Výsledky vyhledávání - "Wong, Gerard CL"

Akademický článek

Sensational biofilms: surface sensing in bacteria

Autor: O’Toole, George A, Wong, Gerard CL

Publikováno v: In Current Opinion in Microbiology April 2016 30:139-146

Histidine-Mediated Ion Specific Effects Enable Salt Tolerance of a Pore-Forming Marine Antimicrobial Peptide

Autor: Xian, Wujing, Hennefarth, Matthew R, Lee, Michelle W, Do, Tran, Lee, Ernest Y, Alexandrova, Anastassia N, Wong, Gerard CL

Publikováno v: Angewandte Chemie (International ed. in English), vol 61, iss 25

Antimicrobial peptides (AMPs) preferentially permeate prokaryotic membranes via electrostatic binding and membrane remodeling. Such action is drastically suppressed by high salt due to increased electrostatic screening, thus it is puzzling how marine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::eda4ba43151b3a78bf06f74facc4dfea
https://escholarship.org/uc/item/4tj6t5jd

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Clostridioides difficile Toxin A Remodels Membranes and Mediates DNA Entry Into Cells to Activate Toll-Like Receptor 9 Signaling

Autor: Chen, Xinhua, Yang, Xiaotong, de Anda, Jaime, Huang, Jun, Li, Dan, Xu, Hua, Shields, Kelsey S, Džunková, Mária, Hansen, Joshua, Patel, Ishan J, Yee, Eric U, Golenbock, Douglas T, Grant, Marianne A, Wong, Gerard CL, Kelly, Ciarán P

Publikováno v: Gastroenterology, vol 159, iss 6

Background & aimsClostridioides difficile toxin A (TcdA) activates the innate immune response. TcdA co-purifies with DNA. Toll-like receptor 9 (TLR9) recognizes bacterial DNA to initiate inflammation. We investigated whether DNA bound to TcdA activat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::1e1b2a7ae3f85933a3b3621858c1c316
https://escholarship.org/uc/item/6498h5zq

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Crystallinity of Double-Stranded RNA-Antimicrobial Peptide Complexes Modulates Toll-Like Receptor 3-Mediated Inflammation

Autor: Lee, Ernest Y, Takahashi, Toshiya, Curk, Tine, Dobnikar, Jure, Gallo, Richard L, Wong, Gerard CL

Publikováno v: ACS nano, vol 11, iss 12

Double-stranded RNA (dsRNA) induces production of pro-inflammatory cytokines in normal human epidermal keratinocytes (NHEK) by specific binding to endosomal Toll-like receptor-3 (TLR3). Recently, it has been shown that hyperactivation of TLR3 in psor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35d09e0241d4f20a16ebbb4dc45c70e5
https://www.repository.cam.ac.uk/handle/1810/270953

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Direct Antimicrobial Activity of IFN-β

Autor: Kaplan, Amber, Lee, Michelle W, Wolf, Andrea J, Limon, Jose J, Becker, Courtney A, Ding, Minna, Murali, Ramachandran, Lee, Ernest Y, Liu, George Y, Wong, Gerard CL, Underhill, David M

Publikováno v: Journal of immunology (Baltimore, Md. : 1950), vol 198, iss 10

Type I IFNs are a cytokine family essential for antiviral defense. More recently, type I IFNs were shown to be important during bacterial infections. In this article, we show that, in addition to known cytokine functions, IFN-β is antimicrobial. Par

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::e38b995a8177ca124bb6990590025653
https://escholarship.org/uc/item/12k5p3gh

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