REVERBa couples the circadian clock to hepatic glucocorticoid action

Autor: Caratti, Giorgio, Iqbal, Mudassar, Hunter, Louise, Kim, Donghwan, Wang, Ping, Vonslow, Ryan M., Begley, Nicola, Tetley, Abigail J., Woodburn, Joanna L., Pariollaud, Marie, Maidstone, Robert, Donaldson, Ian J., Zhang, Zhenguang, Ince, Louise M., Kitchen, Gareth, Baxter, Matthew, Poolman, Toryn M., Daniels, Dion A., Stirling, David R., Brocker, Chad, Gonzalez, Frank, Loudon, Andrew S.I., Bechtold, David A., Rattray, Magnus, Matthews, Laura C., Ray, David W.

Publikováno v: The Journal of Clinical Investigation
Caratti, G, Iqbal, M, Hunter, L, Kim, D, Wang, P, Vonslow, R M, Begley, N, Tetley, A J, Woodburn, J L, Pariollaud, M, Maidstone, R, Donaldson, I J, Zhang, Z, Ince, L M, Kitchen, G, Baxter, M, Poolman, T M, Daniels, D A, Stirling, D R, Brocker, C, Gonzalez, F, Loudon, A S, Bechtold, D A, Rattray, M, Matthews, L C & Ray, D W 2018, ' REVERBa couples the circadian clock to hepatic glucocorticoid action ', The Journal of clinical investigation, vol. 128, no. 10, pp. 4454-4471 . https://doi.org/10.1172/JCI96138

The glucocorticoid receptor (GR) is a major drug target in inflammatory disease. However, chronic glucocorticoid (GC) treatment leads to disordered energy metabolism, including increased weight gain, adiposity, and hepatosteatosis - all programs modu

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http://europepmc.org/articles/PMC6160001