Zobrazeno 1 - 10 of 26 pro vyhledávání: '"Woo Seung Son"'
1
Akademický článek
Synthesis and biological evaluation of pyrrolidine-based T-type calcium channel inhibitors for the treatment of neuropathic pain
Autor: Hak Kyun Yang, Woo Seung Son, Keon Seung Lim, Gun Hee Kim, Eun Jeong Lim, Changdev G. Gadhe, Jae Yeol Lee, Kyu-Sung Jeong, Sang Min Lim, Ae Nim Pae
Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 33, Iss 1, Pp 1460-1471 (2018)
The treatment of neuropathic pain is one of the urgent unmet medical needs and T-type calcium channels are promising therapeutic targets for neuropathic pain. Several potent T-type channel inhibitors showed promising in vivo efficacy in neuropathic p
Externí odkaz: https://doaj.org/article/a75094cd1879498e85b97dd69a6730cb
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2
Akademický článek
Estimating utility weights and quality-adjusted life year loss for colorectal cancer-related health states in Korea
Autor: Jin Yong Lee, Minsu Ock, Min-Woo Jo, Woo-Seung Son, Hyeon-Jeong Lee, Seon-Ha Kim, Hyun Joo Kim, Jong Lyul Lee
Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
Abstract We aimed to assess utility weight of health states associated with colorectal cancer (CRC) that reflect the societal preference of the Korean population and to estimate the quality-adjusted life year (QALY) loss with CRC. We recruited 607 in
Externí odkaz: https://doaj.org/article/906fb9cf798f4183a10a62aa9249176c
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3
Abstract 3323: Discovery of a small-molecule inhibitor that can target EGFR with C797S mutation
Autor: Dongsu Kim, Woo Seung Son, Anna Jang, Yeri Lee, Donggeon Kim, Changyu Choi, Kyung Hoon Min, Sung Pil Choi, Sang Kyun Lim
Publikováno v: Cancer Research. 82:3323-3323
EGFR is a transmembrane protein that functions as a receptor tyrosine kinase (RTK). Upon ligand binding or by activating mutations (Exon19 deletion, L858R mutation, and others), EGFR turns on the downstream signals that include oncogenic RAS/MEK/ERK,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::24c17718d12bb9d1df76bb40abcd6f20
https://doi.org/10.1158/1538-7445.am2022-3323
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4
Akademický článek
Congestion-Based Earthquake Emergency Evacuation Simulation Model for Underground Structure
Autor: Mintaek Yoo, Sunnie Haam, Woo Seung Song
Publikováno v: Buildings, Vol 14, Iss 10, p 3217 (2024)
Herein, the Dijkstra algorithm was used to develop a model that considers evacuee congestion and derives an optimal evacuation route in underground structures in the event of an earthquake. The ground conditions and seismic intensities were varied, a
Externí odkaz: https://doaj.org/article/4626656a5aac4352a9fd91bc28f8f8b8
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5
Health Related Quality of Life in Patients with Osteoporotic Vertebral Fracture
Autor: Je Hoon Jeong, Min-Woo Jo, Dong Kyu Chin, Woo-Seung Son, Minsu Ock, Jung-Kil Lee
Background. This study aims to examine the validity of European quality of life-5 dimensions, 3-level version (EQ-5D-3L) on patients with osteoporotic vertebral fractures and compare health related quality of life (QOL) of these patients with them of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6d8ca0f344177e437bd28ff279262a57
https://doi.org/10.21203/rs.3.rs-27640/v1
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6
Validation of the European Quality of Life-5 Dimensions, 3-Level Version (EQ-5D-3L) in Patients With Osteoporotic Vertebral Fracture and Comparing Their Health-Related Quality of Life With That of the General Population in Korea
Autor: Je Hoon Jeong, Min-Woo Jo, Dong Kyu Chin, Woo-Seung Son, Minsu Ock, Jung-Kil Lee
Publikováno v: Korean Journal of Neurotrauma. 18:64
This study examined the validity of the European Quality of Life-5 dimensions, 3-Level version (EQ-5D-3L) in patients with osteoporotic vertebral compression fractures (OVCF) and compared the health-related quality of life (HRQOL) of these patients w
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84e8391b1e53c7663ec07c71afe8368a
https://doi.org/10.13004/kjnt.2022.18.e19
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8
Structural hybridization of pyrrolidine-based T-type calcium channel inhibitors and exploration of their analgesic effects in a neuropathic pain model
Autor: Sang Min Lim, Kyu Sung Jeong, Woo Seung Son, Ae Nim Pae
Publikováno v: Bioorganicmedicinal chemistry letters. 29(10)
Highly effective and safe drugs for the treatment of neuropathic pain are urgently required and it was shown that blocking T-type calcium channels can be a promising strategy for drug development for neuropathic pain. We have developed pyrrolidine-ba
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c98f9b93558c231505529b8c16202c1b
https://pubmed.ncbi.nlm.nih.gov/30928197
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