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Akademický článek

Predictive biomarkers for 5-fluorouracil and oxaliplatin-based chemotherapy in gastric cancers via profiling of patient-derived xenografts

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)

Gastric cancer is commonly treated by chemotherapy using 5-fluorouracil derivatives and platinum combination, but predictive biomarker remains lacking. Here, the authors develop a 30-gene prediction model to determine the responsiveness to 5-fluorour

Externí odkaz: https://doaj.org/article/08fe478b004a4631b3a74073129531e8

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Akademický článek

Gold thread implantation promotes hair growth in human and mice

Autor: Jong-Hwan Kim, Eun-Young Cho, Euna Kwon, Woo-Ho Kim, Jin-Sung Park, Yong-Soon Lee, Jun-Won Yun, Byeong-Cheol Kang

Publikováno v: Laboratory Animal Research, Vol 33, Iss 4, Pp 291-297 (2018)

Abstract Thread-embedding therapy has been widely applied for cosmetic purposes such as wrinkle reduction and skin tightening. Particularly, gold thread was reported to support connective tissue regeneration, but, its role in hair biology remains lar

Externí odkaz: https://doaj.org/article/562066fd5f234850bd0e8648b9521a1f

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Akademický článek

Helicobacter pylori Eradication Can Reverse the Methylation-Associated Regulation of miR-200a/b in Gastric Carcinogenesis

Autor: Ji Min Choi, Sang Gyun Kim, Hyo-Joon Yang, Joo Hyun Lim, Nam-Yun Cho, Woo Ho Kim, Joo Sung Kim, Hyun Chae Jung

Publikováno v: Gut and Liver, Vol 14, Iss 5, Pp 571-580 (2020)

Background/Aims: Epigenetic change is one of the mechanisms that regulates the expression of microRNAs (miRNAs) and is known to play a role in Helicobacter pylori-associated gastric carcinogenesis. We aimed to evaluate the epigenetic changes of miR-2

Externí odkaz: https://doaj.org/article/24b498cabea845409df69b8f1bcc6914

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Akademický článek

Clinical Implication and Risk Factors for Malignancy of Atypical Gastric Gland during Forceps Biopsy

Autor: Min Seong Kim, Sang Gyun Kim, Hyunsoo Chung, Jung Kim, Hyoungju Hong, Hee Jong Lee, Hyun Ju Kim, Min A Kim, Woo Ho Kim, Hyun Chae Jung

Publikováno v: Gut and Liver, Vol 12, Iss 5, Pp 523-529 (2018)

Background/AimsAlthough forceps biopsy is performed for suspicious gastric tumors during endoscopy, it is difficult to determine treatment strategies for atypical gastric glands due to uncertainty of the diagnosis. The aim of this study was to invest

Externí odkaz: https://doaj.org/article/adb1cc1a163e4b02bed403e54c6537f8

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Data from RAD51C-Deficient Cancer Cells Are Highly Sensitive to the PARP Inhibitor Olaparib

Autor: Yung-Jue Bang, Woo-Ho Kim, Mark J. O'Connor, Tae-You Kim, Do-Youn Oh, Sae-Won Han, Kyung-Hun Lee, Hwang-Phill Kim, Hyung-Seok Hur, Hyun-Jin Nam, Sang-Hyun Song, Young-Kwang Yoon, Seock-Ah Im, Ahrum Min

A PARP inhibitor is a rationally designed targeted therapy for cancers with impaired DNA repair abilities. RAD51C is a paralog of RAD51 that has an important role in the DNA damage response. We found that cell lines sensitive to a novel oral PARP inh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f9f5094a8854485e940ee1e3b940ad3
https://doi.org/10.1158/1535-7163.c.6536515.v1

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Supplementary Figures 1 - 9, Tables 1 - 2 from RAD51C-Deficient Cancer Cells Are Highly Sensitive to the PARP Inhibitor Olaparib

PDF file - 3250K, Figure S1 Olaparib has variable levels of anti-tumor activity in human cancer cell lines. Figure S2 Olaparib sensitive cell lines have different patterns of gene expression compared to insensitive cell lines. Figure S3 PTEN expressi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a819c139d685c956d0d349526c00c191
https://doi.org/10.1158/1535-7163.22500604.v1

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