJ; Institute of Infection and Immunology Research and Centre for Immunity, Infection and Evolution, School of Biological Sciences, University of Edinburgh, Edinburgh, EH9 3JT, UK.; Malaghan Institute of Medical Research, PO Box 7080, Wellington, 6242, New Zealand., Hewitson JP; Institute of Infection and Immunology Research and Centre for Immunity, Infection and Evolution, School of Biological Sciences, University of Edinburgh, Edinburgh, EH9 3JT, UK.; Department of Biology, University of York, York, YO10 5DD, UK., Hinck CS; Department of Structural Biology, University of Pittsburgh School of Medicine, 3501 Fifth Aveue, Pittsburgh, PA, 15260, USA., Ivens A; Institute of Infection and Immunology Research and Centre for Immunity, Infection and Evolution, School of Biological Sciences, University of Edinburgh, Edinburgh, EH9 3JT, UK., Kemter AM; Institute of Infection and Immunology Research and Centre for Immunity, Infection and Evolution, School of Biological Sciences, University of Edinburgh, Edinburgh, EH9 3JT, UK., Kildemoes AO; Institute of Infection and Immunology Research and Centre for Immunity, Infection and Evolution, School of Biological Sciences, University of Edinburgh, Edinburgh, EH9 3JT, UK.; Section for Parasitology and Aquatic Diseases, Department of Veterinary Disease Biology, University of Copenhagen, Copenhagen, DK-1870, Denmark., Le Bihan T; Institute of Infection and Immunology Research and Centre for Immunity, Infection and Evolution, School of Biological Sciences, University of Edinburgh, Edinburgh, EH9 3JT, UK., Soares DC; MRC Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, EH16 4TJ, UK., Anderton SM; MRC Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, EH16 4TJ, UK., Brenn T; Department of Pathology, Western General Hospital, University of Edinburgh, Edinburgh, EH16 4TJ, UK., Wigmore SJ; Department of Clinical Surgery, University of Edinburgh, Edinburgh, EH16 4TJ, UK., Woodcock HV; Centre for Inflammation and Tissue Repair, UCL Respiratory, Rayne Institute, University College London, London, WC1E 6JF, UK., Chambers RC; Centre for Inflammation and Tissue Repair, UCL Respiratory, Rayne Institute, University College London, London, WC1E 6JF, UK., Hinck AP; Department of Structural Biology, University of Pittsburgh School of Medicine, 3501 Fifth Aveue, Pittsburgh, PA, 15260, USA., McSorley HJ; Institute of Infection and Immunology Research and Centre for Immunity, Infection and Evolution, School of Biological Sciences, University of Edinburgh, Edinburgh, EH9 3JT, UK.; MRC Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, EH16 4TJ, UK., Maizels RM; Wellcome Centre for Molecular Parasitology, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, G12 8TA, UK. rick.maizels@glasgow.ac.uk.

Publikováno v: Nature communications [Nat Commun] 2017 Nov 23; Vol. 8 (1), pp. 1741. Date of Electronic Publication: 2017 Nov 23.

Exploration of a potent PI3 kinase/mTOR inhibitor as a novel anti-fibrotic agent in IPF.

Autor: Mercer PF; Centre for Inflammation and Tissue Repair, UCL Respiratory, Rayne Institute, University College London, London, UK., Woodcock HV; Centre for Inflammation and Tissue Repair, UCL Respiratory, Rayne Institute, University College London, London, UK., Eley JD; Centre for Inflammation and Tissue Repair, UCL Respiratory, Rayne Institute, University College London, London, UK., Platé M; Centre for Inflammation and Tissue Repair, UCL Respiratory, Rayne Institute, University College London, London, UK., Sulikowski MG; Centre for Inflammation and Tissue Repair, UCL Respiratory, Rayne Institute, University College London, London, UK., Durrenberger PF; Centre for Inflammation and Tissue Repair, UCL Respiratory, Rayne Institute, University College London, London, UK., Franklin L; Centre for Inflammation and Tissue Repair, UCL Respiratory, Rayne Institute, University College London, London, UK., Nanthakumar CB; Department of Fibrosis DPU, Respiratory TA, GlaxoSmithKline, Stevenage, UK., Man Y; Department of Fibrosis DPU, Respiratory TA, GlaxoSmithKline, Stevenage, UK., Genovese F; Nordic Bioscience, Herlev, Denmark., McAnulty RJ; Centre for Inflammation and Tissue Repair, UCL Respiratory, Rayne Institute, University College London, London, UK., Yang S; Department of Fibrosis DPU, Respiratory TA, GlaxoSmithKline, Stevenage, UK., Maher TM; NIHR Respiratory Biomedical Research Unit, Royal Brompton Hospital, London, UK., Nicholson AG; NIHR Respiratory Biomedical Research Unit, Royal Brompton Hospital, London, UK., Blanchard AD; Department of Fibrosis DPU, Respiratory TA, GlaxoSmithKline, Stevenage, UK., Marshall RP; Department of Fibrosis DPU, Respiratory TA, GlaxoSmithKline, Stevenage, UK., Lukey PT; Department of Fibrosis DPU, Respiratory TA, GlaxoSmithKline, Stevenage, UK., Chambers RC; Centre for Inflammation and Tissue Repair, UCL Respiratory, Rayne Institute, University College London, London, UK.

Publikováno v: Thorax [Thorax] 2016 Aug; Vol. 71 (8), pp. 701-11. Date of Electronic Publication: 2016 Apr 21.