PHD3 Loss Promotes Exercise Capacity and Fat Oxidation in Skeletal Muscle

Autor: Yoon, Haejin, Spinelli, Jessica B., Zaganjor, Elma, Wong, Samantha J., German, Natalie J., Randall, Elizabeth C., Dean, Afsah, Clermont, Allen, Paulo, Joao A., Garcia, Daniel, Li, Hao, Rombold, Olivia, Agar, Nathalie Y.R., Goodyear, Laurie J., Shaw, Reuben J., Gygi, Steven P., Auwerx, Johan, Haigis, Marcia C.

Publikováno v: In Cell Metabolism 4 August 2020 32(2):215-228

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Branched-chain α-ketoacids aerobically activate HIF1α signalling in vascular cells.

Autor: Xiao W; Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Department of Toxicology, School of Public Health, Peking University, Beijing, China.; Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety, School of Public Health, Peking University, Beijing, China.; Key Laboratory of State Administration of Traditional Chinese Medicine for Compatibility Toxicology, School of Public Health, Peking University, Beijing, China., Shrimali N; Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Vigder N; Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Oldham WM; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Clish CB; Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA., He H; Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Wong SJ; Department of Cell Biology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA., Wertheim BM; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Arons E; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Haigis MC; Department of Cell Biology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA., Leopold JA; Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Loscalzo J; Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. jloscalzo@rics.bwh.harvard.edu.

Publikováno v: Nature metabolism [Nat Metab] 2024 Oct 29. Date of Electronic Publication: 2024 Oct 29.