Zobrazeno 1 - 10
of 152
pro vyhledávání: '"Wood Mja."'
Autor:
Forouhan, M, Lim, WF, Zanetti-Domingues, LC, Tynan, CJ, Roberts, TC, Malik, B, Manzano, R, Speciale, AA, Ellerington, R, Garcia-Guerra, A, Fratta, P, Sorarú, G, Greensmith, L, Pennuto, M, Wood, MJA, Rinaldi, C
Publikováno v:
Acta Neuropathologica. 143:713-731
Androgens and androgen-related molecules exert a plethora of functions across different tissues, mainly through binding to the transcription factor androgen receptor (AR). Despite widespread therapeutic use and misuse of androgens as potent anabolic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e6b384ca8dc1f9f22794b9c798001f3
https://doi.org/10.1007/s00401-022-02428-1
https://doi.org/10.1007/s00401-022-02428-1
Publikováno v:
RSC Chemical Biology. 3:765-772
Oligonucleotides are rapidly emerging as powerful therapeutics for hard to treat diseases. Short single-stranded oligonucleotides can base pair with target RNA and alter gene expression, providing an attractive therapeutic approach at the genetic lev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::816b15556eb0a0b33dec6318baf8e24e
https://doi.org/10.1039/d2cb00100d
https://doi.org/10.1039/d2cb00100d
Publikováno v:
Nature Reviews. Drug Discovery
Other repository
Other repository
Oligonucleotides can be used to modulate gene expression via a range of processes including RNAi, target degradation by RNase H-mediated cleavage, splicing modulation, non-coding RNA inhibition, gene activation and programmed gene editing. As such, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ee170aa19d6147e52a2dd2a8968538e
https://doi.org/10.1038/s41573-020-0075-7
https://doi.org/10.1038/s41573-020-0075-7
Autor:
Baker, YR, Thorpe, C, Chen, J, Poller, LM, Cox, L, Kumar, P, Lim, WF, Lie, L, McClorey, G, Epple, S, Singleton, D, McDonough, MA, Hardwick, JS, Christensen, KE, Wood, MJA, Hall, JP, El-Sagheer, AH, Brown, T
Publikováno v:
Nature Communications 13(1), 4036 (2022). doi:10.1038/s41467-022-31636-2
Nature Communications 13(1), 4036 (2022). doi:10.1038/s41467-022-31636-2
Oligonucleotides that target mRNA have great promise as therapeutic agents for life-threatening conditions but suffer from poor bioavailability, hence high cost. As current
Oligonucleotides that target mRNA have great promise as therapeutic agents for life-threatening conditions but suffer from poor bioavailability, hence high cost. As current
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::675618c3e7f9d6cac2f949f550d87612
Autor:
Raquel Manzano, Yoshitsugu Aoki, Wood Mja., C. Sathyaprakash, Kevin Talbot, Miguel A. Varela, Y Hashimoto
Publikováno v:
Methods in Molecular Biology ISBN: 9781071607701
Several neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), have a complex genetic background, in addition to cases where the disease appears to manifest sporadically. The recent discovery of the hexanucleotide repeat expansion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c28a4812342f9dda9e3c3ca48ffd8d0f
https://pubmed.ncbi.nlm.nih.gov/32865792
https://pubmed.ncbi.nlm.nih.gov/32865792
Autor:
Wood Mja., Carlo Rinaldi
Publikováno v:
Nature Reviews Neurology. 14:9-21
Antisense oligonucleotides (ASOs) were first discovered to influence RNA processing and modulate protein expression over two decades ago; however, progress translating these agents into the clinic has been hampered by inadequate target engagement, in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d83e577f21dbc2ff4be31b8d45bacac5
https://doi.org/10.1038/nrneurol.2017.148
https://doi.org/10.1038/nrneurol.2017.148
Publikováno v:
Nucleic Acid Therapeutics
Splice-switching antisense oligonucleotides are emerging treatments for neuromuscular diseases, with several splice-switching oligonucleotides (SSOs) currently undergoing clinical trials such as for Duchenne muscular dystrophy (DMD) and spinal muscul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::171c00dc7231b77c59142b52b881d4b1
https://doi.org/10.1089/nat.2016.0652
https://doi.org/10.1089/nat.2016.0652
Autor:
Kevin Talbot, Wood Mja.
Effective treatment of spinal muscular atrophy with antisense oligonucleotide therapy opens the door to treating other neurological disorders with this approach.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8c202cf9929b6caba3b1308dc0c1c35
https://doi.org/10.1126/scitranslmed.aay2069
https://doi.org/10.1126/scitranslmed.aay2069
Publikováno v:
Methods in Molecular Biology ISBN: 9781493996698
Antisense oligonucleotides (ASOs) are a widely used form of gene therapy, which is translatable to multiple disorders. A major obstacle for ASO efficacy is its bioavailability for in vivo and in vitro studies. To overcome this challenge we use cell-p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64ddf8d15558098573ca132f7823bf00
https://pubmed.ncbi.nlm.nih.gov/31410800
https://pubmed.ncbi.nlm.nih.gov/31410800
Autor:
Coenen-Stass, AML, Sork, H, Gatto, S, Godfrey, C, Bhomra, A, Krjutškov, K, Hart, JR, Westholm, JO, O'Donovan, L, Roos, A, Lochmüller, H, Puri, PL, El Andaloussi, S, Wood, MJA, Roberts, TC
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 13, Iss, Pp 1-15 (2018)
Extracellular small RNAs (sRNAs), including microRNAs (miRNAs), are promising biomarkers for diseases such as Duchenne muscular dystrophy (DMD), although their biological relevance is largely unknown. To investigate the relationship between intracell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::82b14c40eac559c9cadec2b87c9b0f75
https://ora.ox.ac.uk/objects/uuid:5157ce00-a4dc-4099-90d3-8d71d84390f8
https://ora.ox.ac.uk/objects/uuid:5157ce00-a4dc-4099-90d3-8d71d84390f8