Histidine-Mediated Ion Specific Effects Enable Salt Tolerance of a Pore-Forming Marine Antimicrobial Peptide

Autor: Xian, Wujing, Hennefarth, Matthew R, Lee, Michelle W, Do, Tran, Lee, Ernest Y, Alexandrova, Anastassia N, Wong, Gerard CL

Publikováno v: Angewandte Chemie (International ed. in English), vol 61, iss 25

Antimicrobial peptides (AMPs) preferentially permeate prokaryotic membranes via electrostatic binding and membrane remodeling. Such action is drastically suppressed by high salt due to increased electrostatic screening, thus it is puzzling how marine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::eda4ba43151b3a78bf06f74facc4dfea
https://escholarship.org/uc/item/4tj6t5jd

Crystallinity of Double-Stranded RNA-Antimicrobial Peptide Complexes Modulates Toll-Like Receptor 3-Mediated Inflammation

Autor: Lee, Ernest Y, Takahashi, Toshiya, Curk, Tine, Dobnikar, Jure, Gallo, Richard L, Wong, Gerard CL

Publikováno v: ACS nano, vol 11, iss 12

Double-stranded RNA (dsRNA) induces production of pro-inflammatory cytokines in normal human epidermal keratinocytes (NHEK) by specific binding to endosomal Toll-like receptor-3 (TLR3). Recently, it has been shown that hyperactivation of TLR3 in psor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35d09e0241d4f20a16ebbb4dc45c70e5
https://www.repository.cam.ac.uk/handle/1810/270953

Increased LL37 in psoriasis and other inflammatory disorders promotes LDL uptake and atherosclerosis.

Autor: Nakamura Y; Department of Dermatology and., Kulkarni NN; Department of Dermatology and., Takahashi T; Department of Dermatology and., Alimohamadi H; Department of Bioengineering, UCLA, Los Angeles, California, USA., Dokoshi T; Department of Dermatology and., Liu E; Department of Dermatology and., Shia M; Department of Dermatology and., Numata T; Department of Dermatology and., Luo EW; Department of Bioengineering, UCLA, Los Angeles, California, USA., Gombart AF; Linus Pauling Institute, Department of Biochemistry and Biophysics, Oregon State University, Corvallis, Oregon, USA., Yang X; Division of Cardiovascular Diseases., Secrest P; Department of Medicine, Division of Endocrinology and Metabolism, and., Gordts PL; Department of Medicine, Division of Endocrinology and Metabolism, and.; Glycobiology Research and Training Center, UCSD, La Jolla, California, USA., Tsimikas S; Division of Cardiovascular Diseases., Wong GC; Department of Bioengineering, UCLA, Los Angeles, California, USA., Gallo RL; Department of Dermatology and.

Publikováno v: The Journal of clinical investigation [J Clin Invest] 2024 Mar 01; Vol. 134 (5). Date of Electronic Publication: 2024 Mar 01.

Heterogeneity in surface sensing suggests a division of labor in Pseudomonas aeruginosa populations.

Autor: Armbruster CR; Department of Microbiology, University of Washington, Seattle, United States., Lee CK; Department of Bioengineering, University of California, Los Angeles, Los Angeles, United States.; Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, United States.; California NanoSystems Institute, University of California, Los Angeles, Los Angeles, United States., Parker-Gilham J; Department of Microbiology, University of Washington, Seattle, United States., de Anda J; Department of Bioengineering, University of California, Los Angeles, Los Angeles, United States.; Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, United States.; California NanoSystems Institute, University of California, Los Angeles, Los Angeles, United States., Xia A; Hefei National Laboratory for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei, China., Zhao K; Key Laboratory of Systems Bioengineering (Ministry of Education), School of Chemical Engineering and Technology, Tianjin University, Tianjin, China.; Collaborative Innovation Centre of Chemical Science and Engineering, Tianjin University, Tianjin, China., Murakami K; Department of Oral Microbiology, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan., Tseng BS; School of Life Sciences, University of Nevada, Las Vegas, United States., Hoffman LR; Department of Microbiology, University of Washington, Seattle, United States.; Department of Pediatrics, University of Washington, Seattle, United States., Jin F; Hefei National Laboratory for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei, China.; Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China., Harwood CS; Department of Microbiology, University of Washington, Seattle, United States., Wong GC; Department of Bioengineering, University of California, Los Angeles, Los Angeles, United States.; Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, United States.; California NanoSystems Institute, University of California, Los Angeles, Los Angeles, United States., Parsek MR; Department of Microbiology, University of Washington, Seattle, United States.; Integrative Microbiology Research Centre, South China Agricultural University, Guangzhou, China.

Publikováno v: ELife [Elife] 2019 Jun 10; Vol. 8. Date of Electronic Publication: 2019 Jun 10.