De novo design of tyrosine and serine kinase-driven protein switches.

Autor: Woodall NB; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Weinberg Z; Department of Biochemistry & Biophysics, University of California San Francisco, San Francisco, CA, USA., Park J; Department of Biochemistry & Biophysics, University of California San Francisco, San Francisco, CA, USA., Busch F; Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH, USA.; Resource for Native Mass Spectrometry Guided Structural Biology, The Ohio State University, Columbus, OH, USA., Johnson RS; Department of Genome Sciences, University of Washington, Seattle, WA, USA., Feldbauer MJ; Institute for Protein Design, University of Washington, Seattle, WA, USA., Murphy M; Institute for Protein Design, University of Washington, Seattle, WA, USA., Ahlrichs M; Institute for Protein Design, University of Washington, Seattle, WA, USA., Yousif I; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Department of Bioengineering, University of Washington, Seattle, WA, USA., MacCoss MJ; Department of Genome Sciences, University of Washington, Seattle, WA, USA., Wysocki VH; Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH, USA.; Resource for Native Mass Spectrometry Guided Structural Biology, The Ohio State University, Columbus, OH, USA., El-Samad H; Department of Biochemistry & Biophysics, University of California San Francisco, San Francisco, CA, USA., Baker D; Department of Biochemistry, University of Washington, Seattle, WA, USA. dabaker@uw.edu.; Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA. dabaker@uw.edu.; Institute for Protein Design, University of Washington, Seattle, WA, USA. dabaker@uw.edu.

Publikováno v: Nature structural & molecular biology [Nat Struct Mol Biol] 2021 Sep; Vol. 28 (9), pp. 762-770. Date of Electronic Publication: 2021 Sep 13.

Self-assembly-based posttranslational protein oscillators.

Autor: Kimchi O; Harvard University School of Engineering and Applied Sciences, Cambridge, MA 02138, USA. okimchi@g.harvard.edu., Goodrich CP; Harvard University School of Engineering and Applied Sciences, Cambridge, MA 02138, USA., Courbet A; Department of Biochemistry, University of Washington, Seattle, WA 98105, USA.; Institute for Protein Design, University of Washington, Seattle, WA 98105, USA.; Howard Hughes Medical Institute, University of Washington, Seattle, WA 98105, USA., Curatolo AI; Harvard University School of Engineering and Applied Sciences, Cambridge, MA 02138, USA., Woodall NB; Department of Biochemistry, University of Washington, Seattle, WA 98105, USA.; Institute for Protein Design, University of Washington, Seattle, WA 98105, USA.; Howard Hughes Medical Institute, University of Washington, Seattle, WA 98105, USA., Baker D; Department of Biochemistry, University of Washington, Seattle, WA 98105, USA.; Institute for Protein Design, University of Washington, Seattle, WA 98105, USA.; Howard Hughes Medical Institute, University of Washington, Seattle, WA 98105, USA., Brenner MP; Harvard University School of Engineering and Applied Sciences, Cambridge, MA 02138, USA.; Kavli Institute for Bionano Science and Technology Harvard University, Cambridge, MA 02138, USA.

Publikováno v: Science advances [Sci Adv] 2020 Dec 16; Vol. 6 (51). Date of Electronic Publication: 2020 Dec 16 (Print Publication: 2020).

A cell-free platform for the prenylation of natural products and application to cannabinoid production.

Autor: Valliere MA; Department of Chemistry and Biochemistry, Molecular Biology Institute, UCLA-DOE Institute, University of California, Los Angeles, 90095, CA, USA., Korman TP; Department of Chemistry and Biochemistry, Molecular Biology Institute, UCLA-DOE Institute, University of California, Los Angeles, 90095, CA, USA., Woodall NB; Department of Biochemistry, Institute for Protein Design, University of Washington, Seattle, 98105, WA, USA., Khitrov GA; Department of Chemistry and Biochemistry, Molecular Biology Institute, UCLA-DOE Institute, University of California, Los Angeles, 90095, CA, USA., Taylor RE; Department of Chemistry and Biochemistry, Molecular Biology Institute, UCLA-DOE Institute, University of California, Los Angeles, 90095, CA, USA., Baker D; Department of Biochemistry, Institute for Protein Design, University of Washington, Seattle, 98105, WA, USA., Bowie JU; Department of Chemistry and Biochemistry, Molecular Biology Institute, UCLA-DOE Institute, University of California, Los Angeles, 90095, CA, USA. bowie@mbi.ucla.edu.

Publikováno v: Nature communications [Nat Commun] 2019 Feb 04; Vol. 10 (1), pp. 565. Date of Electronic Publication: 2019 Feb 04.

Combining machine learning with structure-based protein design to predict and engineer post-translational modifications of proteins.

Autor: Ertelt, Moritz^1,2 (AUTHOR), Mulligan, Vikram Khipple³ (AUTHOR), Maguire, Jack B.⁴ (AUTHOR), Lyskov, Sergey⁵ (AUTHOR), Moretti, Rocco^6,7 (AUTHOR), Schiffner, Torben¹ (AUTHOR), Meiler, Jens^1,2,6,7 (AUTHOR), Schoeder, Clara T.^1,2 (AUTHOR) clara.schoeder@medizin.uni-leipzig.de

Publikováno v: PLoS Computational Biology. 3/14/2024, Vol. 20 Issue 3, p1-20. 20p.

Secretion of endoplasmic reticulum protein VAPB/ALS8 requires topological inversion.

Autor: Kamemura, Kosuke, Kozono, Rio, Tando, Mizuki, Okumura, Misako, Koga, Daisuke, Kusumi, Satoshi, Tamai, Kanako, Okumura, Aoi, Sekine, Sayaka, Kamiyama, Daichi, Chihara, Takahiro

Publikováno v: Nature Communications; 10/10/2024, Vol. 15 Issue 1, p1-16, 16p