Genomic plasticity and rapid host switching can promote the evolution of generalism: a case study in the zoonotic pathogen Campylobacter

Autor: Woodcock, DJ, Krusche, P, Strachan, NJC, Forbes, KJ, Cohan, FM, Méric, G, Sheppard, SK

Publikováno v: Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)

Horizontal gene transfer accelerates bacterial adaptation to novel environments, allowing selection to act on genes that have evolved in multiple genetic backgrounds. This can lead to ecological specialization. However, little is known about how zoon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::50cb229afc6dcfd2c7b43cdea23e1903
http://europepmc.org/articles/PMC5575054

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Genomic evolution shapes prostate cancer disease type.

Autor: Woodcock DJ; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK; Nuffield Department of Medicine, University of Oxford, Oxford, UK; Big Data Institute, University of Oxford, Oxford, UK., Sahli A; Nuffield Department of Medicine, University of Oxford, Oxford, UK; Big Data Institute, University of Oxford, Oxford, UK., Teslo R; Big Data Institute, University of Oxford, Oxford, UK., Bhandari V; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada., Gruber AJ; Nuffield Department of Medicine, University of Oxford, Oxford, UK; Big Data Institute, University of Oxford, Oxford, UK; Department of Biology, University of Konstanz, Konstanz, Germany., Ziubroniewicz A; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK; Big Data Institute, University of Oxford, Oxford, UK., Gundem G; Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, UK; Memorial Sloan-Kettering Cancer Center, New York, NY, USA., Xu Y; Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, UK., Butler A; Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, UK., Anokian E; The Institute of Cancer Research, London, UK., Pope BJ; Melbourne Bioinformatics, University of Melbourne, Melbourne, VIC, Australia; Department of Clinical Pathology, The University of Melbourne, Melbourne, VIC, Australia; Department of Medicine, Central Clinical School, Monash University, Melbourne, VIC, Australia., Jung CH; Melbourne Bioinformatics, University of Melbourne, Melbourne, VIC, Australia., Tarabichi M; The Francis Crick Institute, London, UK; Institute of Interdisciplinary Research (IRIBHM), Universite Libre de Bruxelles, Brussels, Belgium., Dentro SC; Nuffield Department of Medicine, University of Oxford, Oxford, UK; Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, UK; The Francis Crick Institute, London, UK., Farmery JHR; Statistics and Computational Biology Laboratory, Cancer Research UK Cambridge Institute, Cambridge, UK., Van Loo P; The Francis Crick Institute, London, UK; Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Warren AY; Department of Histopathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Gnanapragasam V; Cambridge Urology Translational Research and Clinical Trials Office, Addenbrooke's Hospital, Cambridge, UK; Division of Urology, Department of Surgery, University of Cambridge, Cambridge, UK; Department of Urology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Hamdy FC; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK., Bova GS; Prostate Cancer Research Center, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland; Tays Cancer Center, Tampere University Hospital, Tampere, Finland., Foster CS; HCA Laboratories, London, UK., Neal DE; Uro-Oncology Research Group, Cancer Research UK Cambridge Institute, Cambridge, UK; Department of Surgical Oncology, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK., Lu YJ; Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, London, UK., Kote-Jarai Z; The Institute of Cancer Research, London, UK., Fraser M; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada., Bristow RG; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada; Division of Cancer Sciences, Faculty of Biology, Health and Medicine, University of Manchester, Manchester, UK; The Christie NHS Foundation Trust, Manchester, UK; CRUK Manchester Institute, University of Manchester, Manchester, UK; Manchester Cancer Research Centre, University of Manchester, Manchester, UK., Boutros PC; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada; Departments of Human Genetics and Urology, University of California, Los Angeles, Los Angeles, CA, USA; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA, USA., Costello AJ; Department of Surgery, University of Melbourne, Melbourne, VIC, Australia; Department of Urology, Royal Melbourne Hospital, Melbourne, VIC, Australia; Victorian Comprehensive Cancer Centre, Parkville, VIC, Australia., Corcoran NM; Department of Surgery, University of Melbourne, Melbourne, VIC, Australia; Department of Urology, Royal Melbourne Hospital, Melbourne, VIC, Australia; Victorian Comprehensive Cancer Centre, Parkville, VIC, Australia., Hovens CM; Department of Surgery, University of Melbourne, Melbourne, VIC, Australia; Department of Urology, Royal Melbourne Hospital, Melbourne, VIC, Australia; Victorian Comprehensive Cancer Centre, Parkville, VIC, Australia., Massie CE; Uro-Oncology Research Group, Cancer Research UK Cambridge Institute, Cambridge, UK; Early Detection Programme and Urological Malignancies Programme, Cancer Research UK Cambridge Centre, Department of Oncology, University of Cambridge, Cambridge, UK., Lynch AG; Statistics and Computational Biology Laboratory, Cancer Research UK Cambridge Institute, Cambridge, UK; School of Medicine/School of Mathematics and Statistics, University of St Andrews, St Andrews, UK., Brewer DS; Norwich Medical School, University of East Anglia, Norwich, UK; Earlham Institute, Norwich, UK. Electronic address: d.brewer@uea.ac.uk., Eeles RA; The Institute of Cancer Research, London, UK; Royal Marsden NHS Foundation Trust, London, UK. Electronic address: ros.eeles@icr.ac.uk., Cooper CS; The Institute of Cancer Research, London, UK; Norwich Medical School, University of East Anglia, Norwich, UK. Electronic address: colin.cooper@uea.ac.uk., Wedge DC; Nuffield Department of Medicine, University of Oxford, Oxford, UK; Big Data Institute, University of Oxford, Oxford, UK; Manchester Cancer Research Centre, University of Manchester, Manchester, UK; Oxford NIHR Biomedical Research Centre, Oxford, UK; Manchester NIHR Biomedical Research Centre, Manchester, UK. Electronic address: david.wedge@manchester.ac.uk.

Publikováno v: Cell genomics [Cell Genom] 2024 Mar 13; Vol. 4 (3), pp. 100511. Date of Electronic Publication: 2024 Feb 29.

Aligning germline and somatic mutations in prostate cancer. Are genetics changing practice?

Autor: Cussenot O; Centre de Recherche sur les Pathologies Prostatiques et Urologiques (CeRePP), Paris, France.; GRC 5 Predictive Onco-Urology, Sorbonne University, Paris, France.; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK., Cancel-Tassin G; Centre de Recherche sur les Pathologies Prostatiques et Urologiques (CeRePP), Paris, France.; GRC 5 Predictive Onco-Urology, Sorbonne University, Paris, France., Rao SR; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK., Woodcock DJ; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK., Lamb AD; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK., Mills IG; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK., Hamdy FC; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.

Publikováno v: BJU international [BJU Int] 2023 Nov; Vol. 132 (5), pp. 472-484. Date of Electronic Publication: 2023 Jul 27.