Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Wonderful T. Choga"'
Autor:
Wonderful T. Choga, Gobuiwang Khilly Kurusa (Gasenna), James Emmanuel San, Tidimalo Ookame, Irene Gobe, Mohammed Chand, Badisa Phafane, Kedumetse Seru, Patience Matshosi, Boitumelo Zuze, Nokuthula Ndlovu, Teko Matsuru, Dorcas Maruapula, Ontlametse T. Bareng, Kutlo Macheke, Lesego Kuate-Lere, Labapotswe Tlale, Onalethata Lesetedi, Modiri Tau, Mpaphi B. Mbulawa, Pamela Smith-Lawrence, Mogomotsi Matshaba, Roger Shapiro, Joseph Makhema, Darren P. Martin, Tulio de Oliveira, Richard J. Lessells, Shahin Lockman, Simani Gaseitsiwe, Sikhulile Moyo
Publikováno v:
International Journal of Infectious Diseases, Vol 138, Iss , Pp 91-96 (2024)
We investigated intra-host genetic evolution using two SARS-CoV-2 isolates from a fully vaccinated (primary schedule x2 doses of AstraZeneca plus a booster of Pfizer), >70-year-old woman with a history of lymphoma and hypertension who presented a SAR
Externí odkaz:
https://doaj.org/article/a4563b67ede2463ca061c016f76e974e
Autor:
Motswedi Anderson, Bonolo B. Phinius, Basetsana K. Phakedi, Mbatshi Mudanga, Lynnette N. Bhebhe, Girlie N. Tlhabano, Patience Motshosi, Tsholofelo Ratsoma, Kabo Baruti, Gorata Mpebe, Wonderful T. Choga, Richard Marlink, Dieter Glebe, Jason T. Blackard, Sikhulile Moyo, Anna Kramvis, Simani Gaseitsiwe
Publikováno v:
Frontiers in Microbiology, Vol 15 (2024)
AimThis study aimed to determine the kinetics of occult hepatitis B virus infections (OBI) among people with HIV (PWH).MethodsThe study used archived plasma samples from longitudinal HIV natural history studies. We identified new OBI cases and assess
Externí odkaz:
https://doaj.org/article/a1fb6e1bfe774ca3bcb77efb42001557
Autor:
Natasha O. Moraka, Wonderful T. Choga, Marea N. Pema, Moses Kudzai Chawawa, Irene Gobe, Margaret Mokomane, Ontlametse T. Bareng, Lynette Bhebhe, Nametso Kelentse, Graceful Mulenga, Molly Pretorius Holme, Terence Mohammed, Catherine K. Koofhethile, Joseph M. Makhema, Roger Shapiro, Shahin Lockman, Sikhulile Moyo, Simani Gaseitsiwe
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract We used HIV-1C sequences to predict (in silico) resistance to 33 known broadly neutralizing antibodies (bnAbs) and evaluate the different HIV-1 Env characteristics that may affect virus neutralization. We analyzed proviral sequences from adu
Externí odkaz:
https://doaj.org/article/34cd02c202c244d98df4161bb39f3c8a
Autor:
Bonolo B. Phinius, Wonderful T. Choga, Motswedi Anderson, Margaret Mokomane, Irene Gobe, Tsholofelo Ratsoma, Basetsana Phakedi, Gorata Mpebe, Lynnette Bhebhe, Tendani Gaolathe, Mosepele Mosepele, Joseph Makhema, Roger Shapiro, Shahin Lockman, Rosemary Musonda, Sikhulile Moyo, Simani Gaseitsiwe
Publikováno v:
Biomedicines, Vol 12, Iss 7, p 1561 (2024)
(1) Background: Hepatitis B virus (HBV) sequencing data are important for monitoring HBV evolution. We aimed to molecularly characterize HBV sequences from participants with HBV surface antigen-positive (HBsAg+) serology and occult hepatitis B infect
Externí odkaz:
https://doaj.org/article/6829cfe2e45447ae99c2e3fcd79459a4
Autor:
Motswedi Anderson, Thabo Mangogola, Bonolo B. Phinius, Gorata Mpebe, Christopher O. Aimakhu, Wonderful T. Choga, Basetsana Phakedi, Lynnette N. Bhebhe, Doreen Ditshwanelo, Kabo Baruti, Linda Mpofu-Dobo, Lebogang Othusitse, Tsholofelo Ratsoma, Tendani Gaolathe, Joseph Makhema, Roger Shapiro, Shahin Lockman, Sikhulile Moyo, Simani Gaseitsiwe
Publikováno v:
Microorganisms, Vol 12, Iss 6, p 1207 (2024)
(1) Background: we determined the prevalence of the hepatitis B virus (HBV) amongst people without human immunodeficiency virus (HIV) in rural and peri-urban areas in Botswana. (2) Methods: We screened for the hepatitis B surface antigen (HBsAg) from
Externí odkaz:
https://doaj.org/article/ea3db4e9939c447982af0187a751846f
Autor:
Patrick T. Mokgethi, Wonderful T. Choga, Dorcas Maruapula, Natasha O. Moraka, Kaelo K. Seatla, Ontlametse T. Bareng, Doreen D. Ditshwanelo, Graceful Mulenga, Terence Mohammed, Pearl M. Kaumba, Moses Chihungwa, Tafireyi Marukutira, Sikhulile Moyo, Catherine K. Koofhethile, Diana Dickinson, Sununguko W. Mpoloka, Simani Gaseitsiwe
Publikováno v:
Frontiers in Microbiology, Vol 15 (2024)
BackgroundApproximately 30,000 non-citizens are living with HIV in Botswana, all of whom as of 2020 are eligible to receive free antiretroviral treatment (ART) within the country. We assessed the prevalence of HIV-1 mutational profiles [pre-treatment
Externí odkaz:
https://doaj.org/article/9074ed2378d34979a3500ea0e7911585
Autor:
Prisca K. Thami, Wonderful T. Choga, Collet Dandara, Stephen J. O’Brien, Myron Essex, Simani Gaseitsiwe, Emile R. Chimusa
Publikováno v:
Frontiers in Genetics, Vol 14 (2023)
HIV infection continues to be a major global public health issue. The population heterogeneity in susceptibility or resistance to HIV-1 and progression upon infection is attributable to, among other factors, host genetic variation. Therefore, identif
Externí odkaz:
https://doaj.org/article/81eba73213784e279e6a6832680e1247
Autor:
Boitumelo J. L. Zuze, Botshelo T. Radibe, Wonderful T. Choga, Ontlametse T. Bareng, Natasha O. Moraka, Dorcas Maruapula, Kedumetse Seru, Patrick Mokgethi, Baitshepi Mokaleng, Nokuthula Ndlovu, Nametso Kelentse, Molly Pretorius-Holme, Roger Shapiro, Shahin Lockman, Joseph Makhema, Vlad Novitsky, Kaelo K. Seatla, Sikhulile Moyo, Simani Gaseitsiwe
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 6 (2023)
ABSTRACT There are limited data on the prevalence of fostemsavir (FTR) resistance-associated polymorphisms in people with HIV in Botswana. We sought to determine the prevalence of FTR resistance-associated polymorphisms in HIV-1 subtype C sequences f
Externí odkaz:
https://doaj.org/article/8a3484c8f0984aef98f28951e867c1e8
Autor:
Wonderful T. Choga, Samantha L. Letsholo, Chandapiwa Marobela‐Raborokgwe, Irene Gobe, Mbatshi Mazwiduma, Dorcas Maruapula, John Rukwava, Mary Gorettie Binta, Boitumelo J. L Zuze, Legodile Koopile, Kedumetse Seru, Patience Motshosi, Ontlametse Thato Bareng, Botshelo Radibe, Pamela Smith‐Lawrence, Kutlo Macheke, Lesego Kuate‐Lere, Modisa S. Motswaledi, Mpaphi B. Mbulawa, Mogomotsi Matshaba, Kereng V. Masupu, Shahin Lockman, Roger Shapiro, Joseph Makhema, Mosepele Mosepele, Simani Gaseitsiwe, Sikhulile Moyo
Publikováno v:
Veterinary Medicine and Science, Vol 9, Iss 4, Pp 1465-1472 (2023)
Abstract We sought to investigate whether SARS‐CoV‐2 was present, and to perform full‐length genomic sequencing, in a 5‐year‐old male crossbreed dog from Gaborone, Botswana that presented overt clinical signs (flu‐like symptoms, dry hacki
Externí odkaz:
https://doaj.org/article/92e2601e0fa74b2cb40aab8c50df3dee
Autor:
Ontlametse T. Bareng, Sikhulile Moyo, Mbatshi Mudanga, Kagiso Sebina, Catherine K. Koofhethile, Wonderful T. Choga, Natasha O. Moraka, Dorcas Maruapula, Irene Gobe, Modisa S. Motswaledi, Rosemary Musonda, Bornapate Nkomo, Dinah Ramaabya, Tony Chebani, Penny Makuruetsa, Joseph Makhema, Roger Shapiro, Shahin Lockman, Simani Gaseitsiwe
Publikováno v:
Viruses, Vol 16, Iss 5, p 720 (2024)
We evaluated subsequent virologic outcomes in individuals experiencing low-level virem ia (LLV) on dolutegravir (DTG)-based first-line antiretroviral therapy (ART) in Botswana. We used a national dataset from 50,742 adults who initiated on DTG-based
Externí odkaz:
https://doaj.org/article/9a9fbac7f29e4b949b9064b7914cbad8